Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377940892> ?p ?o ?g. }
- W4377940892 endingPage "2864" @default.
- W4377940892 startingPage "2851" @default.
- W4377940892 abstract "Therapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming at robust T cell responses. SLPs linked to the Amplivant® adjuvant (Amplivant-SLP) have shown effective delivery to dendritic cells, resulting in improved immunogenicity in mice. We have now tested virosomes as a delivery vehicle for SLPs. Virosomes are nanoparticles made from influenza virus membranes and have been used as vaccines for a variety of antigens. Amplivant-SLP virosomes induced the expansion of more antigen-specific CD8 + T memory cells in ex vivo experiments with human PBMCs than Amplivant-SLP conjugates alone. The immune response could be further improved by including the adjuvants QS-21 and 3D-PHAD in the virosomal membrane. In these experiments, the SLPs were anchored in the membrane through the hydrophobic Amplivant adjuvant. In a therapeutic mouse model of HPV16 E6/E7+ cancer, mice were vaccinated with virosomes loaded with either Amplivant-conjugated SLPs or lipid-coupled SLPs. Vaccination with both types of virosomes significantly improved the control of tumor outgrowth, leading to elimination of the tumors in about half the animals for the best combinations of adjuvants and to their survival beyond 100 days." @default.
- W4377940892 created "2023-05-25" @default.
- W4377940892 creator A5001033160 @default.
- W4377940892 creator A5010866146 @default.
- W4377940892 creator A5021526278 @default.
- W4377940892 creator A5021774824 @default.
- W4377940892 creator A5035565968 @default.
- W4377940892 creator A5044060069 @default.
- W4377940892 creator A5044218378 @default.
- W4377940892 creator A5075649585 @default.
- W4377940892 creator A5082644636 @default.
- W4377940892 creator A5090086602 @default.
- W4377940892 date "2023-05-24" @default.
- W4377940892 modified "2023-10-14" @default.
- W4377940892 title "Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides" @default.
- W4377940892 cites W1519576779 @default.
- W4377940892 cites W1918446688 @default.
- W4377940892 cites W1938515409 @default.
- W4377940892 cites W1972589975 @default.
- W4377940892 cites W1988097468 @default.
- W4377940892 cites W1991701295 @default.
- W4377940892 cites W2002623789 @default.
- W4377940892 cites W2016445477 @default.
- W4377940892 cites W2027993940 @default.
- W4377940892 cites W2030692234 @default.
- W4377940892 cites W2054953556 @default.
- W4377940892 cites W2070696836 @default.
- W4377940892 cites W2071244674 @default.
- W4377940892 cites W2073873353 @default.
- W4377940892 cites W2084480062 @default.
- W4377940892 cites W2096866753 @default.
- W4377940892 cites W2114789433 @default.
- W4377940892 cites W2154658844 @default.
- W4377940892 cites W2169643581 @default.
- W4377940892 cites W2174836001 @default.
- W4377940892 cites W2329751835 @default.
- W4377940892 cites W2409412282 @default.
- W4377940892 cites W2518310626 @default.
- W4377940892 cites W2588650213 @default.
- W4377940892 cites W2769095299 @default.
- W4377940892 cites W2803559194 @default.
- W4377940892 cites W2810044459 @default.
- W4377940892 cites W2892876553 @default.
- W4377940892 cites W2903826135 @default.
- W4377940892 cites W2935351976 @default.
- W4377940892 cites W2948246289 @default.
- W4377940892 cites W2949287265 @default.
- W4377940892 cites W3009012005 @default.
- W4377940892 cites W3012160408 @default.
- W4377940892 cites W3114792224 @default.
- W4377940892 cites W4206384730 @default.
- W4377940892 cites W4213388872 @default.
- W4377940892 cites W4236618054 @default.
- W4377940892 cites W4295136475 @default.
- W4377940892 cites W4306810804 @default.
- W4377940892 doi "https://doi.org/10.1007/s00262-023-03462-y" @default.
- W4377940892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37222770" @default.
- W4377940892 hasPublicationYear "2023" @default.
- W4377940892 type Work @default.
- W4377940892 citedByCount "0" @default.
- W4377940892 crossrefType "journal-article" @default.
- W4377940892 hasAuthorship W4377940892A5001033160 @default.
- W4377940892 hasAuthorship W4377940892A5010866146 @default.
- W4377940892 hasAuthorship W4377940892A5021526278 @default.
- W4377940892 hasAuthorship W4377940892A5021774824 @default.
- W4377940892 hasAuthorship W4377940892A5035565968 @default.
- W4377940892 hasAuthorship W4377940892A5044060069 @default.
- W4377940892 hasAuthorship W4377940892A5044218378 @default.
- W4377940892 hasAuthorship W4377940892A5075649585 @default.
- W4377940892 hasAuthorship W4377940892A5082644636 @default.
- W4377940892 hasAuthorship W4377940892A5090086602 @default.
- W4377940892 hasBestOaLocation W43779408921 @default.
- W4377940892 hasConcept C147483822 @default.
- W4377940892 hasConcept C159047783 @default.
- W4377940892 hasConcept C167672396 @default.
- W4377940892 hasConcept C203014093 @default.
- W4377940892 hasConcept C22070199 @default.
- W4377940892 hasConcept C2777701055 @default.
- W4377940892 hasConcept C2777863537 @default.
- W4377940892 hasConcept C2778378633 @default.
- W4377940892 hasConcept C2780868878 @default.
- W4377940892 hasConcept C502942594 @default.
- W4377940892 hasConcept C71924100 @default.
- W4377940892 hasConcept C86803240 @default.
- W4377940892 hasConcept C8891405 @default.
- W4377940892 hasConceptScore W4377940892C147483822 @default.
- W4377940892 hasConceptScore W4377940892C159047783 @default.
- W4377940892 hasConceptScore W4377940892C167672396 @default.
- W4377940892 hasConceptScore W4377940892C203014093 @default.
- W4377940892 hasConceptScore W4377940892C22070199 @default.
- W4377940892 hasConceptScore W4377940892C2777701055 @default.
- W4377940892 hasConceptScore W4377940892C2777863537 @default.
- W4377940892 hasConceptScore W4377940892C2778378633 @default.
- W4377940892 hasConceptScore W4377940892C2780868878 @default.
- W4377940892 hasConceptScore W4377940892C502942594 @default.
- W4377940892 hasConceptScore W4377940892C71924100 @default.
- W4377940892 hasConceptScore W4377940892C86803240 @default.
- W4377940892 hasConceptScore W4377940892C8891405 @default.