Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377822057> ?p ?o ?g. }
- W4377822057 abstract "Type 2 Diabetes (T2D) is often managed with metformin as the drug of choice. While it is effective overall, many patients progress to exhibit complications. Strategic drug combinations to tackle this problem would be useful. We constructed a genome-wide protein-protein interaction network capturing a global perspective of perturbations in diabetes by integrating T2D subjects' transcriptomic data. We computed a 'frequently perturbed subnetwork' in T2D that captures common perturbations across tissue types and mapped the possible effects of Metformin onto it. We then identified a set of remaining T2D perturbations and potential drug targets among them, related to oxidative stress and hypercholesterolemia. We then identified Probucol as the potential co-drug for adjunct therapy with Metformin and evaluated the efficacy of the combination in a rat model of diabetes. We find Metformin-Probucol at 5:0.5 mg/kg effective in restoring near-normal serum glucose, lipid, and cholesterol levels." @default.
- W4377822057 created "2023-05-24" @default.
- W4377822057 creator A5007094840 @default.
- W4377822057 creator A5008621089 @default.
- W4377822057 creator A5035665042 @default.
- W4377822057 creator A5085789773 @default.
- W4377822057 creator A5088371167 @default.
- W4377822057 creator A5092002448 @default.
- W4377822057 date "2023-05-23" @default.
- W4377822057 modified "2023-10-18" @default.
- W4377822057 title "Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes" @default.
- W4377822057 cites W1480729244 @default.
- W4377822057 cites W1985919873 @default.
- W4377822057 cites W1997930168 @default.
- W4377822057 cites W2002223907 @default.
- W4377822057 cites W2009274826 @default.
- W4377822057 cites W2017735458 @default.
- W4377822057 cites W2041112805 @default.
- W4377822057 cites W2048488935 @default.
- W4377822057 cites W2053922714 @default.
- W4377822057 cites W2054931962 @default.
- W4377822057 cites W2058539819 @default.
- W4377822057 cites W2065903447 @default.
- W4377822057 cites W2067010864 @default.
- W4377822057 cites W2068687134 @default.
- W4377822057 cites W2070050178 @default.
- W4377822057 cites W2091811232 @default.
- W4377822057 cites W2105841205 @default.
- W4377822057 cites W2114041992 @default.
- W4377822057 cites W2146512944 @default.
- W4377822057 cites W2147816535 @default.
- W4377822057 cites W2151223245 @default.
- W4377822057 cites W2154471226 @default.
- W4377822057 cites W2161026220 @default.
- W4377822057 cites W2165641442 @default.
- W4377822057 cites W2170146596 @default.
- W4377822057 cites W2200128223 @default.
- W4377822057 cites W2294516783 @default.
- W4377822057 cites W2417211481 @default.
- W4377822057 cites W2586070549 @default.
- W4377822057 cites W2743010525 @default.
- W4377822057 cites W2891980308 @default.
- W4377822057 cites W2923189206 @default.
- W4377822057 cites W2941308472 @default.
- W4377822057 cites W2946689665 @default.
- W4377822057 cites W2980638675 @default.
- W4377822057 cites W3004838676 @default.
- W4377822057 cites W3005583344 @default.
- W4377822057 cites W3033833474 @default.
- W4377822057 cites W3097279041 @default.
- W4377822057 cites W4212764622 @default.
- W4377822057 cites W4251588077 @default.
- W4377822057 doi "https://doi.org/10.1038/s41540-023-00275-8" @default.
- W4377822057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37221264" @default.
- W4377822057 hasPublicationYear "2023" @default.
- W4377822057 type Work @default.
- W4377822057 citedByCount "0" @default.
- W4377822057 crossrefType "journal-article" @default.
- W4377822057 hasAuthorship W4377822057A5007094840 @default.
- W4377822057 hasAuthorship W4377822057A5008621089 @default.
- W4377822057 hasAuthorship W4377822057A5035665042 @default.
- W4377822057 hasAuthorship W4377822057A5085789773 @default.
- W4377822057 hasAuthorship W4377822057A5088371167 @default.
- W4377822057 hasAuthorship W4377822057A5092002448 @default.
- W4377822057 hasBestOaLocation W43778220571 @default.
- W4377822057 hasConcept C104317684 @default.
- W4377822057 hasConcept C126322002 @default.
- W4377822057 hasConcept C134018914 @default.
- W4377822057 hasConcept C150194340 @default.
- W4377822057 hasConcept C162317418 @default.
- W4377822057 hasConcept C2776167589 @default.
- W4377822057 hasConcept C2777180221 @default.
- W4377822057 hasConcept C2778163477 @default.
- W4377822057 hasConcept C2780035454 @default.
- W4377822057 hasConcept C2780323712 @default.
- W4377822057 hasConcept C2910068830 @default.
- W4377822057 hasConcept C55493867 @default.
- W4377822057 hasConcept C555293320 @default.
- W4377822057 hasConcept C60644358 @default.
- W4377822057 hasConcept C70721500 @default.
- W4377822057 hasConcept C71924100 @default.
- W4377822057 hasConcept C86803240 @default.
- W4377822057 hasConcept C98274493 @default.
- W4377822057 hasConceptScore W4377822057C104317684 @default.
- W4377822057 hasConceptScore W4377822057C126322002 @default.
- W4377822057 hasConceptScore W4377822057C134018914 @default.
- W4377822057 hasConceptScore W4377822057C150194340 @default.
- W4377822057 hasConceptScore W4377822057C162317418 @default.
- W4377822057 hasConceptScore W4377822057C2776167589 @default.
- W4377822057 hasConceptScore W4377822057C2777180221 @default.
- W4377822057 hasConceptScore W4377822057C2778163477 @default.
- W4377822057 hasConceptScore W4377822057C2780035454 @default.
- W4377822057 hasConceptScore W4377822057C2780323712 @default.
- W4377822057 hasConceptScore W4377822057C2910068830 @default.
- W4377822057 hasConceptScore W4377822057C55493867 @default.
- W4377822057 hasConceptScore W4377822057C555293320 @default.
- W4377822057 hasConceptScore W4377822057C60644358 @default.
- W4377822057 hasConceptScore W4377822057C70721500 @default.
- W4377822057 hasConceptScore W4377822057C71924100 @default.
- W4377822057 hasConceptScore W4377822057C86803240 @default.