Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378082562> ?p ?o ?g. }
- W4378082562 abstract "Dietary astaxanthin exists predominantly as the all-E-isomer; however, certain amounts of the Z-isomers are universally present in the skin, whose roles remain largely unknown. The aim of this study was to investigate the effects of the astaxanthin E/Z-isomer ratio on skin-related physicochemical properties and biological activities using human dermal fibroblasts and B16 mouse melanoma cells. We revealed that astaxanthin enriched in Z-isomers (total Z-isomer ratio = 86.6%) exhibited greater UV-light-shielding ability and skin antiaging and skin-whitening activities, such as anti-elastase and anti-melanin formation activities, than the all-E-isomer-rich astaxanthin (total Z-isomer ratio = 3.3%). On the other hand, the all-E-isomer was superior to the Z-isomers in singlet oxygen scavenging/quenching activity, and the Z-isomers inhibited type I collagen release into the culture medium in a dose-dependent manner. Our findings help clarify the roles of astaxanthin Z-isomers in the skin and would help in the development of novel skin health-promoting food ingredients." @default.
- W4378082562 created "2023-05-25" @default.
- W4378082562 creator A5008682845 @default.
- W4378082562 creator A5072494563 @default.
- W4378082562 date "2023-05-23" @default.
- W4378082562 modified "2023-10-09" @default.
- W4378082562 title "<i>In Vitro</i> Evaluation of Skin-Related Physicochemical Properties and Biological Activities of Astaxanthin Isomers" @default.
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- W4378082562 doi "https://doi.org/10.1021/acsomega.2c08173" @default.
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- W4378082562 hasPublicationYear "2023" @default.
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