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- W4377691350 endingPage "639" @default.
- W4377691350 startingPage "606" @default.
- W4377691350 abstract "Abstract Fungal infections are posing serious threat to healthcare system due to emerging resistance among available antifungal agents. Among available antifungal agents in clinical practice, azoles (diazole, 1,2,4‐triazole and tetrazole) remained most effective and widely prescribed antifungal agents. Now their associated side effects and emerging resistance pattern raised a need of new and potent antifungal agents. Lanosterol 14α‐demethylase (CYP51) is responsible for the oxidative removal of 14α‐methyl group of sterol precursors lanosterol and 24(28)‐methylene‐24,25‐dihydrolanosterol in ergosterol biosynthesis hence an essential component of fungal life cycle and prominent target for antifungal drug development. This review will shed light on various azole‐ as well as non‐azoles‐based derivatives as potential antifungal agents that target fungal CYP51. Review will provide deep insight about structure activity relationship, pharmacological outcomes, and interactions of derivatives with CYP51 at molecular level. It will help medicinal chemists working on antifungal development in designing more rational, potent, and safer antifungal agents by targeting fungal CYP51 for tackling emerging antifungal drug resistance." @default.
- W4377691350 created "2023-05-24" @default.
- W4377691350 creator A5007941660 @default.
- W4377691350 creator A5052226357 @default.
- W4377691350 creator A5053301917 @default.
- W4377691350 creator A5070106234 @default.
- W4377691350 creator A5078584120 @default.
- W4377691350 creator A5082759614 @default.
- W4377691350 date "2023-05-23" @default.
- W4377691350 modified "2023-10-18" @default.
- W4377691350 title "Recent advances in antifungal drug development targeting lanosterol 14α‐demethylase ( <scp>CYP51</scp> ): A comprehensive review with structural and molecular insights" @default.
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