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- W4377609197 abstract "The chapter discusses the fluorinated pyrimidines. The fluorinated pyrimidines have been used as chemotherapeutic agents and as tools to dissect the biological and biochemical processes. This chapter examines both of these aspects. Thus, in comparing the fluorouracil and the trifluorothymine series, it is found that they both inhibit thymidylate synthetase, but by different mechanisms. Moreover, the former series is incorporated into the RNA and the latter series is incorporated into the deoxyribonucleic acid (DNA). Each series, then, is involved in two different biochemical mechanisms that make the compounds versatile metabolic tools, but without the apparently unique specificity of the actinomycins. The chapter discusses the clinical efficacy of fluorinated pyrimidines in cancer chemotherapy. The chapter also discusses various biological effects, such as: (a) inhibition of thymidylate synthetase, (b) mechanisms of cellular resistance, and (c) effects on bacterial cell walls. It also discusses the other biological effects, such as: (a) teratogenesis and morphogenesis, (b) insect chemisterilization, and (c) effects on chromosomes." @default.
- W4377609197 created "2023-05-24" @default.
- W4377609197 creator A5077120756 @default.
- W4377609197 date "1965-01-01" @default.
- W4377609197 modified "2023-10-14" @default.
- W4377609197 title "Fluorinated Pyrimidines" @default.
- W4377609197 cites W107818860 @default.
- W4377609197 cites W109577459 @default.
- W4377609197 cites W1503377185 @default.
- W4377609197 cites W1518006117 @default.
- W4377609197 cites W1521617327 @default.
- W4377609197 cites W1531520353 @default.
- W4377609197 cites W1579280493 @default.
- W4377609197 cites W1588588829 @default.
- W4377609197 cites W1600658048 @default.
- W4377609197 cites W161844124 @default.
- W4377609197 cites W16336426 @default.
- W4377609197 cites W166402193 @default.
- W4377609197 cites W167276989 @default.
- W4377609197 cites W170829294 @default.
- W4377609197 cites W17931924 @default.
- W4377609197 cites W1843534975 @default.
- W4377609197 cites W1872345435 @default.
- W4377609197 cites W1963834641 @default.
- W4377609197 cites W1964700067 @default.
- W4377609197 cites W1965507185 @default.
- W4377609197 cites W1967271448 @default.
- W4377609197 cites W1968559101 @default.
- W4377609197 cites W1969180972 @default.
- W4377609197 cites W1970174166 @default.
- W4377609197 cites W1975508635 @default.
- W4377609197 cites W1976374039 @default.
- W4377609197 cites W1976957672 @default.
- W4377609197 cites W1977560762 @default.
- W4377609197 cites W1978890409 @default.
- W4377609197 cites W1980253503 @default.
- W4377609197 cites W1980582851 @default.
- W4377609197 cites W1980981525 @default.
- W4377609197 cites W1981753177 @default.
- W4377609197 cites W1982193960 @default.
- W4377609197 cites W1982290501 @default.
- W4377609197 cites W1982490763 @default.
- W4377609197 cites W1983068437 @default.
- W4377609197 cites W1983407779 @default.
- W4377609197 cites W1984011011 @default.
- W4377609197 cites W1986733649 @default.
- W4377609197 cites W1987454511 @default.
- W4377609197 cites W1989324737 @default.
- W4377609197 cites W1990619701 @default.
- W4377609197 cites W1994748243 @default.
- W4377609197 cites W1996479050 @default.
- W4377609197 cites W2001695634 @default.
- W4377609197 cites W2001985059 @default.
- W4377609197 cites W2003503815 @default.
- W4377609197 cites W2004793118 @default.
- W4377609197 cites W2011138700 @default.
- W4377609197 cites W2011597849 @default.
- W4377609197 cites W2012146758 @default.
- W4377609197 cites W2012355463 @default.
- W4377609197 cites W2013652157 @default.
- W4377609197 cites W2014802099 @default.
- W4377609197 cites W2016021980 @default.
- W4377609197 cites W2016777672 @default.
- W4377609197 cites W2019563323 @default.
- W4377609197 cites W2020444361 @default.
- W4377609197 cites W2023628640 @default.
- W4377609197 cites W2024274673 @default.
- W4377609197 cites W2027386977 @default.
- W4377609197 cites W2027488799 @default.
- W4377609197 cites W2027629727 @default.
- W4377609197 cites W2031534576 @default.
- W4377609197 cites W2035877779 @default.
- W4377609197 cites W2039375904 @default.
- W4377609197 cites W2041141691 @default.
- W4377609197 cites W2045525562 @default.
- W4377609197 cites W2045986290 @default.
- W4377609197 cites W2046792786 @default.
- W4377609197 cites W2048125120 @default.
- W4377609197 cites W2050469225 @default.
- W4377609197 cites W2052536599 @default.
- W4377609197 cites W2052976641 @default.
- W4377609197 cites W2054310411 @default.
- W4377609197 cites W2056521283 @default.
- W4377609197 cites W2056615294 @default.
- W4377609197 cites W2057623806 @default.
- W4377609197 cites W2057809835 @default.
- W4377609197 cites W2058590639 @default.
- W4377609197 cites W2060307790 @default.
- W4377609197 cites W2060528969 @default.
- W4377609197 cites W2065553596 @default.
- W4377609197 cites W2068675778 @default.
- W4377609197 cites W2070345146 @default.
- W4377609197 cites W2071952231 @default.
- W4377609197 cites W2073280587 @default.
- W4377609197 cites W2073741803 @default.
- W4377609197 cites W2074075725 @default.
- W4377609197 cites W2074469647 @default.
- W4377609197 cites W2081652191 @default.