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• W4377941045 endingPage "426" @default.
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• W4377941045 abstract "Introduction: Callous-unemotional (CU) traits are a youth antisocial phenotype hypothesized to be a result of differences in the integration of multiple brain systems. However, mechanistic insights into these brain systems are a continued challenge. Where prior work describes activation and connectivity, new mechanistic insights into the brain's functional connectome can be derived by removing nodes and quantifying changes in network properties (hereafter referred to as computational lesioning) to characterize connectome resilience and vulnerability. Methods: Here, we study the resilience of connectome integration in CU traits by estimating changes in efficiency after computationally lesioning individual-level connectomes. From resting-state data of 86 participants (48% female, age 14.52 ± 1.31) drawn from the Nathan Kline institute's Rockland study, individual-level connectomes were estimated using graphical lasso. Computational lesioning was conducted both sequentially and by targeting global and local hubs. Elastic net regression was applied to determine how these changes explained variance in CU traits. Follow-up analyses characterized modeled node hubs, examined moderation, determined impact of targeting, and decoded the brain mask by comparing regions to meta-analytic maps. Results: Elastic net regression revealed that computational lesioning of 23 nodes, network modularity, and Tanner stage explained variance in CU traits. Hub assignment of selected hubs differed at higher CU traits. No evidence for moderation between simulated lesioning and CU traits was found. Targeting global hubs increased efficiency and targeting local hubs had no effect at higher CU traits. Identified brain mask meta-analytically associated with more emotion and cognitive terms. Although reliable patterns were found across participants, adolescent brains were heterogeneous even for those with a similar CU traits score. Conclusion: Adolescent brain response to simulated lesioning revealed a pattern of connectome resiliency and vulnerability that explains variance in CU traits, which can aid prediction of youth at greater risk for higher CU traits. Mechanistic insights into the differences in multiple brain systems underlying callous-unemotional (CU) traits represent a continued challenge. By examining changes in the brain functional connectome after computationally lesioning that node and examining changes in network properties, we can derive unique mechanistic insights. By applying this method to individual-level connectomes, we revealed a pattern of vulnerability and resiliency in the individual-level connectomes that aid the prediction of CU traits. Regions revealed with this method contextualize behavioral impairments in these youth, and this mask of identified regions could improve the prediction of youth higher in CU traits." @default.
• W4377941045 created "2023-05-25" @default.
• W4377941045 creator A5025011447 @default.
• W4377941045 creator A5035546497 @default.
• W4377941045 creator A5056280022 @default.
• W4377941045 creator A5067617770 @default.
• W4377941045 date "2023-09-01" @default.
• W4377941045 modified "2023-10-17" @default.
• W4377941045 title "Efficiency of Heterogenous Functional Connectomes Explains Variance in Callous-Unemotional Traits After Computational Lesioning of Cortical Midline and Salience Regions" @default.
• W4377941045 cites W147502313 @default.
• W4377941045 cites W1555297499 @default.
• W4377941045 cites W196787403 @default.
• W4377941045 cites W1969676322 @default.
• W4377941045 cites W1974764791 @default.
• W4377941045 cites W1983183519 @default.
• W4377941045 cites W1983208069 @default.
• W4377941045 cites W1987777830 @default.
• W4377941045 cites W1994476196 @default.
• W4377941045 cites W1995996823 @default.
• W4377941045 cites W1999830133 @default.
• W4377941045 cites W2000619457 @default.
• W4377941045 cites W2000998192 @default.
• W4377941045 cites W2004285623 @default.
• W4377941045 cites W2006586971 @default.
• W4377941045 cites W2012137634 @default.
• W4377941045 cites W2016945024 @default.
• W4377941045 cites W2017987256 @default.
• W4377941045 cites W2028645759 @default.
• W4377941045 cites W2029435482 @default.
• W4377941045 cites W2033078279 @default.
• W4377941045 cites W2035726104 @default.
• W4377941045 cites W2040975718 @default.
• W4377941045 cites W2041832654 @default.
• W4377941045 cites W2045748377 @default.
• W4377941045 cites W2046370655 @default.
• W4377941045 cites W2058046532 @default.
• W4377941045 cites W2060464767 @default.
• W4377941045 cites W2063404606 @default.
• W4377941045 cites W2065078072 @default.
• W4377941045 cites W2066858195 @default.
• W4377941045 cites W2069936185 @default.
• W4377941045 cites W2079587799 @default.
• W4377941045 cites W2079963397 @default.
• W4377941045 cites W2084764358 @default.
• W4377941045 cites W2085423000 @default.
• W4377941045 cites W2094109313 @default.
• W4377941045 cites W2095293504 @default.
• W4377941045 cites W2100410543 @default.
• W4377941045 cites W2101135654 @default.
• W4377941045 cites W2105337517 @default.
• W4377941045 cites W2105504969 @default.
• W4377941045 cites W2110113299 @default.
• W4377941045 cites W2111353176 @default.
• W4377941045 cites W2112023300 @default.
• W4377941045 cites W2116967320 @default.
• W4377941045 cites W2122405502 @default.
• W4377941045 cites W2123330495 @default.
• W4377941045 cites W2124757386 @default.
• W4377941045 cites W2125752615 @default.
• W4377941045 cites W2125823313 @default.
• W4377941045 cites W2125868297 @default.
• W4377941045 cites W2126667486 @default.
• W4377941045 cites W2131398580 @default.
• W4377941045 cites W2131681506 @default.
• W4377941045 cites W2131743662 @default.
• W4377941045 cites W2132297989 @default.
• W4377941045 cites W2135275085 @default.
• W4377941045 cites W2138905229 @default.
• W4377941045 cites W2142029338 @default.
• W4377941045 cites W2144364601 @default.
• W4377941045 cites W2144427015 @default.
• W4377941045 cites W2146420292 @default.
• W4377941045 cites W2152072180 @default.
• W4377941045 cites W2156537467 @default.
• W4377941045 cites W2156795839 @default.
• W4377941045 cites W2164854290 @default.
• W4377941045 cites W2165103371 @default.
• W4377941045 cites W2166279933 @default.
• W4377941045 cites W2167822639 @default.
• W4377941045 cites W2171266569 @default.
• W4377941045 cites W2212995821 @default.
• W4377941045 cites W2252579899 @default.
• W4377941045 cites W2270364343 @default.
• W4377941045 cites W2278378178 @default.
• W4377941045 cites W2510229627 @default.
• W4377941045 cites W2592693905 @default.
• W4377941045 cites W2748568034 @default.
• W4377941045 cites W2751855746 @default.
• W4377941045 cites W2773180637 @default.
• W4377941045 cites W2788582295 @default.
• W4377941045 cites W2808004150 @default.
• W4377941045 cites W2810281990 @default.
• W4377941045 cites W3042892183 @default.
• W4377941045 cites W3082186841 @default.
• W4377941045 cites W3102500902 @default.
• W4377941045 cites W3115295277 @default.
• W4377941045 cites W3124390662 @default.
• W4377941045 cites W3136570541 @default.

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