Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378085118> ?p ?o ?g. }
- W4378085118 endingPage "2878" @default.
- W4378085118 startingPage "2878" @default.
- W4378085118 abstract "Exosomes are extracellular vesicles (EVs) of nanometric size studied for their role in tumor pathogenesis and progression and as a new source of tumor biomarkers. The clinical studies have provided encouraging but probably unexpected results, including the exosome plasmatic levels’ clinical relevance and well-known biomarkers’ overexpression on the circulating EVs. The technical approach to obtaining EVs includes methods to physically purify EVs and characterize EVs, such as Nanosight Tracking Analysis (NTA), immunocapture-based ELISA, and nano-scale flow cytometry. Based on the above approaches, some clinical investigations have been performed on patients with different tumors, providing exciting and promising results. Here we emphasize data showing that exosome plasmatic levels are consistently higher in tumor patients than in controls and that plasmatic exosomes express well-known tumor markers (e.g., PSA and CEA), proteins with enzymatic activity, and nucleic acids. However, we also know that tumor microenvironment acidity is a key factor in influencing both the amount and the characteristics of the exosome released by tumor cells. In fact, acidity significantly increases exosome release by tumor cells, which correlates with the number of exosomes that circulate through the body of a tumor patient." @default.
- W4378085118 created "2023-05-25" @default.
- W4378085118 creator A5004981000 @default.
- W4378085118 creator A5008077481 @default.
- W4378085118 creator A5011696849 @default.
- W4378085118 creator A5057745379 @default.
- W4378085118 creator A5059306683 @default.
- W4378085118 date "2023-05-23" @default.
- W4378085118 modified "2023-09-27" @default.
- W4378085118 title "The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients" @default.
- W4378085118 cites W117576088 @default.
- W4378085118 cites W1500925570 @default.
- W4378085118 cites W1525657614 @default.
- W4378085118 cites W1528198209 @default.
- W4378085118 cites W1562385120 @default.
- W4378085118 cites W1583187865 @default.
- W4378085118 cites W1787884960 @default.
- W4378085118 cites W1857430040 @default.
- W4378085118 cites W1873432586 @default.
- W4378085118 cites W1915536483 @default.
- W4378085118 cites W1937665132 @default.
- W4378085118 cites W1970420774 @default.
- W4378085118 cites W1973649102 @default.
- W4378085118 cites W1974954833 @default.
- W4378085118 cites W1982436397 @default.
- W4378085118 cites W1992970284 @default.
- W4378085118 cites W1995405710 @default.
- W4378085118 cites W1998802762 @default.
- W4378085118 cites W2000911934 @default.
- W4378085118 cites W2017669919 @default.
- W4378085118 cites W2024206172 @default.
- W4378085118 cites W2034774921 @default.
- W4378085118 cites W2035844407 @default.
- W4378085118 cites W2040138014 @default.
- W4378085118 cites W2050442471 @default.
- W4378085118 cites W2054077259 @default.
- W4378085118 cites W2055313665 @default.
- W4378085118 cites W2066234893 @default.
- W4378085118 cites W2081371902 @default.
- W4378085118 cites W2082289995 @default.
- W4378085118 cites W2084271408 @default.
- W4378085118 cites W2098487511 @default.
- W4378085118 cites W2104397257 @default.
- W4378085118 cites W2108375854 @default.
- W4378085118 cites W2116513340 @default.
- W4378085118 cites W2121354606 @default.
- W4378085118 cites W2128384671 @default.
- W4378085118 cites W2134921841 @default.
- W4378085118 cites W2139966272 @default.
- W4378085118 cites W2141819495 @default.
- W4378085118 cites W2142598717 @default.
- W4378085118 cites W2155566820 @default.
- W4378085118 cites W2160436654 @default.
- W4378085118 cites W2162166420 @default.
- W4378085118 cites W2166166580 @default.
- W4378085118 cites W2169491358 @default.
- W4378085118 cites W2170852633 @default.
- W4378085118 cites W2176301470 @default.
- W4378085118 cites W2180101659 @default.
- W4378085118 cites W2202689921 @default.
- W4378085118 cites W2207291742 @default.
- W4378085118 cites W2213848118 @default.
- W4378085118 cites W2224829538 @default.
- W4378085118 cites W2280121081 @default.
- W4378085118 cites W2301624354 @default.
- W4378085118 cites W2319374670 @default.
- W4378085118 cites W2345807548 @default.
- W4378085118 cites W2396935220 @default.
- W4378085118 cites W2465054563 @default.
- W4378085118 cites W2509815162 @default.
- W4378085118 cites W2510498567 @default.
- W4378085118 cites W2514934726 @default.
- W4378085118 cites W2519218117 @default.
- W4378085118 cites W2532556840 @default.
- W4378085118 cites W2536901971 @default.
- W4378085118 cites W2573522251 @default.
- W4378085118 cites W2574456047 @default.
- W4378085118 cites W2589546201 @default.
- W4378085118 cites W2591074784 @default.
- W4378085118 cites W2593629244 @default.
- W4378085118 cites W2596133050 @default.
- W4378085118 cites W2604622315 @default.
- W4378085118 cites W2605003516 @default.
- W4378085118 cites W2612774616 @default.
- W4378085118 cites W2617507069 @default.
- W4378085118 cites W2728114048 @default.
- W4378085118 cites W2736982071 @default.
- W4378085118 cites W2748440594 @default.
- W4378085118 cites W2768006919 @default.
- W4378085118 cites W2769413428 @default.
- W4378085118 cites W2771541888 @default.
- W4378085118 cites W2779328694 @default.
- W4378085118 cites W2781579322 @default.
- W4378085118 cites W2790514726 @default.
- W4378085118 cites W2795902755 @default.
- W4378085118 cites W2796318327 @default.
- W4378085118 cites W2802476790 @default.
- W4378085118 cites W2802764635 @default.