Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377694429> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4377694429 abstract "Recent studies have confirmed that lung microvascular endothelial injury plays a critical role in the pathophysiology of COVID-19. Our group and others have demonstrated the beneficial effects of H2S in several pathological processes and provided a rationale for considering the therapeutic implications of H2S in COVID-19 therapy. Here, we evaluated the effect of the slow-releasing H2S donor, GYY4137, on the barrier function of a lung endothelial cell monolayer in vitro, after challenging the cells with plasma samples from COVID-19 patients or inactivated SARS-CoV-2 virus. We also assessed how the cytokine/chemokine profile of patients’ plasma, endothelial barrier permeability, and disease severity correlated with each other. Alterations of barrier permeability after treatments with patient plasma, inactivated virus, and GYY4137 were monitored and assessed by electrical impedance measurements in real-time. We present evidence that GYY4137 treatment reduced endothelial barrier permeability after plasma challenge and completely reversed the endothelial barrier disruption caused by inactivated SARS-CoV-2 virus. We also showed that disease severity correlated with the cytokine/chemokine profile of the plasma but not with barrier permeability changes in our assay. Overall, these data demonstrate that treatment with H2S-releasing compounds has the potential to ameliorate SARS-CoV-2–associated lung endothelial barrier disruption." @default.
- W4377694429 created "2023-05-24" @default.
- W4377694429 creator A5005923687 @default.
- W4377694429 creator A5008290640 @default.
- W4377694429 creator A5026987725 @default.
- W4377694429 creator A5040788314 @default.
- W4377694429 creator A5054479266 @default.
- W4377694429 creator A5064629201 @default.
- W4377694429 creator A5073183039 @default.
- W4377694429 creator A5075253541 @default.
- W4377694429 creator A5081327494 @default.
- W4377694429 creator A5083241611 @default.
- W4377694429 creator A5084823992 @default.
- W4377694429 creator A5092000520 @default.
- W4377694429 date "2023-05-23" @default.
- W4377694429 modified "2023-09-25" @default.
- W4377694429 title "Hydrogen Sulfide Ameliorates SARS-CoV-2–Associated Lung Endothelial Barrier Disruption" @default.
- W4377694429 doi "https://doi.org/10.20944/preprints202305.1639.v1" @default.
- W4377694429 hasPublicationYear "2023" @default.
- W4377694429 type Work @default.
- W4377694429 citedByCount "0" @default.
- W4377694429 crossrefType "posted-content" @default.
- W4377694429 hasAuthorship W4377694429A5005923687 @default.
- W4377694429 hasAuthorship W4377694429A5008290640 @default.
- W4377694429 hasAuthorship W4377694429A5026987725 @default.
- W4377694429 hasAuthorship W4377694429A5040788314 @default.
- W4377694429 hasAuthorship W4377694429A5054479266 @default.
- W4377694429 hasAuthorship W4377694429A5064629201 @default.
- W4377694429 hasAuthorship W4377694429A5073183039 @default.
- W4377694429 hasAuthorship W4377694429A5075253541 @default.
- W4377694429 hasAuthorship W4377694429A5081327494 @default.
- W4377694429 hasAuthorship W4377694429A5083241611 @default.
- W4377694429 hasAuthorship W4377694429A5084823992 @default.
- W4377694429 hasAuthorship W4377694429A5092000520 @default.
- W4377694429 hasBestOaLocation W43776944291 @default.
- W4377694429 hasConcept C10162356 @default.
- W4377694429 hasConcept C113045295 @default.
- W4377694429 hasConcept C120882062 @default.
- W4377694429 hasConcept C123012128 @default.
- W4377694429 hasConcept C126322002 @default.
- W4377694429 hasConcept C13373296 @default.
- W4377694429 hasConcept C142724271 @default.
- W4377694429 hasConcept C177779419 @default.
- W4377694429 hasConcept C185592680 @default.
- W4377694429 hasConcept C202751555 @default.
- W4377694429 hasConcept C203014093 @default.
- W4377694429 hasConcept C2776914184 @default.
- W4377694429 hasConcept C2776992346 @default.
- W4377694429 hasConcept C2777714996 @default.
- W4377694429 hasConcept C2778690821 @default.
- W4377694429 hasConcept C41625074 @default.
- W4377694429 hasConcept C51911345 @default.
- W4377694429 hasConcept C55493867 @default.
- W4377694429 hasConcept C68324877 @default.
- W4377694429 hasConcept C71924100 @default.
- W4377694429 hasConcept C86803240 @default.
- W4377694429 hasConcept C95444343 @default.
- W4377694429 hasConceptScore W4377694429C10162356 @default.
- W4377694429 hasConceptScore W4377694429C113045295 @default.
- W4377694429 hasConceptScore W4377694429C120882062 @default.
- W4377694429 hasConceptScore W4377694429C123012128 @default.
- W4377694429 hasConceptScore W4377694429C126322002 @default.
- W4377694429 hasConceptScore W4377694429C13373296 @default.
- W4377694429 hasConceptScore W4377694429C142724271 @default.
- W4377694429 hasConceptScore W4377694429C177779419 @default.
- W4377694429 hasConceptScore W4377694429C185592680 @default.
- W4377694429 hasConceptScore W4377694429C202751555 @default.
- W4377694429 hasConceptScore W4377694429C203014093 @default.
- W4377694429 hasConceptScore W4377694429C2776914184 @default.
- W4377694429 hasConceptScore W4377694429C2776992346 @default.
- W4377694429 hasConceptScore W4377694429C2777714996 @default.
- W4377694429 hasConceptScore W4377694429C2778690821 @default.
- W4377694429 hasConceptScore W4377694429C41625074 @default.
- W4377694429 hasConceptScore W4377694429C51911345 @default.
- W4377694429 hasConceptScore W4377694429C55493867 @default.
- W4377694429 hasConceptScore W4377694429C68324877 @default.
- W4377694429 hasConceptScore W4377694429C71924100 @default.
- W4377694429 hasConceptScore W4377694429C86803240 @default.
- W4377694429 hasConceptScore W4377694429C95444343 @default.
- W4377694429 hasLocation W43776944291 @default.
- W4377694429 hasOpenAccess W4377694429 @default.
- W4377694429 hasPrimaryLocation W43776944291 @default.
- W4377694429 hasRelatedWork W2064119580 @default.
- W4377694429 hasRelatedWork W2417591744 @default.
- W4377694429 hasRelatedWork W2892757637 @default.
- W4377694429 hasRelatedWork W2959982113 @default.
- W4377694429 hasRelatedWork W4251315559 @default.
- W4377694429 hasRelatedWork W4312187460 @default.
- W4377694429 hasRelatedWork W4313373333 @default.
- W4377694429 hasRelatedWork W4377694429 @default.
- W4377694429 hasRelatedWork W4381741498 @default.
- W4377694429 hasRelatedWork W53624447 @default.
- W4377694429 isParatext "false" @default.
- W4377694429 isRetracted "false" @default.
- W4377694429 workType "article" @default.