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- W4377968061 abstract "Abstract The respiratory system is the primary route of infection for many contagious pathogens. Mucociliary clearance of inhaled pathogens is an important innate defense mechanism sustained by the rhythmic movement of epithelial cilia. To counter host defenses, viral pathogens target epithelial cells and cilia. For instance, the influenza virus modulates the expression of WDR93 , a central ciliary apparatus C1d projection component. Lineage-specific prevalence of such host defense genes results in differential susceptibility. Our comparative analysis of ∼500 vertebrate genomes supports the widespread conservation of WDR93 . However, we identified loss of the WDR93 in landfowl, geese, and other phylogenetically-independent bird species. Notably, species with WDR93 loss have concurrently lost another C1d component, CFAP46 , through large segmental deletions. Understanding the consequences of such gene loss may provide insight into their role in host-pathogen interactions and benefit global pathogen surveillance efforts by prioritizing species missing host defense genes and identifying putative zoonotic reservoirs." @default.
- W4377968061 created "2023-05-25" @default.
- W4377968061 creator A5067783851 @default.
- W4377968061 creator A5071563850 @default.
- W4377968061 creator A5092007902 @default.
- W4377968061 date "2023-05-24" @default.
- W4377968061 modified "2023-09-30" @default.
- W4377968061 title "Concurrent loss of ciliary genes<i>WDR93</i>and<i>CFAP46</i>in phylogenetically distant birds" @default.
- W4377968061 cites W137951132 @default.
- W4377968061 cites W1437920260 @default.
- W4377968061 cites W1510752733 @default.
- W4377968061 cites W1874721129 @default.
- W4377968061 cites W1916919897 @default.
- W4377968061 cites W1917173555 @default.
- W4377968061 cites W1964693476 @default.
- W4377968061 cites W1967946604 @default.
- W4377968061 cites W1980906460 @default.
- W4377968061 cites W1981274274 @default.
- W4377968061 cites W1984669065 @default.
- W4377968061 cites W1988668970 @default.
- W4377968061 cites W1999727030 @default.
- W4377968061 cites W2003544664 @default.
- W4377968061 cites W2003630425 @default.
- W4377968061 cites W2004617445 @default.
- W4377968061 cites W2020219792 @default.
- W4377968061 cites W2022551045 @default.
- W4377968061 cites W2033585619 @default.
- W4377968061 cites W2039501111 @default.
- W4377968061 cites W2041928918 @default.
- W4377968061 cites W2043191762 @default.
- W4377968061 cites W2050144075 @default.
- W4377968061 cites W2061921252 @default.
- W4377968061 cites W2062094975 @default.
- W4377968061 cites W2066150004 @default.
- W4377968061 cites W2070312133 @default.
- W4377968061 cites W2074830661 @default.
- W4377968061 cites W2080194840 @default.
- W4377968061 cites W2083000914 @default.
- W4377968061 cites W2086759556 @default.
- W4377968061 cites W2087805108 @default.
- W4377968061 cites W2090604623 @default.
- W4377968061 cites W2102619694 @default.
- W4377968061 cites W2105044345 @default.
- W4377968061 cites W2110335151 @default.
- W4377968061 cites W2117131162 @default.
- W4377968061 cites W2117817828 @default.
- W4377968061 cites W2120294060 @default.
- W4377968061 cites W2122016967 @default.
- W4377968061 cites W2124371255 @default.
- W4377968061 cites W2135168024 @default.
- W4377968061 cites W2135829466 @default.
- W4377968061 cites W2136933352 @default.
- W4377968061 cites W2138178197 @default.
- W4377968061 cites W2145181045 @default.
- W4377968061 cites W2148736553 @default.
- W4377968061 cites W2162095767 @default.
- W4377968061 cites W2167406239 @default.
- W4377968061 cites W2168056473 @default.
- W4377968061 cites W2168281890 @default.
- W4377968061 cites W2169456326 @default.
- W4377968061 cites W2170395380 @default.
- W4377968061 cites W2520903201 @default.
- W4377968061 cites W2532120756 @default.
- W4377968061 cites W2534480974 @default.
- W4377968061 cites W2553774727 @default.
- W4377968061 cites W2586746093 @default.
- W4377968061 cites W2750313261 @default.
- W4377968061 cites W2768565919 @default.
- W4377968061 cites W2802575842 @default.
- W4377968061 cites W2890126170 @default.
- W4377968061 cites W2891617094 @default.
- W4377968061 cites W2910890751 @default.
- W4377968061 cites W2944002703 @default.
- W4377968061 cites W2944334491 @default.
- W4377968061 cites W2945153995 @default.
- W4377968061 cites W2964137721 @default.
- W4377968061 cites W2967529952 @default.
- W4377968061 cites W2981163188 @default.
- W4377968061 cites W2983638901 @default.
- W4377968061 cites W2998276170 @default.
- W4377968061 cites W3011087267 @default.
- W4377968061 cites W3040107810 @default.
- W4377968061 cites W3045270027 @default.
- W4377968061 cites W3115191477 @default.
- W4377968061 cites W3127774081 @default.
- W4377968061 cites W3133587660 @default.
- W4377968061 cites W3137421099 @default.
- W4377968061 cites W3138660075 @default.
- W4377968061 cites W3169046770 @default.
- W4377968061 cites W3192069610 @default.
- W4377968061 cites W3215660188 @default.
- W4377968061 cites W4200536075 @default.
- W4377968061 cites W4221056021 @default.
- W4377968061 cites W4221059947 @default.
- W4377968061 cites W4226149143 @default.
- W4377968061 cites W4280491058 @default.
- W4377968061 cites W4280491917 @default.
- W4377968061 cites W4280547321 @default.
- W4377968061 cites W4303511921 @default.
- W4377968061 cites W4311307047 @default.