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• W4378189969 endingPage "114872" @default.
• W4378189969 startingPage "114872" @default.
• W4378189969 abstract "Oligonucleotide-based therapeutics have attracted attention as an emerging modality that includes the modulation of genes and their binding proteins related to diseases, allowing us to take action on previously undruggable targets. Since the late 2010s, the number of oligonucleotide medicines approved for clinical uses has dramatically increased. Various chemistry-based technologies have been developed to improve the therapeutic properties of oligonucleotides, such as chemical modification, conjugation, and nanoparticle formation, which can increase nuclease resistance, enhance affinity and selectivity to target sites, suppress off-target effects, and improve pharmacokinetic properties. Similar strategies employing modified nucleobases and lipid nanoparticles have been used for developing coronavirus disease 2019 mRNA vaccines. In this review, we provide an overview of the development of chemistry-based technologies aimed at using nucleic acids for developing therapeutics over the past several decades, with a specific emphasis on the structural design and functionality of chemical modification strategies." @default.
• W4378189969 created "2023-05-26" @default.
• W4378189969 creator A5028043688 @default.
• W4378189969 creator A5035791716 @default.
• W4378189969 creator A5060329383 @default.
• W4378189969 creator A5071804665 @default.
• W4378189969 date "2023-08-01" @default.
• W4378189969 modified "2023-10-18" @default.
• W4378189969 title "Development of nucleic acid medicines based on chemical technology" @default.
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