FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377942360> ?p ?o ?g. }

• W4377942360 endingPage "48" @default.
• W4377942360 startingPage "35" @default.
• W4377942360 abstract "The review analyzes the results of scientific research on the role of aquaporins in the pathogenesis of CNS diseases and the possibility of their pharmacological regulation.&#x0D; Aquaporins (AQP) are proteins involved in the transmembrane transport of water and other substances. They form the water channels of cell membranes and are widely represented in various mammalian cells, including the membranes of human brain and spinal cord cells. To date, about 300 types of proteins of the aquaporin family have been discovered, of which 13 (AQP0AQP12) have been identified in human cells. Localization of different types of AQP in CNS structures, their functional activity and involvement in the development of CNS diseases differ. There are mainly three types of AQPs in the central nervous system: AQP1, AQP4 and AQP9. The results of scientific research indicate the most important role of AQP in maintaining water-salt homeostasis and ensuring physiological processes in the central nervous system, and also confirm the role of AQP in the pathogenesis of a number of diseases of the central nervous system (cerebral edema of various genesis, invasion of tumor cells and the formation of peritumorous edema, in the development of autoimmune diseases opticomyelitis, Alzheimers disease). Pharmacological regulation of the functional activity of aquaporins can influence the course of these diseases. Therefore, there is a natural interest in drugs that can change the expression of AQP.&#x0D; Proteins of the aquaporin family provide transmembrane transport of water and play an essential role in the development of pathological conditions of the central nervous system. They can be potential targets for pharmacological effects in a number of diseases of the central nervous system. The search and study of drugs affecting the expression and functional activity of AQP is pathogenetically justified and is a promising direction in the development of pharmacotherapy strategies for cerebral edema, malignant brain tumors and other CNS diseases." @default.
• W4377942360 created "2023-05-25" @default.
• W4377942360 creator A5052619153 @default.
• W4377942360 creator A5058732729 @default.
• W4377942360 creator A5071520315 @default.
• W4377942360 date "2023-05-24" @default.
• W4377942360 modified "2023-09-27" @default.
• W4377942360 title "Prospects of pharmacological regulation of aquaporin function in CNS diseases" @default.
• W4377942360 cites W1964139046 @default.
• W4377942360 cites W1969463227 @default.
• W4377942360 cites W1975938382 @default.
• W4377942360 cites W1984031014 @default.
• W4377942360 cites W1984723140 @default.
• W4377942360 cites W1998578388 @default.
• W4377942360 cites W1999940082 @default.
• W4377942360 cites W2002076163 @default.
• W4377942360 cites W2005215061 @default.
• W4377942360 cites W2011706619 @default.
• W4377942360 cites W2012940535 @default.
• W4377942360 cites W2023443299 @default.
• W4377942360 cites W2027470967 @default.
• W4377942360 cites W2034358524 @default.
• W4377942360 cites W2053445847 @default.
• W4377942360 cites W2060701169 @default.
• W4377942360 cites W2064308026 @default.
• W4377942360 cites W2071808733 @default.
• W4377942360 cites W2072492095 @default.
• W4377942360 cites W2092193387 @default.
• W4377942360 cites W2108469833 @default.
• W4377942360 cites W2116374220 @default.
• W4377942360 cites W2118896462 @default.
• W4377942360 cites W2119168378 @default.
• W4377942360 cites W2129388376 @default.
• W4377942360 cites W2132587742 @default.
• W4377942360 cites W2138812985 @default.
• W4377942360 cites W2150371702 @default.
• W4377942360 cites W2150433176 @default.
• W4377942360 cites W2170263306 @default.
• W4377942360 cites W2171013521 @default.
• W4377942360 cites W2231013635 @default.
• W4377942360 cites W2253116428 @default.
• W4377942360 cites W2280015863 @default.
• W4377942360 cites W2291424342 @default.
• W4377942360 cites W2304132324 @default.
• W4377942360 cites W2356307563 @default.
• W4377942360 cites W2357943322 @default.
• W4377942360 cites W2404049684 @default.
• W4377942360 cites W2472213788 @default.
• W4377942360 cites W2499628104 @default.
• W4377942360 cites W2560761116 @default.
• W4377942360 cites W2592917566 @default.
• W4377942360 cites W2615804670 @default.
• W4377942360 cites W2766411834 @default.
• W4377942360 cites W2769567240 @default.
• W4377942360 cites W2800843922 @default.
• W4377942360 cites W2903837608 @default.
• W4377942360 cites W2907111581 @default.
• W4377942360 cites W2912583212 @default.
• W4377942360 cites W2976131232 @default.
• W4377942360 cites W2991507599 @default.
• W4377942360 cites W2991727208 @default.
• W4377942360 cites W3005623115 @default.
• W4377942360 cites W3006908216 @default.
• W4377942360 cites W3025374083 @default.
• W4377942360 cites W3040158595 @default.
• W4377942360 cites W3173957025 @default.
• W4377942360 cites W3216154527 @default.
• W4377942360 cites W4224087418 @default.
• W4377942360 doi "https://doi.org/10.17816/rcf21135-48" @default.
• W4377942360 hasPublicationYear "2023" @default.
• W4377942360 type Work @default.
• W4377942360 citedByCount "0" @default.
• W4377942360 crossrefType "journal-article" @default.
• W4377942360 hasAuthorship W4377942360A5052619153 @default.
• W4377942360 hasAuthorship W4377942360A5058732729 @default.
• W4377942360 hasAuthorship W4377942360A5071520315 @default.
• W4377942360 hasBestOaLocation W43779423601 @default.
• W4377942360 hasConcept C127413603 @default.
• W4377942360 hasConcept C154280991 @default.
• W4377942360 hasConcept C15755913 @default.
• W4377942360 hasConcept C169760540 @default.
• W4377942360 hasConcept C170493617 @default.
• W4377942360 hasConcept C203014093 @default.
• W4377942360 hasConcept C24530287 @default.
• W4377942360 hasConcept C2780942790 @default.
• W4377942360 hasConcept C2988574769 @default.
• W4377942360 hasConcept C2992163139 @default.
• W4377942360 hasConcept C529278444 @default.
• W4377942360 hasConcept C54355233 @default.
• W4377942360 hasConcept C545706735 @default.
• W4377942360 hasConcept C55493867 @default.
• W4377942360 hasConcept C63645605 @default.
• W4377942360 hasConcept C86803240 @default.
• W4377942360 hasConcept C87717796 @default.
• W4377942360 hasConcept C95444343 @default.
• W4377942360 hasConceptScore W4377942360C127413603 @default.
• W4377942360 hasConceptScore W4377942360C154280991 @default.
• W4377942360 hasConceptScore W4377942360C15755913 @default.

• next