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- W4378194013 abstract "In vitro anti-tumor drug screenings are mainly performed by detecting the reaction of tumor cells in two-dimensional (2D) monolayer culture. Due to the convenient availability, 2D culture techniques are employed prior to in vivo in most of the process of evaluations of the efficacy of anti-cancer drugs and their candidates. However, the efficacy in vitro apparently has become weak in feasibility because of the increase of clinical trials resulting in failure. This has at least partially been attributed to the fact that cells grown in 2D culture lack the complex three-dimensional (3D) tissue architecture that realizes cell–cell or cell–extracellular matrix (ECM) interactions which can mimic tumors in real patients. 3D cancer models reflecting the pathophysiology and the resistance to radiation or drugs in vivo offer vital approaches for the development of novel theranostic drugs and systems by high-throughput drug screening. On the other hand, a subpopulation of stem-like cells within the tumor tissue so-called cancer stem cells (CSCs) are currently considered responsible for the tumor progression and metastasis. Therefore, 3D models with CSCs should be feasible for the screening of drugs and the development of personalized medicine. In the current chapter, we describe a detailed protocol to develop a CSC-based organoid as the 3D model. In this protocol we are showing two effective ways to develop 3D models using suspension and/or embedded methods." @default.
- W4378194013 created "2023-05-26" @default.
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- W4378194013 date "2023-01-01" @default.
- W4378194013 modified "2023-09-30" @default.
- W4378194013 title "In Vitro Tumoroid Model Using Cancer Stem Cells" @default.
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- W4378194013 doi "https://doi.org/10.1007/978-981-99-1331-2_20" @default.
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