FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378172316> ?p ?o ?g. }

• W4378172316 abstract "Abstract Whole‐genome sequencing (WGS) has been widely used for the genomic characterization and the phylogenesis of mpox virus (MPXV) 2022 multi‐country outbreak. To date, no evidence has been reported on intra‐host evolution within samples collected over time from a single patient with long‐term infection. Fifty‐one samples were collected from five patients at different time points post‐symptom onset. All samples were confirmed as MPXV DNA positive, amplified by a multiplexed PCR amplicon, and sequenced by WGS. Complete MPXV genomes were assembled by reference mapping and then aligned to perform phylogenetic and hierarchical clustering analysis. Large intra‐host variability was observed among the MPXV genomes sequenced from samples of two immunocompromised with advanced HIV‐1 infection patients with prolonged MPXV shedding. Overall, 20 nucleotide mutations were identified in the 32 genomes from HIV patients, differently distributed in samples collected from different tissues and at different time points. No sequence compartmentalization nor variation was observed in the three patients with rapid viral clearance. MPXV exhibits adaptation to changing environments within the infected host and consequently demonstrates tissue compartmentalization. Further studies are needed to elucidate the role of this adaptation in forming a pool of genetic variability and contributing to viral persistence and its clinical implications." @default.
• W4378172316 created "2023-05-26" @default.
• W4378172316 creator A5000211897 @default.
• W4378172316 creator A5003231872 @default.
• W4378172316 creator A5008526849 @default.
• W4378172316 creator A5014256431 @default.
• W4378172316 creator A5021388726 @default.
• W4378172316 creator A5022022268 @default.
• W4378172316 creator A5025617615 @default.
• W4378172316 creator A5032359240 @default.
• W4378172316 creator A5036744082 @default.
• W4378172316 creator A5047826305 @default.
• W4378172316 creator A5050474520 @default.
• W4378172316 creator A5054248166 @default.
• W4378172316 creator A5058227063 @default.
• W4378172316 creator A5071069252 @default.
• W4378172316 creator A5071671768 @default.
• W4378172316 creator A5075693717 @default.
• W4378172316 creator A5076739427 @default.
• W4378172316 creator A5076900526 @default.
• W4378172316 creator A5078446175 @default.
• W4378172316 creator A5090927599 @default.
• W4378172316 date "2023-05-01" @default.
• W4378172316 modified "2023-10-05" @default.
• W4378172316 title "Temporal intra‐host variability of mpox virus genomes in multiple body tissues" @default.
• W4378172316 cites W2006856155 @default.
• W4378172316 cites W2011301426 @default.
• W4378172316 cites W2096519307 @default.
• W4378172316 cites W2103441770 @default.
• W4378172316 cites W2108234281 @default.
• W4378172316 cites W2129386720 @default.
• W4378172316 cites W2971382621 @default.
• W4378172316 cites W4281666791 @default.
• W4378172316 cites W4281754723 @default.
• W4378172316 cites W4283643760 @default.
• W4378172316 cites W4286383196 @default.
• W4378172316 cites W4288687355 @default.
• W4378172316 cites W4288753036 @default.
• W4378172316 cites W4293368031 @default.
• W4378172316 cites W4295088296 @default.
• W4378172316 cites W4306670860 @default.
• W4378172316 cites W4308029398 @default.
• W4378172316 cites W4308297194 @default.
• W4378172316 cites W4308374349 @default.
• W4378172316 cites W4308464401 @default.
• W4378172316 cites W4317870054 @default.
• W4378172316 cites W4318263104 @default.
• W4378172316 cites W4319301374 @default.
• W4378172316 cites W4321438623 @default.
• W4378172316 cites W4321438780 @default.
• W4378172316 doi "https://doi.org/10.1002/jmv.28791" @default.
• W4378172316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37226579" @default.
• W4378172316 hasPublicationYear "2023" @default.
• W4378172316 type Work @default.
• W4378172316 citedByCount "3" @default.
• W4378172316 countsByYear W43781723162023 @default.
• W4378172316 crossrefType "journal-article" @default.
• W4378172316 hasAuthorship W4378172316A5000211897 @default.
• W4378172316 hasAuthorship W4378172316A5003231872 @default.
• W4378172316 hasAuthorship W4378172316A5008526849 @default.
• W4378172316 hasAuthorship W4378172316A5014256431 @default.
• W4378172316 hasAuthorship W4378172316A5021388726 @default.
• W4378172316 hasAuthorship W4378172316A5022022268 @default.
• W4378172316 hasAuthorship W4378172316A5025617615 @default.
• W4378172316 hasAuthorship W4378172316A5032359240 @default.
• W4378172316 hasAuthorship W4378172316A5036744082 @default.
• W4378172316 hasAuthorship W4378172316A5047826305 @default.
• W4378172316 hasAuthorship W4378172316A5050474520 @default.
• W4378172316 hasAuthorship W4378172316A5054248166 @default.
• W4378172316 hasAuthorship W4378172316A5058227063 @default.
• W4378172316 hasAuthorship W4378172316A5071069252 @default.
• W4378172316 hasAuthorship W4378172316A5071671768 @default.
• W4378172316 hasAuthorship W4378172316A5075693717 @default.
• W4378172316 hasAuthorship W4378172316A5076739427 @default.
• W4378172316 hasAuthorship W4378172316A5076900526 @default.
• W4378172316 hasAuthorship W4378172316A5078446175 @default.
• W4378172316 hasAuthorship W4378172316A5090927599 @default.
• W4378172316 hasBestOaLocation W43781723161 @default.
• W4378172316 hasConcept C104317684 @default.
• W4378172316 hasConcept C126831891 @default.
• W4378172316 hasConcept C139807058 @default.
• W4378172316 hasConcept C141231307 @default.
• W4378172316 hasConcept C159047783 @default.
• W4378172316 hasConcept C169760540 @default.
• W4378172316 hasConcept C193252679 @default.
• W4378172316 hasConcept C24432333 @default.
• W4378172316 hasConcept C2522874641 @default.
• W4378172316 hasConcept C2776914050 @default.
• W4378172316 hasConcept C49105822 @default.
• W4378172316 hasConcept C54355233 @default.
• W4378172316 hasConcept C8185291 @default.
• W4378172316 hasConcept C86803240 @default.
• W4378172316 hasConceptScore W4378172316C104317684 @default.
• W4378172316 hasConceptScore W4378172316C126831891 @default.
• W4378172316 hasConceptScore W4378172316C139807058 @default.
• W4378172316 hasConceptScore W4378172316C141231307 @default.
• W4378172316 hasConceptScore W4378172316C159047783 @default.
• W4378172316 hasConceptScore W4378172316C169760540 @default.
• W4378172316 hasConceptScore W4378172316C193252679 @default.
• W4378172316 hasConceptScore W4378172316C24432333 @default.

• next