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- W4377966557 abstract "An increase in the click-to-release reaction rate between cleavable trans-cyclooctenes (TCO) and tetrazines would be beneficial for drug delivery applications. In this work, we have developed a short and stereoselective synthesis route towards highly reactive sTCOs that serve as cleavable linkers, affording quantitative tetrazine-triggered payload release. In addition, the fivefold more reactive sTCO exhibited the same in vivo stability as current TCO linkers when used as antibody linkers in circulation in mice." @default.
- W4377966557 created "2023-05-25" @default.
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- W4377966557 date "2023-07-14" @default.
- W4377966557 modified "2023-10-14" @default.
- W4377966557 title "A Concise Synthetic Approach to Highly Reactive Click‐to‐Release <i>Trans</i>‐Cyclooctene Linkers**" @default.
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- W4377966557 doi "https://doi.org/10.1002/chem.202300755" @default.
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