FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377990586> ?p ?o ?g. }

• W4377990586 endingPage "153555" @default.
• W4377990586 startingPage "153555" @default.
• W4377990586 abstract "Cysteamine, a sulfhydryl compound, is an intermediate in the metabolism of coenzyme A to taurine in living organisms. However, the potential side effects of cysteamine such as hepatotoxicity in pediatric patients have been reported in some studies. To evaluate the impact of cysteamine on infants and children, larval zebrafish (a vertebrate model) were exposed to 0.18, 0.36 and 0.54 mM cysteamine from 72 hpf to 144 hpf. Alterations in general and pathological evaluation, biochemical parameters, cell proliferation, lipid metabolism factors, inflammatory factors and Wnt signaling pathway levels were examined. Increased liver area and lipid accumulation were observed in liver morphology, staining and histopathology in a dose-dependent manner with cysteamine exposure. In addition, the experimental cysteamine group exhibited higher alanine aminotransferase, aspartate aminotransferase, total triglyceride and total cholesterol levels than the control group. Meanwhile, the levels of lipogenesis-related factors ascended whereas lipid transport-related factors descended. Oxidative stress indicators such as reactive oxygen species, MDA and SOD were upregulated after cysteamine exposure. Afterwards, transcription assays revealed that biotinidase and Wnt pathway-related genes were upregulated in the exposed group, and inhibition of Wnt signaling partially rescued the abnormal liver development. The current study found that cysteamine-induced hepatotoxicity in larval zebrafish is due to inflammation and abnormal lipid metabolism, which is mediated by biotinidase (a potential pantetheinase isoenzyme) and Wnt signaling. This provides a perspective on the safety of cysteamine administration in children and identifies potential targets for protection against adverse reactions." @default.
• W4377990586 created "2023-05-25" @default.
• W4377990586 creator A5005808129 @default.
• W4377990586 creator A5011506512 @default.
• W4377990586 creator A5014247613 @default.
• W4377990586 creator A5033684035 @default.
• W4377990586 creator A5033720641 @default.
• W4377990586 creator A5046879450 @default.
• W4377990586 creator A5048613300 @default.
• W4377990586 creator A5055902466 @default.
• W4377990586 creator A5056248574 @default.
• W4377990586 creator A5057326412 @default.
• W4377990586 creator A5066716873 @default.
• W4377990586 creator A5073933415 @default.
• W4377990586 creator A5086159965 @default.
• W4377990586 creator A5087324890 @default.
• W4377990586 date "2023-07-01" @default.
• W4377990586 modified "2023-10-07" @default.
• W4377990586 title "Hepatic lipid metabolism disorders and immunotoxicity induced by cysteamine in early developmental stages of zebrafish" @default.
• W4377990586 cites W1121521847 @default.
• W4377990586 cites W1484800552 @default.
• W4377990586 cites W1622799587 @default.
• W4377990586 cites W1976005518 @default.
• W4377990586 cites W1981239255 @default.
• W4377990586 cites W1988743548 @default.
• W4377990586 cites W1990560333 @default.
• W4377990586 cites W2000220313 @default.
• W4377990586 cites W2014640933 @default.
• W4377990586 cites W2026072432 @default.
• W4377990586 cites W2046358376 @default.
• W4377990586 cites W2054768876 @default.
• W4377990586 cites W2080991284 @default.
• W4377990586 cites W2084299658 @default.
• W4377990586 cites W2109044503 @default.
• W4377990586 cites W2111278403 @default.
• W4377990586 cites W2126742055 @default.
• W4377990586 cites W2137592886 @default.
• W4377990586 cites W2160985186 @default.
• W4377990586 cites W2163810943 @default.
• W4377990586 cites W2180781204 @default.
• W4377990586 cites W2330393805 @default.
• W4377990586 cites W2588964480 @default.
• W4377990586 cites W2797499614 @default.
• W4377990586 cites W2990734695 @default.
• W4377990586 cites W3011691697 @default.
• W4377990586 cites W3024480438 @default.
• W4377990586 cites W3036319615 @default.
• W4377990586 cites W3037347913 @default.
• W4377990586 cites W3048280700 @default.
• W4377990586 cites W3126956205 @default.
• W4377990586 cites W3130369152 @default.
• W4377990586 cites W3192786607 @default.
• W4377990586 cites W4282913778 @default.
• W4377990586 cites W4294190217 @default.
• W4377990586 doi "https://doi.org/10.1016/j.tox.2023.153555" @default.
• W4377990586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37236339" @default.
• W4377990586 hasPublicationYear "2023" @default.
• W4377990586 type Work @default.
• W4377990586 citedByCount "0" @default.
• W4377990586 crossrefType "journal-article" @default.
• W4377990586 hasAuthorship W4377990586A5005808129 @default.
• W4377990586 hasAuthorship W4377990586A5011506512 @default.
• W4377990586 hasAuthorship W4377990586A5014247613 @default.
• W4377990586 hasAuthorship W4377990586A5033684035 @default.
• W4377990586 hasAuthorship W4377990586A5033720641 @default.
• W4377990586 hasAuthorship W4377990586A5046879450 @default.
• W4377990586 hasAuthorship W4377990586A5048613300 @default.
• W4377990586 hasAuthorship W4377990586A5055902466 @default.
• W4377990586 hasAuthorship W4377990586A5056248574 @default.
• W4377990586 hasAuthorship W4377990586A5057326412 @default.
• W4377990586 hasAuthorship W4377990586A5066716873 @default.
• W4377990586 hasAuthorship W4377990586A5073933415 @default.
• W4377990586 hasAuthorship W4377990586A5086159965 @default.
• W4377990586 hasAuthorship W4377990586A5087324890 @default.
• W4377990586 hasConcept C104317684 @default.
• W4377990586 hasConcept C126322002 @default.
• W4377990586 hasConcept C134018914 @default.
• W4377990586 hasConcept C137620995 @default.
• W4377990586 hasConcept C185592680 @default.
• W4377990586 hasConcept C2776151105 @default.
• W4377990586 hasConcept C2776175330 @default.
• W4377990586 hasConcept C2776609658 @default.
• W4377990586 hasConcept C2776878037 @default.
• W4377990586 hasConcept C4733338 @default.
• W4377990586 hasConcept C55493867 @default.
• W4377990586 hasConcept C62478195 @default.
• W4377990586 hasConcept C71924100 @default.
• W4377990586 hasConcept C86803240 @default.
• W4377990586 hasConceptScore W4377990586C104317684 @default.
• W4377990586 hasConceptScore W4377990586C126322002 @default.
• W4377990586 hasConceptScore W4377990586C134018914 @default.
• W4377990586 hasConceptScore W4377990586C137620995 @default.
• W4377990586 hasConceptScore W4377990586C185592680 @default.
• W4377990586 hasConceptScore W4377990586C2776151105 @default.
• W4377990586 hasConceptScore W4377990586C2776175330 @default.
• W4377990586 hasConceptScore W4377990586C2776609658 @default.
• W4377990586 hasConceptScore W4377990586C2776878037 @default.
• W4377990586 hasConceptScore W4377990586C4733338 @default.

• next