Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378172852> ?p ?o ?g. }
- W4378172852 endingPage "535" @default.
- W4378172852 startingPage "526" @default.
- W4378172852 abstract "Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among women wordlwide. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment strategies are needed. In this study, we investigated the anti-cancer effect of synthetic homoisoflavane derivatives of cremastranone on breast cancer cells. Homoisoflavane derivatives, SH-17059 and SH-19021, reduced cell proliferation through G2/M cell cycle arrest and induced caspase-independent cell death. These compounds increased heme oxygenase-1 (HO-1) and 5-aminolevulinic acid synthase 1 (ALAS1), suggesting downregulation of heme. They also induced reactive oxygen species (ROS) generation and lipid peroxidation. Furthermore, they reduced expression of glutathione peroxidase 4 (GPX4). Therefore, we suggest that the SH-17059 and SH-19021 induced the caspase-independent cell death through the accumulation of iron from heme degradation, and the ferroptosis might be one of the potential candidates for caspase-independent cell death." @default.
- W4378172852 created "2023-05-26" @default.
- W4378172852 creator A5015046408 @default.
- W4378172852 creator A5022124273 @default.
- W4378172852 creator A5037681035 @default.
- W4378172852 creator A5038901049 @default.
- W4378172852 creator A5039780289 @default.
- W4378172852 creator A5043191941 @default.
- W4378172852 creator A5076224573 @default.
- W4378172852 creator A5084439467 @default.
- W4378172852 creator A5087927133 @default.
- W4378172852 date "2023-05-25" @default.
- W4378172852 modified "2023-10-17" @default.
- W4378172852 title "Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death" @default.
- W4378172852 cites W1536451770 @default.
- W4378172852 cites W1890655587 @default.
- W4378172852 cites W1940692702 @default.
- W4378172852 cites W1976920897 @default.
- W4378172852 cites W1997183854 @default.
- W4378172852 cites W1998553320 @default.
- W4378172852 cites W2006754144 @default.
- W4378172852 cites W2008209363 @default.
- W4378172852 cites W2012646526 @default.
- W4378172852 cites W2015145065 @default.
- W4378172852 cites W2021505095 @default.
- W4378172852 cites W2023332062 @default.
- W4378172852 cites W2035929222 @default.
- W4378172852 cites W2044702943 @default.
- W4378172852 cites W2064395042 @default.
- W4378172852 cites W2074305443 @default.
- W4378172852 cites W2079145002 @default.
- W4378172852 cites W2092824210 @default.
- W4378172852 cites W2094190961 @default.
- W4378172852 cites W2097255042 @default.
- W4378172852 cites W2098775844 @default.
- W4378172852 cites W2100299115 @default.
- W4378172852 cites W2133105825 @default.
- W4378172852 cites W2134076885 @default.
- W4378172852 cites W2139663727 @default.
- W4378172852 cites W2143308131 @default.
- W4378172852 cites W2145757445 @default.
- W4378172852 cites W2151098840 @default.
- W4378172852 cites W2214273798 @default.
- W4378172852 cites W2259802687 @default.
- W4378172852 cites W2334700441 @default.
- W4378172852 cites W2430555277 @default.
- W4378172852 cites W2470703818 @default.
- W4378172852 cites W2604188130 @default.
- W4378172852 cites W2788640168 @default.
- W4378172852 cites W2793972506 @default.
- W4378172852 cites W2901573161 @default.
- W4378172852 cites W2905675459 @default.
- W4378172852 cites W2912993657 @default.
- W4378172852 cites W2981795130 @default.
- W4378172852 cites W3113059059 @default.
- W4378172852 cites W3128646645 @default.
- W4378172852 cites W3140467300 @default.
- W4378172852 cites W3159001465 @default.
- W4378172852 cites W3183486118 @default.
- W4378172852 cites W3195390993 @default.
- W4378172852 cites W3198894769 @default.
- W4378172852 cites W329007366 @default.
- W4378172852 cites W4211027571 @default.
- W4378172852 cites W4252145143 @default.
- W4378172852 cites W4290741995 @default.
- W4378172852 cites W77625167 @default.
- W4378172852 doi "https://doi.org/10.4062/biomolther.2023.057" @default.
- W4378172852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37226044" @default.
- W4378172852 hasPublicationYear "2023" @default.
- W4378172852 type Work @default.
- W4378172852 citedByCount "0" @default.
- W4378172852 crossrefType "journal-article" @default.
- W4378172852 hasAuthorship W4378172852A5015046408 @default.
- W4378172852 hasAuthorship W4378172852A5022124273 @default.
- W4378172852 hasAuthorship W4378172852A5037681035 @default.
- W4378172852 hasAuthorship W4378172852A5038901049 @default.
- W4378172852 hasAuthorship W4378172852A5039780289 @default.
- W4378172852 hasAuthorship W4378172852A5043191941 @default.
- W4378172852 hasAuthorship W4378172852A5076224573 @default.
- W4378172852 hasAuthorship W4378172852A5084439467 @default.
- W4378172852 hasAuthorship W4378172852A5087927133 @default.
- W4378172852 hasBestOaLocation W43781728521 @default.
- W4378172852 hasConcept C104317684 @default.
- W4378172852 hasConcept C105696609 @default.
- W4378172852 hasConcept C121608353 @default.
- W4378172852 hasConcept C126322002 @default.
- W4378172852 hasConcept C127561419 @default.
- W4378172852 hasConcept C158086472 @default.
- W4378172852 hasConcept C181199279 @default.
- W4378172852 hasConcept C185592680 @default.
- W4378172852 hasConcept C190283241 @default.
- W4378172852 hasConcept C2776217839 @default.
- W4378172852 hasConcept C2778760513 @default.
- W4378172852 hasConcept C2779219270 @default.
- W4378172852 hasConcept C2780829032 @default.
- W4378172852 hasConcept C29537977 @default.
- W4378172852 hasConcept C31573885 @default.
- W4378172852 hasConcept C48349386 @default.