FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378173183> ?p ?o ?g. }

• W4378173183 endingPage "24" @default.
• W4378173183 startingPage "24" @default.
• W4378173183 abstract "This study purposed to depict the transcriptional changes associated with autoimmune uveitis (AU) pathogenesis and identify potential therapeutic targets of this disease.An experimental AU (EAU) model was established with retina antigen and adjuvants. An EAU control group was established with adjuvant only to eliminate nonspecific effects. We conducted single-cell RNA sequencing (scRNA-seq) on cervical draining lymph node cells of EAU, EAU control, and normal mice to identify the EAU-associated transcriptional changes and the potential pathogenic molecules. Subsequent flow cytometry, adoptive transfer experiment, scRNA-seq analysis of human uveitis, and proliferation assessment were conducted to verify the function of the interested molecule in uveitis.The scRNA-seq data suggested that hypoxia-inducible factor 1 alpha (Hif1α) may participate in EAU pathogenesis via regulating T helper (Th)-17, Th1, and regulatory T cells. Hif1α inhibition alleviated EAU symptoms and regulated Th17, Th1, and regulatory T cell proportions. CD4+ T cells with repressed Hif1α expression failed to transfer EAU to naïve mice. In Vogt-Koyanagi-Harada disease, which is a human uveitis, Hif1α was also increased in CD4+ T cells and regulated their proliferation.The results indicate that Hif1α may participate in AU pathogenesis and are, thus, a potential therapeutic target." @default.
• W4378173183 created "2023-05-26" @default.
• W4378173183 creator A5017563434 @default.
• W4378173183 creator A5030637204 @default.
• W4378173183 creator A5039416937 @default.
• W4378173183 creator A5042076633 @default.
• W4378173183 creator A5050459636 @default.
• W4378173183 creator A5065274932 @default.
• W4378173183 creator A5066471162 @default.
• W4378173183 date "2023-05-25" @default.
• W4378173183 modified "2023-09-30" @default.
• W4378173183 title "Identification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis" @default.
• W4378173183 cites W1494340582 @default.
• W4378173183 cites W1597985804 @default.
• W4378173183 cites W197305849 @default.
• W4378173183 cites W1979841486 @default.
• W4378173183 cites W1991860504 @default.
• W4378173183 cites W1995112525 @default.
• W4378173183 cites W2008946188 @default.
• W4378173183 cites W2011810742 @default.
• W4378173183 cites W2023491212 @default.
• W4378173183 cites W2057477434 @default.
• W4378173183 cites W2057847545 @default.
• W4378173183 cites W2103912979 @default.
• W4378173183 cites W2104040734 @default.
• W4378173183 cites W2111930414 @default.
• W4378173183 cites W21185290 @default.
• W4378173183 cites W2131255625 @default.
• W4378173183 cites W2133072156 @default.
• W4378173183 cites W2134053452 @default.
• W4378173183 cites W2158157016 @default.
• W4378173183 cites W2162873738 @default.
• W4378173183 cites W2167104992 @default.
• W4378173183 cites W2336353704 @default.
• W4378173183 cites W2510362766 @default.
• W4378173183 cites W2520252358 @default.
• W4378173183 cites W2537623931 @default.
• W4378173183 cites W2555020059 @default.
• W4378173183 cites W2578062412 @default.
• W4378173183 cites W2611953884 @default.
• W4378173183 cites W2616922646 @default.
• W4378173183 cites W2734872128 @default.
• W4378173183 cites W2756870797 @default.
• W4378173183 cites W2757989747 @default.
• W4378173183 cites W2767508303 @default.
• W4378173183 cites W2791371888 @default.
• W4378173183 cites W2792515464 @default.
• W4378173183 cites W2805568893 @default.
• W4378173183 cites W2809070489 @default.
• W4378173183 cites W28232587 @default.
• W4378173183 cites W2837200535 @default.
• W4378173183 cites W2886347923 @default.
• W4378173183 cites W2895957287 @default.
• W4378173183 cites W2896709929 @default.
• W4378173183 cites W2908438882 @default.
• W4378173183 cites W2909631583 @default.
• W4378173183 cites W2913221496 @default.
• W4378173183 cites W2928665623 @default.
• W4378173183 cites W2939532730 @default.
• W4378173183 cites W2979979535 @default.
• W4378173183 cites W2980559218 @default.
• W4378173183 cites W2983232980 @default.
• W4378173183 cites W2984472267 @default.
• W4378173183 cites W2984611311 @default.
• W4378173183 cites W2989887727 @default.
• W4378173183 cites W2998964414 @default.
• W4378173183 cites W3005706188 @default.
• W4378173183 cites W3024167968 @default.
• W4378173183 cites W3025403854 @default.
• W4378173183 cites W3027314404 @default.
• W4378173183 cites W3046171830 @default.
• W4378173183 cites W3069345335 @default.
• W4378173183 cites W3084404519 @default.
• W4378173183 cites W3091872297 @default.
• W4378173183 cites W3097024925 @default.
• W4378173183 cites W3116723552 @default.
• W4378173183 cites W3120797083 @default.
• W4378173183 cites W3126421096 @default.
• W4378173183 cites W3127808218 @default.
• W4378173183 cites W3135420732 @default.
• W4378173183 cites W3138003106 @default.
• W4378173183 cites W3145278406 @default.
• W4378173183 cites W3160138406 @default.
• W4378173183 cites W3164315209 @default.
• W4378173183 cites W3185439356 @default.
• W4378173183 cites W3197022394 @default.
• W4378173183 cites W3198668715 @default.
• W4378173183 cites W3199734049 @default.
• W4378173183 cites W3215195814 @default.
• W4378173183 cites W4213030341 @default.
• W4378173183 cites W4221078226 @default.
• W4378173183 cites W4233745042 @default.
• W4378173183 cites W4245963222 @default.
• W4378173183 cites W4248230068 @default.
• W4378173183 cites W4248919950 @default.
• W4378173183 cites W4251783876 @default.
• W4378173183 cites W4252357889 @default.
• W4378173183 cites W4282568708 @default.

• next