FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377939888> ?p ?o ?g. }

• W4377939888 endingPage "1095" @default.
• W4377939888 startingPage "1084" @default.
• W4377939888 abstract "Polyamidoamine (PAMAM) dendrimers are among the most studied cationic polymers as non-viral gene delivery vectors. However, an ideal PAMAM-based gene delivery vector is still missing due to the high manufacturing costs and non-negligible cytotoxicity associated with the use of high-generation dendrimers, whereas low-generation dendrimers are far from displaying efficient gene transfection. In order to cover this gap in the literature, in this study, we propose the functionalization of the outer primary amines of PAMAM G2 and PAMAM G4 with building blocks bearing fluorinated moieties along with a guanidino functional group. We have designed and synthetized two fluorinated arginine (Arg)-based Michael acceptors which were straightforwardly clicked to PAMAM dendrimers without the need for coupling reagents and/or catalysts. The obtained conjugates, in particular, derivative 1 formed starting from the low-cost PAMAM G2 and a building block bearing two trifluoromethyl groups, were able to efficiently complex plasmid DNA, had negligible cytotoxicity, and showed improved gene transfection efficiency as compared to undecorated PAMAM dendrimers and a corresponding unfluorinated PAMAM-Arg derivative, with derivative 1 being two orders of magnitude more efficient than the gold standard branched polyethylenimine, bPEI, 25 kDa. These results highlight the importance of the presence of trifluoromethyl moieties for both gene transfection and a possible future application in 19F magnetic resonance imaging." @default.
• W4377939888 created "2023-05-25" @default.
• W4377939888 creator A5019973723 @default.
• W4377939888 creator A5049111512 @default.
• W4377939888 creator A5071358322 @default.
• W4377939888 creator A5080488300 @default.
• W4377939888 date "2023-05-23" @default.
• W4377939888 modified "2023-09-30" @default.
• W4377939888 title "Selectively Fluorinated PAMAM–Arginine Conjugates as Gene Delivery Vectors" @default.
• W4377939888 cites W1623257362 @default.
• W4377939888 cites W1972890442 @default.
• W4377939888 cites W1974242784 @default.
• W4377939888 cites W1982194357 @default.
• W4377939888 cites W1988020745 @default.
• W4377939888 cites W2001933188 @default.
• W4377939888 cites W2002501325 @default.
• W4377939888 cites W2004262236 @default.
• W4377939888 cites W2008971936 @default.
• W4377939888 cites W2009285734 @default.
• W4377939888 cites W2011085652 @default.
• W4377939888 cites W2019375221 @default.
• W4377939888 cites W2026938196 @default.
• W4377939888 cites W2028065660 @default.
• W4377939888 cites W2039879202 @default.
• W4377939888 cites W2047344431 @default.
• W4377939888 cites W2060637142 @default.
• W4377939888 cites W2080666913 @default.
• W4377939888 cites W2082774852 @default.
• W4377939888 cites W2084121938 @default.
• W4377939888 cites W2090458823 @default.
• W4377939888 cites W2091039781 @default.
• W4377939888 cites W2095482077 @default.
• W4377939888 cites W2099540110 @default.
• W4377939888 cites W2107848765 @default.
• W4377939888 cites W2117383442 @default.
• W4377939888 cites W2183660437 @default.
• W4377939888 cites W2315147297 @default.
• W4377939888 cites W2323511001 @default.
• W4377939888 cites W2531550383 @default.
• W4377939888 cites W2547070030 @default.
• W4377939888 cites W2560775235 @default.
• W4377939888 cites W2573071355 @default.
• W4377939888 cites W2580035316 @default.
• W4377939888 cites W2594306226 @default.
• W4377939888 cites W2625405100 @default.
• W4377939888 cites W2744156171 @default.
• W4377939888 cites W2891559169 @default.
• W4377939888 cites W2937364539 @default.
• W4377939888 cites W2971073420 @default.
• W4377939888 cites W2975753220 @default.
• W4377939888 cites W2996388283 @default.
• W4377939888 cites W3007796728 @default.
• W4377939888 cites W3016531355 @default.
• W4377939888 cites W3084370958 @default.
• W4377939888 cites W3133550433 @default.
• W4377939888 cites W3165349279 @default.
• W4377939888 cites W4212782791 @default.
• W4377939888 cites W60021579 @default.
• W4377939888 cites W82473259 @default.
• W4377939888 doi "https://doi.org/10.1021/acs.bioconjchem.3c00139" @default.
• W4377939888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37221455" @default.
• W4377939888 hasPublicationYear "2023" @default.
• W4377939888 type Work @default.
• W4377939888 citedByCount "1" @default.
• W4377939888 countsByYear W43779398882023 @default.
• W4377939888 crossrefType "journal-article" @default.
• W4377939888 hasAuthorship W4377939888A5019973723 @default.
• W4377939888 hasAuthorship W4377939888A5049111512 @default.
• W4377939888 hasAuthorship W4377939888A5071358322 @default.
• W4377939888 hasAuthorship W4377939888A5080488300 @default.
• W4377939888 hasBestOaLocation W43779398881 @default.
• W4377939888 hasConcept C104317684 @default.
• W4377939888 hasConcept C109316439 @default.
• W4377939888 hasConcept C115537861 @default.
• W4377939888 hasConcept C134306372 @default.
• W4377939888 hasConcept C135983454 @default.
• W4377939888 hasConcept C147789679 @default.
• W4377939888 hasConcept C183882617 @default.
• W4377939888 hasConcept C185592680 @default.
• W4377939888 hasConcept C188027245 @default.
• W4377939888 hasConcept C197336794 @default.
• W4377939888 hasConcept C202751555 @default.
• W4377939888 hasConcept C21951064 @default.
• W4377939888 hasConcept C2775925850 @default.
• W4377939888 hasConcept C33923547 @default.
• W4377939888 hasConcept C54009773 @default.
• W4377939888 hasConcept C55493867 @default.
• W4377939888 hasConcept C55637122 @default.
• W4377939888 hasConceptScore W4377939888C104317684 @default.
• W4377939888 hasConceptScore W4377939888C109316439 @default.
• W4377939888 hasConceptScore W4377939888C115537861 @default.
• W4377939888 hasConceptScore W4377939888C134306372 @default.
• W4377939888 hasConceptScore W4377939888C135983454 @default.
• W4377939888 hasConceptScore W4377939888C147789679 @default.
• W4377939888 hasConceptScore W4377939888C183882617 @default.
• W4377939888 hasConceptScore W4377939888C185592680 @default.
• W4377939888 hasConceptScore W4377939888C188027245 @default.
• W4377939888 hasConceptScore W4377939888C197336794 @default.

• next