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- W4378212833 abstract "Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness, the latter is one responsible for potentiating the resistance to treatment, inter alia due to increased invasiveness. In recent years, glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements, whereas the impact of the cytoskeleton on invasiveness is well known. Although non-stem glioblastoma cells are less invasive than glioblastoma stem cells (GSCs), these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core cells. This suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism, as they may provide new invasion-related insights. Previously, we proved that interplay between metabolism and cytoskeleton existed in glioblastoma. Despite searching for cytoskeleton-related processes in which the investigated genes might have been involved, not only did we stumble across the relation to metabolism but also reported genes that were found to be implicated in stemness. Thus, dedicated research on these genes in GSCs seems justifiable and might reveal novel directions and/or biomarkers that could be utilized in the future. Herein, we review the previously identified cytoskeleton/metabolism-related genes through the prism of glioblastoma stemness." @default.
- W4378212833 created "2023-05-26" @default.
- W4378212833 creator A5014331071 @default.
- W4378212833 creator A5024883941 @default.
- W4378212833 creator A5025317264 @default.
- W4378212833 creator A5032027594 @default.
- W4378212833 creator A5081622124 @default.
- W4378212833 date "2023-05-26" @default.
- W4378212833 modified "2023-10-14" @default.
- W4378212833 title "Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations" @default.
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