Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377694549> ?p ?o ?g. }
- W4377694549 abstract "Abstract Radiotherapy (RT) is an effective and widely applied cancer treatment strategy in clinic. However, it usually suffers from radioresistance of tumor cells and severs side effects of excessive radiation dose. Therefore, it is highly significant to improve radiotherapeutic performance and monitor real‐time tumor response, achieving precise and safe RT. Herein, an X‐ray responsive radio‐pharmaceutical molecule containing chemical radiosensitizers of diselenide and nitroimidazole (BBT‐IR/Se‐MN) is reported. BBT‐IR/Se‐MN exhibits enhanced radiotherapeutic effect via a multifaceted mechanisms and self‐monitoring ROS levels in tumors during RT. Under X‐ray irradiation, the diselenide produces high levels of ROS, leading to enhanced DNA damage of cancer cell. Afterwards, the nitroimidazole in the molecule inhibits the damaged DNA repair, offering a synergetic radiosensitization effect of cancer. Moreover, the probe shows low and high NIR‐II fluorescence ratios in the absence and presence of ROS, which is suitable for precise and quantitative monitoring of ROS during sensitized RT. The integrated system is successfully applied for radiosensitization and the early prediction of in vitro and in vivo RT efficacy." @default.
- W4377694549 created "2023-05-24" @default.
- W4377694549 creator A5012902167 @default.
- W4377694549 creator A5016622484 @default.
- W4377694549 creator A5017128653 @default.
- W4377694549 creator A5017858171 @default.
- W4377694549 creator A5041292939 @default.
- W4377694549 creator A5059084098 @default.
- W4377694549 creator A5076080012 @default.
- W4377694549 date "2023-06-13" @default.
- W4377694549 modified "2023-10-17" @default.
- W4377694549 title "A Radio‐Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species" @default.
- W4377694549 cites W2003601710 @default.
- W4377694549 cites W2052171115 @default.
- W4377694549 cites W2086527468 @default.
- W4377694549 cites W2156311525 @default.
- W4377694549 cites W2320066610 @default.
- W4377694549 cites W2610431184 @default.
- W4377694549 cites W2779029225 @default.
- W4377694549 cites W2804402143 @default.
- W4377694549 cites W2906405458 @default.
- W4377694549 cites W2968592740 @default.
- W4377694549 cites W2971196856 @default.
- W4377694549 cites W2993381787 @default.
- W4377694549 cites W3006551181 @default.
- W4377694549 cites W3010187002 @default.
- W4377694549 cites W3034985214 @default.
- W4377694549 cites W3039298350 @default.
- W4377694549 cites W3046701573 @default.
- W4377694549 cites W3047785641 @default.
- W4377694549 cites W3048725315 @default.
- W4377694549 cites W3120902778 @default.
- W4377694549 cites W3140531652 @default.
- W4377694549 cites W3172984574 @default.
- W4377694549 cites W3174451008 @default.
- W4377694549 cites W3180760057 @default.
- W4377694549 cites W3181207837 @default.
- W4377694549 cites W3185155048 @default.
- W4377694549 cites W3185456211 @default.
- W4377694549 cites W3199086518 @default.
- W4377694549 cites W3205046513 @default.
- W4377694549 cites W4200024702 @default.
- W4377694549 cites W4200038735 @default.
- W4377694549 cites W4200087219 @default.
- W4377694549 cites W4207012331 @default.
- W4377694549 cites W4210851296 @default.
- W4377694549 cites W4211008944 @default.
- W4377694549 cites W4220757092 @default.
- W4377694549 cites W4224944662 @default.
- W4377694549 cites W4280601960 @default.
- W4377694549 cites W4283009804 @default.
- W4377694549 cites W4284681231 @default.
- W4377694549 cites W4284972708 @default.
- W4377694549 cites W4291021607 @default.
- W4377694549 cites W4296795678 @default.
- W4377694549 cites W4296809688 @default.
- W4377694549 cites W4300002418 @default.
- W4377694549 doi "https://doi.org/10.1002/anie.202305744" @default.
- W4377694549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37221136" @default.
- W4377694549 hasPublicationYear "2023" @default.
- W4377694549 type Work @default.
- W4377694549 citedByCount "2" @default.
- W4377694549 countsByYear W43776945492023 @default.
- W4377694549 crossrefType "journal-article" @default.
- W4377694549 hasAuthorship W4377694549A5012902167 @default.
- W4377694549 hasAuthorship W4377694549A5016622484 @default.
- W4377694549 hasAuthorship W4377694549A5017128653 @default.
- W4377694549 hasAuthorship W4377694549A5017858171 @default.
- W4377694549 hasAuthorship W4377694549A5041292939 @default.
- W4377694549 hasAuthorship W4377694549A5059084098 @default.
- W4377694549 hasAuthorship W4377694549A5076080012 @default.
- W4377694549 hasConcept C111337013 @default.
- W4377694549 hasConcept C121332964 @default.
- W4377694549 hasConcept C121608353 @default.
- W4377694549 hasConcept C12554922 @default.
- W4377694549 hasConcept C126322002 @default.
- W4377694549 hasConcept C143425029 @default.
- W4377694549 hasConcept C150903083 @default.
- W4377694549 hasConcept C178790620 @default.
- W4377694549 hasConcept C185544564 @default.
- W4377694549 hasConcept C185592680 @default.
- W4377694549 hasConcept C202751555 @default.
- W4377694549 hasConcept C207001950 @default.
- W4377694549 hasConcept C2776428644 @default.
- W4377694549 hasConcept C2779680806 @default.
- W4377694549 hasConcept C48349386 @default.
- W4377694549 hasConcept C502942594 @default.
- W4377694549 hasConcept C509974204 @default.
- W4377694549 hasConcept C552990157 @default.
- W4377694549 hasConcept C553756173 @default.
- W4377694549 hasConcept C55493867 @default.
- W4377694549 hasConcept C58962609 @default.
- W4377694549 hasConcept C62520636 @default.
- W4377694549 hasConcept C71924100 @default.
- W4377694549 hasConcept C86803240 @default.
- W4377694549 hasConcept C91881484 @default.
- W4377694549 hasConcept C96232424 @default.
- W4377694549 hasConceptScore W4377694549C111337013 @default.
- W4377694549 hasConceptScore W4377694549C121332964 @default.
- W4377694549 hasConceptScore W4377694549C121608353 @default.