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• W4377565280 abstract "Osteoporosis is an age-related disease of bone metabolism marked by reduced bone mineral density and impaired bone strength. The disease causes the bones to weaken and break more easily. Osteoclasts participate in bone resorption more than osteoblasts participate in bone formation, disrupting bone homeostasis and leading to osteoporosis. Currently, drug therapy for osteoporosis includes calcium supplements, vitamin D, parathyroid hormone, estrogen, calcitonin, bisphosphates, and other medications. These medications are effective in treating osteoporosis but have side effects. Copper is a necessary trace element in the human body, and studies have shown that it links to the development of osteoporosis. Cuproptosis is a recently proposed new type of cell death. Copper-induced cell death regulates by lipoylated components mediated via mitochondrial ferredoxin 1; that is, copper binds directly to the lipoylated components of the tricarboxylic acid cycle, resulting in lipoylated protein accumulation and subsequent loss of iron-sulfur cluster proteins, leading to proteotoxic stress and eventually cell death. Therapeutic options for tumor disorders include targeting the intracellular toxicity of copper and cuproptosis. The hypoxic environment in bone and the metabolic pathway of glycolysis to provide energy in cells can inhibit cuproptosis, which may promote the survival and proliferation of various cells, including osteoblasts, osteoclasts, effector T cells, and macrophages, thereby mediating the osteoporosis process. As a result, our group tried to explain the relationship between the role of cuproptosis and its essential regulatory genes, as well as the pathological mechanism of osteoporosis and its effects on various cells. This study intends to investigate a new treatment approach for the clinical treatment of osteoporosis that is beneficial to the treatment of osteoporosis." @default.
• W4377565280 created "2023-05-24" @default.
• W4377565280 creator A5031191384 @default.
• W4377565280 creator A5042879481 @default.
• W4377565280 creator A5063902702 @default.
• W4377565280 creator A5086844687 @default.
• W4377565280 creator A5088664989 @default.
• W4377565280 date "2023-05-05" @default.
• W4377565280 modified "2023-10-14" @default.
• W4377565280 title "Cuproptosis-a potential target for the treatment of osteoporosis" @default.
• W4377565280 cites W1448587601 @default.
• W4377565280 cites W1489196249 @default.
• W4377565280 cites W1513928844 @default.
• W4377565280 cites W1545889271 @default.
• W4377565280 cites W1547203551 @default.
• W4377565280 cites W1628207109 @default.
• W4377565280 cites W1954174419 @default.
• W4377565280 cites W1965696818 @default.
• W4377565280 cites W1969299453 @default.
• W4377565280 cites W1975141692 @default.
• W4377565280 cites W1987532001 @default.
• W4377565280 cites W1987704635 @default.
• W4377565280 cites W1987854862 @default.
• W4377565280 cites W1990884245 @default.
• W4377565280 cites W2008710602 @default.
• W4377565280 cites W2008847140 @default.
• W4377565280 cites W2008932730 @default.
• W4377565280 cites W2014232255 @default.
• W4377565280 cites W2022941427 @default.
• W4377565280 cites W2027169265 @default.
• W4377565280 cites W2029066952 @default.
• W4377565280 cites W2035036667 @default.
• W4377565280 cites W2035189089 @default.
• W4377565280 cites W2044515633 @default.
• W4377565280 cites W2052257773 @default.
• W4377565280 cites W2054738820 @default.
• W4377565280 cites W2056925595 @default.
• W4377565280 cites W2060790071 @default.
• W4377565280 cites W2063931700 @default.
• W4377565280 cites W2064850280 @default.
• W4377565280 cites W2066217988 @default.
• W4377565280 cites W2072451938 @default.
• W4377565280 cites W2073429636 @default.
• W4377565280 cites W2074172355 @default.
• W4377565280 cites W2076272449 @default.
• W4377565280 cites W2081078755 @default.
• W4377565280 cites W2081091921 @default.
• W4377565280 cites W2084939005 @default.
• W4377565280 cites W2087526300 @default.
• W4377565280 cites W2088417711 @default.
• W4377565280 cites W2091343209 @default.
• W4377565280 cites W2092309785 @default.
• W4377565280 cites W2093221448 @default.
• W4377565280 cites W2093252878 @default.
• W4377565280 cites W2096459042 @default.
• W4377565280 cites W2108887402 @default.
• W4377565280 cites W2110498771 @default.
• W4377565280 cites W2111419241 @default.
• W4377565280 cites W2113500948 @default.
• W4377565280 cites W2118296350 @default.
• W4377565280 cites W2120339601 @default.
• W4377565280 cites W2121671314 @default.
• W4377565280 cites W2125847914 @default.
• W4377565280 cites W2126525177 @default.
• W4377565280 cites W2127845947 @default.
• W4377565280 cites W2130781987 @default.
• W4377565280 cites W2132628525 @default.
• W4377565280 cites W2134107900 @default.
• W4377565280 cites W2140380746 @default.
• W4377565280 cites W2141119980 @default.
• W4377565280 cites W2148855636 @default.
• W4377565280 cites W2153101639 @default.
• W4377565280 cites W2154920222 @default.
• W4377565280 cites W2156813826 @default.
• W4377565280 cites W2157478170 @default.
• W4377565280 cites W2157874555 @default.
• W4377565280 cites W2159294156 @default.
• W4377565280 cites W2160287478 @default.
• W4377565280 cites W2161475223 @default.
• W4377565280 cites W2162295781 @default.
• W4377565280 cites W2202256884 @default.
• W4377565280 cites W2238549838 @default.
• W4377565280 cites W2247851187 @default.
• W4377565280 cites W2257572677 @default.
• W4377565280 cites W2271948826 @default.
• W4377565280 cites W2326274978 @default.
• W4377565280 cites W2346403854 @default.
• W4377565280 cites W2407494057 @default.
• W4377565280 cites W2422997261 @default.
• W4377565280 cites W2440269545 @default.
• W4377565280 cites W2465255264 @default.
• W4377565280 cites W2467271588 @default.
• W4377565280 cites W2496179075 @default.
• W4377565280 cites W2510770156 @default.
• W4377565280 cites W2519544249 @default.
• W4377565280 cites W2521129618 @default.
• W4377565280 cites W2546328780 @default.
• W4377565280 cites W2564310546 @default.
• W4377565280 cites W2587043662 @default.
• W4377565280 cites W2589706572 @default.

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