FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377939739> ?p ?o ?g. }

• W4377939739 abstract "COVID-19 has spread all over the world which poses a serious threat to social economic development and public health. Despite enormous progress has been made in the prevention and treatment of COVID-19, the specific mechanism and biomarker related to disease severity or prognosis have not been clarified yet. Our study intended to further explore the diagnostic markers of COVID-19 and their relationship with serum immunology by bioinformatics analysis. The datasets about COVID-19 were downloaded from the Gene Expression Omnibus (GEO) dataset. The differentially expressed genes (DEGs) were selected via the limma package. Then, weighted gene co-expression network analysis (WGCNA) was conducted to identify the critical module associated with the clinic status. The intersection DEGs were processed for further enrichment analysis. The final diagnostic genes for COVID-19 were selected and verified through special bioinformatics algorithms. There were significant DEGs between the normal and COVID-19 patients. These genes were mainly enriched in cell cycle, complement and coagulation cascade, extracellular matrix (ECM) receptor interaction, and the P53 signaling pathway. As much as 357 common intersected DEGs were selected in the end. These DEGs were enriched in organelle fission, mitotic cell cycle phase transition, DNA helicase activity, cell cycle, cellular senescence, and P53 signaling pathway. Our study also identified CDC25A, PDCD6, and YWAHE were potential diagnostic markers of COVID-19 with the AUC (area under curve), 0.958 (95% CI 0.920-0.988), 0.941(95% CI 0.892-0.980), and 0.929 (95% CI 0.880-0.971). Moreover, CDC25A, PDCD6, and YWAHE were correlated with plasma cells, macrophages M0, T cells CD4 memory resting, T cells CD8, dendritic cells, and NK cells. Our study discovered that CDC25A, PDCD6, and YWAHE can be used as diagnostic markers for COVID-19. Moreover, these biomarkers were also closely associated with immune cell infiltration, which plays a pivotal role in the diagnosis and progression of COVID-19." @default.
• W4377939739 created "2023-05-25" @default.
• W4377939739 creator A5000427196 @default.
• W4377939739 creator A5010692353 @default.
• W4377939739 creator A5034484116 @default.
• W4377939739 date "2023-05-24" @default.
• W4377939739 modified "2023-09-28" @default.
• W4377939739 title "Identification of Key Genes Related to Immune Cells in Patients with COVID-19 Via Integrated Bioinformatics-Based Analysis" @default.
• W4377939739 cites W1522008008 @default.
• W4377939739 cites W1967637444 @default.
• W4377939739 cites W1988532315 @default.
• W4377939739 cites W2028692389 @default.
• W4377939739 cites W2038436363 @default.
• W4377939739 cites W2040407266 @default.
• W4377939739 cites W2047683179 @default.
• W4377939739 cites W2062219923 @default.
• W4377939739 cites W2072158757 @default.
• W4377939739 cites W2076082087 @default.
• W4377939739 cites W2138657695 @default.
• W4377939739 cites W2147152880 @default.
• W4377939739 cites W2238877049 @default.
• W4377939739 cites W2240067531 @default.
• W4377939739 cites W2550010984 @default.
• W4377939739 cites W2752942423 @default.
• W4377939739 cites W2884503686 @default.
• W4377939739 cites W3008090866 @default.
• W4377939739 cites W3014294089 @default.
• W4377939739 cites W3018811022 @default.
• W4377939739 cites W3019086896 @default.
• W4377939739 cites W3020773974 @default.
• W4377939739 cites W3025053074 @default.
• W4377939739 cites W3025232799 @default.
• W4377939739 cites W3026764413 @default.
• W4377939739 cites W3030871984 @default.
• W4377939739 cites W3032774217 @default.
• W4377939739 cites W3041985244 @default.
• W4377939739 cites W3081284165 @default.
• W4377939739 cites W3092136311 @default.
• W4377939739 cites W3092577522 @default.
• W4377939739 cites W3094064847 @default.
• W4377939739 cites W3111593829 @default.
• W4377939739 cites W3193191879 @default.
• W4377939739 cites W3196024952 @default.
• W4377939739 cites W4200231439 @default.
• W4377939739 cites W4220886379 @default.
• W4377939739 cites W4221085796 @default.
• W4377939739 cites W4224209612 @default.
• W4377939739 cites W4280509840 @default.
• W4377939739 cites W4280514733 @default.
• W4377939739 cites W4283384753 @default.
• W4377939739 cites W4283781589 @default.
• W4377939739 cites W4284992727 @default.
• W4377939739 cites W4285401846 @default.
• W4377939739 cites W4286321152 @default.
• W4377939739 cites W4289544781 @default.
• W4377939739 cites W4292163701 @default.
• W4377939739 cites W4292315897 @default.
• W4377939739 cites W4293537886 @default.
• W4377939739 doi "https://doi.org/10.1007/s10528-023-10400-1" @default.
• W4377939739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37222960" @default.
• W4377939739 hasPublicationYear "2023" @default.
• W4377939739 type Work @default.
• W4377939739 citedByCount "0" @default.
• W4377939739 crossrefType "journal-article" @default.
• W4377939739 hasAuthorship W4377939739A5000427196 @default.
• W4377939739 hasAuthorship W4377939739A5010692353 @default.
• W4377939739 hasAuthorship W4377939739A5034484116 @default.
• W4377939739 hasBestOaLocation W43779397391 @default.
• W4377939739 hasConcept C104317684 @default.
• W4377939739 hasConcept C29537977 @default.
• W4377939739 hasConcept C54355233 @default.
• W4377939739 hasConcept C60644358 @default.
• W4377939739 hasConcept C70721500 @default.
• W4377939739 hasConcept C86803240 @default.
• W4377939739 hasConceptScore W4377939739C104317684 @default.
• W4377939739 hasConceptScore W4377939739C29537977 @default.
• W4377939739 hasConceptScore W4377939739C54355233 @default.
• W4377939739 hasConceptScore W4377939739C60644358 @default.
• W4377939739 hasConceptScore W4377939739C70721500 @default.
• W4377939739 hasConceptScore W4377939739C86803240 @default.
• W4377939739 hasLocation W43779397391 @default.
• W4377939739 hasLocation W43779397392 @default.
• W4377939739 hasLocation W43779397393 @default.
• W4377939739 hasLocation W43779397394 @default.
• W4377939739 hasOpenAccess W4377939739 @default.
• W4377939739 hasPrimaryLocation W43779397391 @default.
• W4377939739 hasRelatedWork W1828691184 @default.
• W4377939739 hasRelatedWork W1903732681 @default.
• W4377939739 hasRelatedWork W1991523530 @default.
• W4377939739 hasRelatedWork W2001677368 @default.
• W4377939739 hasRelatedWork W2002128513 @default.
• W4377939739 hasRelatedWork W2020824267 @default.
• W4377939739 hasRelatedWork W2057739827 @default.
• W4377939739 hasRelatedWork W2120393042 @default.
• W4377939739 hasRelatedWork W2171277769 @default.
• W4377939739 hasRelatedWork W2092874662 @default.
• W4377939739 isParatext "false" @default.
• W4377939739 isRetracted "false" @default.
• W4377939739 workType "article" @default.