Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377970843> ?p ?o ?g. }
- W4377970843 endingPage "2196" @default.
- W4377970843 startingPage "2186" @default.
- W4377970843 abstract "To monitor the levels of mitochondrial DNA G-quadruplexes (mtDNA G4s) in spermatozoa and to explore the possibility using mtDNA G4s as a reliable marker in patients with multiple clinical insemination failures, a novel chemical TPE-mTO probe engineered in our previous work was used on both samples from the mice sperm and from patients with fertilization failure. Expression of valosin-containing protein and the zona-free hamster egg assay were used to evaluate mitophagy and human sperm penetration. RNA-sequencing was used to explore expression changes of key genes affected by mtDNA G4s. Results showed that the probe can track mtDNA G4s in spermatozoa easily and quickly with fewer backgrounds. Significantly increased mtDNA G4s were also found in patients with fertilization failure, using the flow-cytometry-based TPE-mTO probe detection method. A sperm-hamster egg penetration experiment showed that abnormal fertilization caused by increased mtDNA G4s can be effectively restored by a mitophagy inducer. This study provides a novel method for monitoring etiological biomarkers in patients with clinical infertility and treatment for patients with abnormal fertilization caused by mtDNA G4 dysfunction." @default.
- W4377970843 created "2023-05-25" @default.
- W4377970843 creator A5000306963 @default.
- W4377970843 creator A5003642180 @default.
- W4377970843 creator A5010984608 @default.
- W4377970843 creator A5015466702 @default.
- W4377970843 creator A5024900774 @default.
- W4377970843 creator A5032131903 @default.
- W4377970843 creator A5034021177 @default.
- W4377970843 creator A5043050875 @default.
- W4377970843 creator A5045840604 @default.
- W4377970843 creator A5050398532 @default.
- W4377970843 creator A5061992369 @default.
- W4377970843 creator A5066737605 @default.
- W4377970843 creator A5075170876 @default.
- W4377970843 creator A5089724313 @default.
- W4377970843 date "2023-05-24" @default.
- W4377970843 modified "2023-10-17" @default.
- W4377970843 title "Dissecting Sperm Mitochondrial G-Quadruplex Structures Using a Fluorescent Probe Biomarker to Monitor and Regulate Fertilization Capability" @default.
- W4377970843 cites W158295123 @default.
- W4377970843 cites W1887262817 @default.
- W4377970843 cites W1967523984 @default.
- W4377970843 cites W2035667154 @default.
- W4377970843 cites W2045611938 @default.
- W4377970843 cites W2049016912 @default.
- W4377970843 cites W2076805289 @default.
- W4377970843 cites W2079640584 @default.
- W4377970843 cites W2098575129 @default.
- W4377970843 cites W2115688047 @default.
- W4377970843 cites W2126398144 @default.
- W4377970843 cites W2159902645 @default.
- W4377970843 cites W2179438025 @default.
- W4377970843 cites W2235657766 @default.
- W4377970843 cites W2413180549 @default.
- W4377970843 cites W2468882414 @default.
- W4377970843 cites W2516126943 @default.
- W4377970843 cites W2550497802 @default.
- W4377970843 cites W2742977097 @default.
- W4377970843 cites W2752455371 @default.
- W4377970843 cites W2764069214 @default.
- W4377970843 cites W2771691812 @default.
- W4377970843 cites W2790887288 @default.
- W4377970843 cites W2793408994 @default.
- W4377970843 cites W2939757894 @default.
- W4377970843 cites W2942166600 @default.
- W4377970843 cites W2967730711 @default.
- W4377970843 cites W2992920422 @default.
- W4377970843 cites W3001155648 @default.
- W4377970843 cites W3024387562 @default.
- W4377970843 cites W3039855819 @default.
- W4377970843 cites W3128915830 @default.
- W4377970843 cites W3133091493 @default.
- W4377970843 cites W64700927 @default.
- W4377970843 doi "https://doi.org/10.1021/acssensors.3c00068" @default.
- W4377970843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37224082" @default.
- W4377970843 hasPublicationYear "2023" @default.
- W4377970843 type Work @default.
- W4377970843 citedByCount "1" @default.
- W4377970843 countsByYear W43779708432023 @default.
- W4377970843 crossrefType "journal-article" @default.
- W4377970843 hasAuthorship W4377970843A5000306963 @default.
- W4377970843 hasAuthorship W4377970843A5003642180 @default.
- W4377970843 hasAuthorship W4377970843A5010984608 @default.
- W4377970843 hasAuthorship W4377970843A5015466702 @default.
- W4377970843 hasAuthorship W4377970843A5024900774 @default.
- W4377970843 hasAuthorship W4377970843A5032131903 @default.
- W4377970843 hasAuthorship W4377970843A5034021177 @default.
- W4377970843 hasAuthorship W4377970843A5043050875 @default.
- W4377970843 hasAuthorship W4377970843A5045840604 @default.
- W4377970843 hasAuthorship W4377970843A5050398532 @default.
- W4377970843 hasAuthorship W4377970843A5061992369 @default.
- W4377970843 hasAuthorship W4377970843A5066737605 @default.
- W4377970843 hasAuthorship W4377970843A5075170876 @default.
- W4377970843 hasAuthorship W4377970843A5089724313 @default.
- W4377970843 hasConcept C104317684 @default.
- W4377970843 hasConcept C153911025 @default.
- W4377970843 hasConcept C16685009 @default.
- W4377970843 hasConcept C24586158 @default.
- W4377970843 hasConcept C2778575167 @default.
- W4377970843 hasConcept C2781087480 @default.
- W4377970843 hasConcept C54355233 @default.
- W4377970843 hasConcept C71924100 @default.
- W4377970843 hasConcept C86803240 @default.
- W4377970843 hasConcept C88972607 @default.
- W4377970843 hasConcept C95444343 @default.
- W4377970843 hasConceptScore W4377970843C104317684 @default.
- W4377970843 hasConceptScore W4377970843C153911025 @default.
- W4377970843 hasConceptScore W4377970843C16685009 @default.
- W4377970843 hasConceptScore W4377970843C24586158 @default.
- W4377970843 hasConceptScore W4377970843C2778575167 @default.
- W4377970843 hasConceptScore W4377970843C2781087480 @default.
- W4377970843 hasConceptScore W4377970843C54355233 @default.
- W4377970843 hasConceptScore W4377970843C71924100 @default.
- W4377970843 hasConceptScore W4377970843C86803240 @default.
- W4377970843 hasConceptScore W4377970843C88972607 @default.
- W4377970843 hasConceptScore W4377970843C95444343 @default.
- W4377970843 hasFunder F4320321001 @default.
- W4377970843 hasFunder F4320335777 @default.