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• W4377966954 abstract "Abstract Venous thromboembolism (VTE) is a common disease, the morbidity and mortality during pregnancy and the puerperium are significantly increased. However, the current understanding of its pathogenesis and pathophysiology is not fully adequate, which limits the choice of therapeutic approaches to some extent. In this study, we speculate that the massive accumulation of ROS in vascular endothelial cells after ischemia and hypoxia activates the NLRP3 inflammasome, which in turn releases a large amount of inflammatory factors that contribute to venous thrombosis. To verify the hypothesis, we established a DVT model in pregnant rats by the stenosis method and an H2O2-induced HUVECs model. The study hypothesis was fully confirmed by HE, IHC, Masson, Western blot, qRT-PCR, IF, ELISA, CCK8, LDH, invasion, migration, scratching, tube formation, TUNEL, JC-1 and flow cytometry experiments. We have reached the following results: 1.NLRP3 inflammasome was activated during the development of DVT (P < 0.0001). 2.MCC950 promoted the lysis, mechanization and recanalization of DVT in pregnant rats by inhibiting the activation of NLRP3 inflammasome (P< 0.05). 3.MCC950 reduced embryo loss and improved pregnancy outcome. 4.MCC950 inhibited NLRP3 inflammasome activation after H2O2-induced injury in HUVECs by enhancing ROS sensitivity (P < 0.05). To sum up, the study provides a new basic theoretical basis and potential therapeutic reference for the prevention and treatment of pregnancy-associated venous thromboembolism (PA-VTE)." @default.
• W4377966954 created "2023-05-25" @default.
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• W4377966954 date "2023-05-24" @default.
• W4377966954 modified "2023-09-28" @default.
• W4377966954 title "Blockage of NLRP3 inflammasome by MCC950 can reverse the effect of pyroptosis in HUVECs and thrombosis of pregnancy rats" @default.
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• W4377966954 doi "https://doi.org/10.21203/rs.3.rs-2935166/v1" @default.
• W4377966954 hasPublicationYear "2023" @default.
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