Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377942312> ?p ?o ?g. }
- W4377942312 endingPage "1580" @default.
- W4377942312 startingPage "1580" @default.
- W4377942312 abstract "Breast cancer has a high prevalence in the world and creates a substantial socio-economic impact. Polymer micelles used as nano-sized polymer therapeutics have shown great advantages in treating breast cancer. Here, we aim to develop a dual-targeted pH-sensitive hybrid polymer (HPPF) micelles for improving the stability, controlled-release ability and targeting ability of the breast cancer treatment options. The HPPF micelles were constructed using the hyaluronic acid modified polyhistidine (HA-PHis) and folic acid modified Plannick (PF127-FA), which were characterized via 1H NMR. The optimized mixing ratio (HA-PHis:PF127-FA) was 8:2 according to the change of particle size and zeta potential. The stability of HPPF micelles were enhanced with the higher zeta potential and lower critical micelle concentration compared with HA-PHis and PF127-FA. The drug release percents significantly increased from 45% to 90% with the decrease in pH, which illustrated that HPPF micelles were pH-sensitive owing to the protonation of PHis. The cytotoxicity, in vitro cellular uptake and in vivo fluorescence imaging experiments showed that HPPF micelles had the highest targeting ability utilizing FA and HA, compared with HA-PHis and PF127-FA. Thus, this study constructs an innovative nano-scaled drug delivery system, which provides a new strategy for the treatment of breast cancer." @default.
- W4377942312 created "2023-05-25" @default.
- W4377942312 creator A5011862588 @default.
- W4377942312 creator A5014863753 @default.
- W4377942312 creator A5016742496 @default.
- W4377942312 creator A5017890959 @default.
- W4377942312 creator A5029075394 @default.
- W4377942312 creator A5053432362 @default.
- W4377942312 date "2023-05-24" @default.
- W4377942312 modified "2023-10-01" @default.
- W4377942312 title "Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone" @default.
- W4377942312 cites W1559831904 @default.
- W4377942312 cites W1961026612 @default.
- W4377942312 cites W1978965935 @default.
- W4377942312 cites W2060713279 @default.
- W4377942312 cites W2069271683 @default.
- W4377942312 cites W2078415477 @default.
- W4377942312 cites W2089093977 @default.
- W4377942312 cites W2091010508 @default.
- W4377942312 cites W2118844383 @default.
- W4377942312 cites W2152344575 @default.
- W4377942312 cites W2167352353 @default.
- W4377942312 cites W2202116730 @default.
- W4377942312 cites W2749453530 @default.
- W4377942312 cites W2800124727 @default.
- W4377942312 cites W2800217682 @default.
- W4377942312 cites W2802203073 @default.
- W4377942312 cites W2897221262 @default.
- W4377942312 cites W2904989956 @default.
- W4377942312 cites W2921727504 @default.
- W4377942312 cites W2938581582 @default.
- W4377942312 cites W2953426428 @default.
- W4377942312 cites W2954843988 @default.
- W4377942312 cites W2971935259 @default.
- W4377942312 cites W2991627928 @default.
- W4377942312 cites W2991922517 @default.
- W4377942312 cites W3003650800 @default.
- W4377942312 cites W3007042680 @default.
- W4377942312 cites W3090745811 @default.
- W4377942312 cites W3093454800 @default.
- W4377942312 cites W3119005666 @default.
- W4377942312 cites W3134531697 @default.
- W4377942312 cites W3154370106 @default.
- W4377942312 cites W3159489770 @default.
- W4377942312 cites W3185842637 @default.
- W4377942312 cites W3200904887 @default.
- W4377942312 cites W3204714568 @default.
- W4377942312 cites W3208879561 @default.
- W4377942312 cites W4200498664 @default.
- W4377942312 cites W4211259434 @default.
- W4377942312 cites W4220898488 @default.
- W4377942312 cites W4224272066 @default.
- W4377942312 cites W4225093770 @default.
- W4377942312 cites W4281554616 @default.
- W4377942312 cites W4293171277 @default.
- W4377942312 cites W4309177430 @default.
- W4377942312 cites W4310171592 @default.
- W4377942312 doi "https://doi.org/10.3390/pharmaceutics15061580" @default.
- W4377942312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37376029" @default.
- W4377942312 hasPublicationYear "2023" @default.
- W4377942312 type Work @default.
- W4377942312 citedByCount "0" @default.
- W4377942312 crossrefType "journal-article" @default.
- W4377942312 hasAuthorship W4377942312A5011862588 @default.
- W4377942312 hasAuthorship W4377942312A5014863753 @default.
- W4377942312 hasAuthorship W4377942312A5016742496 @default.
- W4377942312 hasAuthorship W4377942312A5017890959 @default.
- W4377942312 hasAuthorship W4377942312A5029075394 @default.
- W4377942312 hasAuthorship W4377942312A5053432362 @default.
- W4377942312 hasBestOaLocation W43779423121 @default.
- W4377942312 hasConcept C105702510 @default.
- W4377942312 hasConcept C11268172 @default.
- W4377942312 hasConcept C121608353 @default.
- W4377942312 hasConcept C126322002 @default.
- W4377942312 hasConcept C13965031 @default.
- W4377942312 hasConcept C147789679 @default.
- W4377942312 hasConcept C150903083 @default.
- W4377942312 hasConcept C155672457 @default.
- W4377942312 hasConcept C171250308 @default.
- W4377942312 hasConcept C178790620 @default.
- W4377942312 hasConcept C184651966 @default.
- W4377942312 hasConcept C185592680 @default.
- W4377942312 hasConcept C187530423 @default.
- W4377942312 hasConcept C192562407 @default.
- W4377942312 hasConcept C207001950 @default.
- W4377942312 hasConcept C2777529286 @default.
- W4377942312 hasConcept C521977710 @default.
- W4377942312 hasConcept C530470458 @default.
- W4377942312 hasConcept C71924100 @default.
- W4377942312 hasConcept C86181022 @default.
- W4377942312 hasConcept C86803240 @default.
- W4377942312 hasConceptScore W4377942312C105702510 @default.
- W4377942312 hasConceptScore W4377942312C11268172 @default.
- W4377942312 hasConceptScore W4377942312C121608353 @default.
- W4377942312 hasConceptScore W4377942312C126322002 @default.
- W4377942312 hasConceptScore W4377942312C13965031 @default.
- W4377942312 hasConceptScore W4377942312C147789679 @default.
- W4377942312 hasConceptScore W4377942312C150903083 @default.