Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378072238> ?p ?o ?g. }
- W4378072238 endingPage "781" @default.
- W4378072238 startingPage "781" @default.
- W4378072238 abstract "Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt-cocrystal continuum was preferably formed by employing liquid-assisted grinding (LAG) using ethanol (EtOH). Attempts to prepare the coamorphous salt starting from the salt-cocrystal continuum by NG were unsuccessful. Interestingly, through ball milling by NG or LAG, a great diversity of solid forms (PGZ·HCl-FLV 1:1) could be accessed: NG and hexane (coamorphous); ethyl acetate (physical mixture); EtOH (salt-cocrystal continuum); and water (which presents two Tg, indicating immiscibility of the components). An exploration was performed at different drug-to-drug ratios by NG. By differential scanning calorimetry (DSC), the presence of two endothermic events was observed in this screening: incongruous melting point (solidus) and excess of one of the components (liquidus), except in the 1:1 solid form. From these results, eutectic behavior was observed. Through the construction of a binary phase diagram, it was determined that the 1:1 molar ratio gives rise to the formation of the most stable coamorphous composition. Dissolution profile studies of these solid forms were carried out, specifically on pure FLV and the solid forms of PGZ⋅HCl-FLV (1:2; 1:4; and 1:6), together with the coamorphous 1:1 salt. By itself, pure FLV presented the highest Kint (13.6270 ± 0.8127 mg/cm2⋅min). On the other hand, the coamorphous 1:1 showed a very low Kint (0.0220 ± 0.0014 mg/cm2·min), indicating very fast recrystallization by the FLV, which avoids observing a sudden release of this drug in the solution. This same behavior was observed in the eutectic composition 1:2. In the other solid forms, the value of Kint increases along with the %w of FLV. From the mechanochemical point of view, ball milling by NG or LAG became an important synthetic tool since it allows obtaining a great variety of solid forms to explore the solid-state reactivity of the drug-drug solid-form PGZ HCl-FLV." @default.
- W4378072238 created "2023-05-25" @default.
- W4378072238 creator A5013641239 @default.
- W4378072238 creator A5029914596 @default.
- W4378072238 creator A5036081330 @default.
- W4378072238 creator A5040387585 @default.
- W4378072238 creator A5056367688 @default.
- W4378072238 creator A5064708100 @default.
- W4378072238 creator A5067591867 @default.
- W4378072238 creator A5091105109 @default.
- W4378072238 creator A5092013012 @default.
- W4378072238 creator A5092013013 @default.
- W4378072238 date "2023-05-24" @default.
- W4378072238 modified "2023-10-17" @default.
- W4378072238 title "Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug–Drug Systems" @default.
- W4378072238 cites W15764927 @default.
- W4378072238 cites W1603502910 @default.
- W4378072238 cites W1743521370 @default.
- W4378072238 cites W1849031002 @default.
- W4378072238 cites W1965783053 @default.
- W4378072238 cites W1985517207 @default.
- W4378072238 cites W1993600548 @default.
- W4378072238 cites W2011134011 @default.
- W4378072238 cites W2011345174 @default.
- W4378072238 cites W2015203678 @default.
- W4378072238 cites W2015628419 @default.
- W4378072238 cites W2016012908 @default.
- W4378072238 cites W2018855536 @default.
- W4378072238 cites W2024934556 @default.
- W4378072238 cites W2028559919 @default.
- W4378072238 cites W2032402007 @default.
- W4378072238 cites W2038078741 @default.
- W4378072238 cites W2038989038 @default.
- W4378072238 cites W2040518011 @default.
- W4378072238 cites W2047881579 @default.
- W4378072238 cites W2048016595 @default.
- W4378072238 cites W2048335018 @default.
- W4378072238 cites W2057168330 @default.
- W4378072238 cites W2063969541 @default.
- W4378072238 cites W2065782541 @default.
- W4378072238 cites W2066343035 @default.
- W4378072238 cites W2067777829 @default.
- W4378072238 cites W2073613823 @default.
- W4378072238 cites W2077901889 @default.
- W4378072238 cites W2081616039 @default.
- W4378072238 cites W2094274182 @default.
- W4378072238 cites W2119658072 @default.
- W4378072238 cites W2149980194 @default.
- W4378072238 cites W2169796533 @default.
- W4378072238 cites W2170409119 @default.
- W4378072238 cites W2275521990 @default.
- W4378072238 cites W2335434301 @default.
- W4378072238 cites W2528638105 @default.
- W4378072238 cites W2538823927 @default.
- W4378072238 cites W2605822978 @default.
- W4378072238 cites W2608262817 @default.
- W4378072238 cites W2749053350 @default.
- W4378072238 cites W2774981109 @default.
- W4378072238 cites W2788462403 @default.
- W4378072238 cites W2883257600 @default.
- W4378072238 cites W2886138501 @default.
- W4378072238 cites W2890167547 @default.
- W4378072238 cites W2911120881 @default.
- W4378072238 cites W2990034338 @default.
- W4378072238 cites W2996744211 @default.
- W4378072238 cites W2998714878 @default.
- W4378072238 cites W3006606988 @default.
- W4378072238 cites W3029502887 @default.
- W4378072238 cites W3047586688 @default.
- W4378072238 cites W3164942200 @default.
- W4378072238 cites W3213992704 @default.
- W4378072238 cites W4250249232 @default.
- W4378072238 cites W4297907095 @default.
- W4378072238 cites W4309768149 @default.
- W4378072238 doi "https://doi.org/10.3390/ph16060781" @default.
- W4378072238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37375729" @default.
- W4378072238 hasPublicationYear "2023" @default.
- W4378072238 type Work @default.
- W4378072238 citedByCount "0" @default.
- W4378072238 crossrefType "journal-article" @default.
- W4378072238 hasAuthorship W4378072238A5013641239 @default.
- W4378072238 hasAuthorship W4378072238A5029914596 @default.
- W4378072238 hasAuthorship W4378072238A5036081330 @default.
- W4378072238 hasAuthorship W4378072238A5040387585 @default.
- W4378072238 hasAuthorship W4378072238A5056367688 @default.
- W4378072238 hasAuthorship W4378072238A5064708100 @default.
- W4378072238 hasAuthorship W4378072238A5067591867 @default.
- W4378072238 hasAuthorship W4378072238A5091105109 @default.
- W4378072238 hasAuthorship W4378072238A5092013012 @default.
- W4378072238 hasAuthorship W4378072238A5092013013 @default.
- W4378072238 hasBestOaLocation W43780722381 @default.
- W4378072238 hasConcept C121332964 @default.
- W4378072238 hasConcept C132186339 @default.
- W4378072238 hasConcept C13530604 @default.
- W4378072238 hasConcept C13965031 @default.
- W4378072238 hasConcept C145653223 @default.
- W4378072238 hasConcept C178790620 @default.
- W4378072238 hasConcept C185592680 @default.