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- W4378193775 abstract "In response to a variety of cytokines, vascular endothelial cells proliferate and develop new tube structures from pre-existing blood vessels in quite an orderly manner during normal angiogenesis. However, abnormal angiogenesis contributes to the vast majority of diseases including cancer. Tumor angiogenesis plays a critical role in tumor development, progression, and metastasis. Many reports evaluated that cancer stem cells are responsible for the secretion of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). Also, CSCs were reported to have the potential to differentiate into vascular endothelial cells developing neo-vasculature structures. This chapter offers an overview of the role of CSCs in tumor angiogenesis assessed on chick chorioallantoic membrane (CAM). Furthermore, we show the detailed technique to design the model of CSC-based tumor angiogenesis and propose the possible application to target anti-angiogenesis. This evaluation employing CSCs should help develop more effective anti-angiogenic therapies in the future." @default.
- W4378193775 created "2023-05-26" @default.
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- W4378193775 date "2023-01-01" @default.
- W4378193775 modified "2023-09-26" @default.
- W4378193775 title "Tumor Angiogenesis by Cancer Stem Cells In Vivo" @default.
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- W4378193775 doi "https://doi.org/10.1007/978-981-99-1331-2_13" @default.
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