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- W4377694852 endingPage "114898" @default.
- W4377694852 startingPage "114898" @default.
- W4377694852 abstract "DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug delivery systems. These nanostructures can be functionalized with guests ranging from small molecules to proteins with precise spatial and stoichiometric control. This has enabled new strategies to manipulate drug activity and to engineer devices with novel therapeutic functionalities. Although existing studies have offered encouraging in vitro or pre-clinical proof-of-concepts, establishing mechanisms of in vivo delivery is the new frontier for nucleic-acid nanotechnologies. In this review, we first provide a summary of existing literature on the in vivo uses of DNA and RNA nanostructures. Based on their application areas, we discuss current models of nanoparticle delivery, and thereby highlight knowledge gaps on the in vivo interactions of nucleic-acid nanostructures. Finally, we describe techniques and strategies for investigating and engineering these interactions. Together, we propose a framework to establish in vivo design principles and advance the in vivo translation of nucleic-acid nanotechnologies." @default.
- W4377694852 created "2023-05-24" @default.
- W4377694852 creator A5017683580 @default.
- W4377694852 creator A5033499020 @default.
- W4377694852 creator A5067887461 @default.
- W4377694852 creator A5091499014 @default.
- W4377694852 date "2023-08-01" @default.
- W4377694852 modified "2023-10-16" @default.
- W4377694852 title "Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics" @default.
- W4377694852 cites W1515870710 @default.
- W4377694852 cites W1583595895 @default.
- W4377694852 cites W1587071366 @default.
- W4377694852 cites W1636022800 @default.
- W4377694852 cites W1814998281 @default.
- W4377694852 cites W1843302206 @default.
- W4377694852 cites W1845637086 @default.
- W4377694852 cites W1874889006 @default.
- W4377694852 cites W1963853602 @default.
- W4377694852 cites W1964535590 @default.
- W4377694852 cites W1965097716 @default.
- W4377694852 cites W1973831032 @default.
- W4377694852 cites W1975679096 @default.
- W4377694852 cites W1976104973 @default.
- W4377694852 cites W1976815031 @default.
- W4377694852 cites W1977338810 @default.
- W4377694852 cites W1977980568 @default.
- W4377694852 cites W1978158855 @default.
- W4377694852 cites W1983090757 @default.
- W4377694852 cites W1983321855 @default.
- W4377694852 cites W1985868513 @default.
- W4377694852 cites W1986001908 @default.
- W4377694852 cites W1987888610 @default.
- W4377694852 cites W1988812533 @default.
- W4377694852 cites W1990424094 @default.
- W4377694852 cites W1990796256 @default.
- W4377694852 cites W1991354544 @default.
- W4377694852 cites W1991701295 @default.
- W4377694852 cites W1993906884 @default.
- W4377694852 cites W1996343692 @default.
- W4377694852 cites W1997305459 @default.
- W4377694852 cites W2001154198 @default.
- W4377694852 cites W2001546121 @default.
- W4377694852 cites W2004899704 @default.
- W4377694852 cites W2005771030 @default.
- W4377694852 cites W2009116600 @default.
- W4377694852 cites W2009805582 @default.
- W4377694852 cites W2010756264 @default.
- W4377694852 cites W2010887032 @default.
- W4377694852 cites W2016361058 @default.
- W4377694852 cites W2021088564 @default.
- W4377694852 cites W2023711487 @default.
- W4377694852 cites W2024363509 @default.
- W4377694852 cites W2026864108 @default.
- W4377694852 cites W2029372030 @default.
- W4377694852 cites W2030699288 @default.
- W4377694852 cites W2030837990 @default.
- W4377694852 cites W2032088674 @default.
- W4377694852 cites W2032654453 @default.
- W4377694852 cites W2032680281 @default.
- W4377694852 cites W2034365190 @default.
- W4377694852 cites W2034750640 @default.
- W4377694852 cites W2034969680 @default.
- W4377694852 cites W2037555314 @default.
- W4377694852 cites W2038163024 @default.
- W4377694852 cites W2038412379 @default.
- W4377694852 cites W2049095447 @default.
- W4377694852 cites W2049490137 @default.
- W4377694852 cites W2052275870 @default.
- W4377694852 cites W2054981131 @default.
- W4377694852 cites W2057788156 @default.
- W4377694852 cites W2057910069 @default.
- W4377694852 cites W2058647478 @default.
- W4377694852 cites W2064882706 @default.
- W4377694852 cites W2066649475 @default.
- W4377694852 cites W2070380977 @default.
- W4377694852 cites W2072164275 @default.
- W4377694852 cites W2074544404 @default.
- W4377694852 cites W2076825506 @default.
- W4377694852 cites W2077850544 @default.
- W4377694852 cites W2083432826 @default.
- W4377694852 cites W2084951281 @default.
- W4377694852 cites W2086747295 @default.
- W4377694852 cites W2087468617 @default.
- W4377694852 cites W2088084709 @default.
- W4377694852 cites W2089079803 @default.
- W4377694852 cites W2091691458 @default.
- W4377694852 cites W2094854635 @default.
- W4377694852 cites W2094999215 @default.
- W4377694852 cites W2096162412 @default.
- W4377694852 cites W2096423541 @default.
- W4377694852 cites W2098263168 @default.
- W4377694852 cites W2099580736 @default.
- W4377694852 cites W2100473511 @default.
- W4377694852 cites W2102606231 @default.
- W4377694852 cites W2104061650 @default.
- W4377694852 cites W2105824455 @default.
- W4377694852 cites W2106267572 @default.
- W4377694852 cites W2107172548 @default.