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- W4378193705 abstract "Human pluripotent stem cells (hPSCs) have the potential to become the source of materials for cell-based therapy. The similarity of hPSCs with the capability of human embryonic stem cells (hESCs) to self-renew while retaining their ability to differentiate into all cell types in the human body attracts scientists to think about replaceable options to avoid the ethical issue in using hESCs. According to this direction, reprograming normal cells into a pluripotent state has gathered enormous interest during the last 15 years since the Yamanaka group induced pluripotent stem cells from normal fibroblasts. In the process transduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, were demonstrated effective on the reprograming. Later, many techniques of reprogramming normal cells have been established. One of them is the generation of human iPSCs from mononuclear cells (PBMCs) that are separated from peripheral blood by the infection of Sendai virus designed to express the four factors. The reprogramming process should be paid more attention to expect the expansion of the hPSCs availability of clinical and/or practical use. Here we will show the generation of hPSCs from peripheral blood separated from healthy donors. Separation of monocytes and reprogramming will be shown step by step through the process from taking blood samples to observation of hPSCs colonies on feeder cells." @default.
- W4378193705 created "2023-05-26" @default.
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- W4378193705 date "2023-01-01" @default.
- W4378193705 modified "2023-09-26" @default.
- W4378193705 title "Reprogramming of Normal Cells into Human Pluripotent Stem Cells" @default.
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- W4378193705 doi "https://doi.org/10.1007/978-981-99-1331-2_4" @default.
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