Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377965504> ?p ?o ?g. }
- W4377965504 endingPage "100584" @default.
- W4377965504 startingPage "100584" @default.
- W4377965504 abstract "The N termini of proteins contain information about their biochemical properties and functions. These N termini can be processed by proteases and can undergo other co- or posttranslational modifications. We have developed LATE (LysN Amino Terminal Enrichment), a method that uses selective chemical derivatization of α-amines to isolate the N-terminal peptides, in order to improve N-terminome identification in conjunction with other enrichment strategies. We applied LATE alongside another N-terminomic method to study caspase-3-mediated proteolysis both in vitro and during apoptosis in cells. This has enabled us to identify many unreported caspase-3 cleavages, some of which cannot be identified by other methods. Moreover, we have found direct evidence that neo-N-termini generated by caspase-3 cleavage can be further modified by Nt-acetylation. Some of these neo-Nt-acetylation events occur in the early phase of the apoptotic process and may have a role in translation inhibition. This has provided a comprehensive overview of the caspase-3 degradome and has uncovered previously unrecognized cross talk between posttranslational Nt-acetylation and caspase proteolytic pathways." @default.
- W4377965504 created "2023-05-25" @default.
- W4377965504 creator A5008580234 @default.
- W4377965504 creator A5010086308 @default.
- W4377965504 creator A5021842459 @default.
- W4377965504 creator A5027207824 @default.
- W4377965504 creator A5058332995 @default.
- W4377965504 creator A5058576428 @default.
- W4377965504 date "2023-07-01" @default.
- W4377965504 modified "2023-10-05" @default.
- W4377965504 title "In-Depth Characterization of Apoptosis N-Terminome Reveals a Link Between Caspase-3 Cleavage and Posttranslational N-Terminal Acetylation" @default.
- W4377965504 cites W1797925867 @default.
- W4377965504 cites W1969047557 @default.
- W4377965504 cites W1979139758 @default.
- W4377965504 cites W1979748640 @default.
- W4377965504 cites W1980885930 @default.
- W4377965504 cites W1987045539 @default.
- W4377965504 cites W1988330295 @default.
- W4377965504 cites W1989981367 @default.
- W4377965504 cites W1990119584 @default.
- W4377965504 cites W1995638700 @default.
- W4377965504 cites W2005176113 @default.
- W4377965504 cites W2005488015 @default.
- W4377965504 cites W2008206202 @default.
- W4377965504 cites W2008207297 @default.
- W4377965504 cites W2008708467 @default.
- W4377965504 cites W2009393104 @default.
- W4377965504 cites W2010912389 @default.
- W4377965504 cites W2012604972 @default.
- W4377965504 cites W2025470424 @default.
- W4377965504 cites W2029431569 @default.
- W4377965504 cites W2031318871 @default.
- W4377965504 cites W2037761710 @default.
- W4377965504 cites W2037855331 @default.
- W4377965504 cites W2040385059 @default.
- W4377965504 cites W2041686750 @default.
- W4377965504 cites W2045376151 @default.
- W4377965504 cites W2046347466 @default.
- W4377965504 cites W2051681013 @default.
- W4377965504 cites W2052788415 @default.
- W4377965504 cites W2054486599 @default.
- W4377965504 cites W2055552831 @default.
- W4377965504 cites W2061227815 @default.
- W4377965504 cites W2065518020 @default.
- W4377965504 cites W2069508712 @default.
- W4377965504 cites W2073175998 @default.
- W4377965504 cites W2076255097 @default.
- W4377965504 cites W2083815373 @default.
- W4377965504 cites W2084101023 @default.
- W4377965504 cites W2088569816 @default.
- W4377965504 cites W2089273345 @default.
- W4377965504 cites W2092735199 @default.
- W4377965504 cites W2097245190 @default.
- W4377965504 cites W2111515098 @default.
- W4377965504 cites W2112078820 @default.
- W4377965504 cites W2112335973 @default.
- W4377965504 cites W2115943691 @default.
- W4377965504 cites W2119294728 @default.
- W4377965504 cites W2123850865 @default.
- W4377965504 cites W2126103104 @default.
- W4377965504 cites W2137043026 @default.
- W4377965504 cites W2138498907 @default.
- W4377965504 cites W2139492479 @default.
- W4377965504 cites W2150245222 @default.
- W4377965504 cites W2162428774 @default.
- W4377965504 cites W2164118220 @default.
- W4377965504 cites W2168726708 @default.
- W4377965504 cites W2172242534 @default.
- W4377965504 cites W2281865134 @default.
- W4377965504 cites W2306646692 @default.
- W4377965504 cites W2318380017 @default.
- W4377965504 cites W2324321303 @default.
- W4377965504 cites W2325542921 @default.
- W4377965504 cites W2343251287 @default.
- W4377965504 cites W2412131698 @default.
- W4377965504 cites W2467069958 @default.
- W4377965504 cites W2507340919 @default.
- W4377965504 cites W2558103134 @default.
- W4377965504 cites W2690711300 @default.
- W4377965504 cites W2769158327 @default.
- W4377965504 cites W2783890640 @default.
- W4377965504 cites W2789605661 @default.
- W4377965504 cites W2810225090 @default.
- W4377965504 cites W2883210621 @default.
- W4377965504 cites W2936148319 @default.
- W4377965504 cites W2964656922 @default.
- W4377965504 cites W2966849264 @default.
- W4377965504 cites W2970422942 @default.
- W4377965504 cites W2979783309 @default.
- W4377965504 cites W3027072109 @default.
- W4377965504 cites W3039051118 @default.
- W4377965504 cites W3090203087 @default.
- W4377965504 cites W3097325565 @default.
- W4377965504 cites W3112376646 @default.
- W4377965504 cites W3119115403 @default.
- W4377965504 cites W3200167435 @default.
- W4377965504 cites W3211795435 @default.
- W4377965504 cites W4213437949 @default.