FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377696389> ?p ?o ?g. }

• W4377696389 endingPage "109524" @default.
• W4377696389 startingPage "109524" @default.
• W4377696389 abstract "Despite the known morbidity associated with activated PI3Kδ syndrome (APDS), little is understood about the healthcare resource utilization (HRU) attributable to this condition. To describe HRU and treatment patterns of patients with APDS by age group (≤11 and ≥12 yrs). Patients with APDS were identified via genetic testing and tokenized to the Symphony Health Integrated Dataverse database comprising medical/pharmacy claims (10/1/2015–3/31/2021). HRU rates (hospitalizations, emergency room [ER], outpatient, and other visits) per person-year, main reason for HRU visit, and treatment patterns were assessed from the start of patients’ clinical activity to the earliest of end of clinical activity or data availability (observation period). Of 31 patients with APDS identified, 14 were ≤11 yrs and 17 were ≥12 yrs. The mean±SD observation period was 3.9 ±2.1 and 5.2 ± 1.8 yrs, respectively; mean age was 3.9 ± 2.7 and 29.4 ± 13.1 yrs, respectively. Common clinical manifestations in ≤11 yrs included lymphoproliferation (71.4%), fever (64.3%), allergy (57.1%), otitis media (50.0%), diarrhea (21.4%), and lymphoma (7.1%). Common clinical manifestations in ≥12 yrs included sinusitis (58.8%), bronchitis (58.8%), allergy (47.1%), diarrhea (23.5%), and lymphoma (17.6%). Outpatient visit rates were high overall; ER visits and hospitalization rates were low in both groups, whereas other visit rates were high in ≥12 yrs (Figure 1). Immunoglobulin replacement therapy (IRT)-related HRU accounted for 14.4% and 17.9% of outpatient visits in ≤11 yrs and ≥12 yrs, respectively, and 36.6% and 34.3% of other visits in ≤11 yrs and ≥12 yrs, respectively. Reasons for outpatient visits included enlarged lymph nodes and otitis media in ≤11 yrs and long-term drug therapy, common variable immunodeficiency, and acute sinusitis in ≥12 yrs. IRT was used by 42.9% and 70.6% in ≤11 yrs and ≥12 yrs, respectively. Antibiotic, corticosteroid, and mTor inhibitors were used by 92.9% and 88.2%, 78.6% and 76.5%, and 21.4% and 11.8% in ≤11 yrs and ≥12 yrs, respectively; no rituximab use was observed. Download : Download high-res image (50KB)Download : Download full-size imageFigure 1. Healthcare Utilization Resource Figure 1. Healthcare Utilization Resource APDS presents with various complex clinical manifestations requiring intervention. Among patients analyzed, outpatient and other visits were the most commonly used healthcare resources and were often associated with respiratory disease and immunodeficiency management. To our knowledge, this is the first study to assess HRU among patients with APDS using administrative claims data." @default.
• W4377696389 created "2023-05-24" @default.
• W4377696389 creator A5012415127 @default.
• W4377696389 creator A5017007793 @default.
• W4377696389 creator A5017834828 @default.
• W4377696389 creator A5044477191 @default.
• W4377696389 creator A5061998147 @default.
• W4377696389 creator A5090405389 @default.
• W4377696389 date "2023-05-01" @default.
• W4377696389 modified "2023-10-17" @default.
• W4377696389 title "Healthcare Resource Utilization Among Patients With Activated PI3Kδ Syndrome in the United States: A Real-world Assessment by Patient Age" @default.
• W4377696389 doi "https://doi.org/10.1016/j.clim.2023.109524" @default.
• W4377696389 hasPublicationYear "2023" @default.
• W4377696389 type Work @default.
• W4377696389 citedByCount "0" @default.
• W4377696389 crossrefType "journal-article" @default.
• W4377696389 hasAuthorship W4377696389A5012415127 @default.
• W4377696389 hasAuthorship W4377696389A5017007793 @default.
• W4377696389 hasAuthorship W4377696389A5017834828 @default.
• W4377696389 hasAuthorship W4377696389A5044477191 @default.
• W4377696389 hasAuthorship W4377696389A5061998147 @default.
• W4377696389 hasAuthorship W4377696389A5090405389 @default.
• W4377696389 hasConcept C126322002 @default.
• W4377696389 hasConcept C141071460 @default.
• W4377696389 hasConcept C187212893 @default.
• W4377696389 hasConcept C2776439223 @default.
• W4377696389 hasConcept C2778570526 @default.
• W4377696389 hasConcept C2779993553 @default.
• W4377696389 hasConcept C71924100 @default.
• W4377696389 hasConceptScore W4377696389C126322002 @default.
• W4377696389 hasConceptScore W4377696389C141071460 @default.
• W4377696389 hasConceptScore W4377696389C187212893 @default.
• W4377696389 hasConceptScore W4377696389C2776439223 @default.
• W4377696389 hasConceptScore W4377696389C2778570526 @default.
• W4377696389 hasConceptScore W4377696389C2779993553 @default.
• W4377696389 hasConceptScore W4377696389C71924100 @default.
• W4377696389 hasLocation W43776963891 @default.
• W4377696389 hasOpenAccess W4377696389 @default.
• W4377696389 hasPrimaryLocation W43776963891 @default.
• W4377696389 hasRelatedWork W2072065445 @default.
• W4377696389 hasRelatedWork W2072896213 @default.
• W4377696389 hasRelatedWork W225167318 @default.
• W4377696389 hasRelatedWork W2411342241 @default.
• W4377696389 hasRelatedWork W2472410638 @default.
• W4377696389 hasRelatedWork W2788405903 @default.
• W4377696389 hasRelatedWork W3002424684 @default.
• W4377696389 hasRelatedWork W3082785252 @default.
• W4377696389 hasRelatedWork W4214822825 @default.
• W4377696389 hasRelatedWork W4310045852 @default.
• W4377696389 hasVolume "250" @default.
• W4377696389 isParatext "false" @default.
• W4377696389 isRetracted "false" @default.
• W4377696389 workType "article" @default.