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• W4377972046 abstract "Intracellular pH plays a crucial role in many cellular processes, and abnormal intracellular pH has been linked to common diseases such as cancer and Alzheimer's. To address this issue, a water-soluble fluorescent pH probe was designed based on the protonation/deprotonation of the 4-methylpiperazin-1-yl group, using dicyanoisophorone as the fluorophore. In the neutral form of the probe, fluorescence is quenched due to charge transfer from the 4-methylpiperazin-1-yl group to the fluorophore upon excitation. Under acidic conditions, protonation of the 4-methylpiperazin-1-yl group inhibits the photoinduced electron transfer process, leading to an increase in fluorescence intensity. Density-functional theory calculations also verified the fluorescence OFF-ON mechanism. The probe exhibits high selectivity, photostability, fast response to pH changes, and low cytotoxicity to cells. Additionally, the probe selectively accumulates in lysosomes, with a high Pearson coefficient (0.95) using LysoTracker Green DND-26 as a reference. Notably, the probe can monitor lysosomal pH changes in living cells and track pH changes stimulated by chloroquine. We anticipate that the probe has potential for diagnosing pH-related diseases." @default.
• W4377972046 created "2023-05-25" @default.
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• W4377972046 date "2023-01-01" @default.
• W4377972046 modified "2023-09-27" @default.
• W4377972046 title "A water-soluble fluorescent pH probe and its application for monitoring lysosomal pH changes in living cells" @default.
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• W4377972046 doi "https://doi.org/10.1039/d3ay00343d" @default.
• W4377972046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37317586" @default.
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