FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378213980> ?p ?o ?g. }

• W4378213980 endingPage "2269.e4" @default.
• W4378213980 startingPage "2260" @default.
• W4378213980 abstract "The circuitry underlying the detection of visual motion in Drosophila melanogaster is one of the best studied networks in neuroscience. Lately, electron microscopy reconstructions, algorithmic models, and functional studies have proposed a common motif for the cellular circuitry of an elementary motion detector based on both supralinear enhancement for preferred direction and sublinear suppression for null-direction motion. In T5 cells, however, all columnar input neurons (Tm1, Tm2, Tm4, and Tm9) are excitatory. So, how is null-direction suppression realized there? Using two-photon calcium imaging in combination with thermogenetics, optogenetics, apoptotics, and pharmacology, we discovered that it is via CT1, the GABAergic large-field amacrine cell, where the different processes have previously been shown to act in an electrically isolated way. Within each column, CT1 receives excitatory input from Tm9 and Tm1 and provides the sign-inverted, now inhibitory input signal onto T5. Ablating CT1 or knocking down GABA-receptor subunit Rdl significantly broadened the directional tuning of T5 cells. It thus appears that the signal of Tm1 and Tm9 is used both as an excitatory input for preferred direction enhancement and, through a sign inversion within the Tm1/Tm9-CT1 microcircuit, as an inhibitory input for null-direction suppression." @default.
• W4378213980 created "2023-05-26" @default.
• W4378213980 creator A5001581142 @default.
• W4378213980 creator A5035037223 @default.
• W4378213980 creator A5064828114 @default.
• W4378213980 date "2023-06-01" @default.
• W4378213980 modified "2023-10-14" @default.
• W4378213980 title "Disynaptic inhibition shapes tuning of OFF-motion detectors in Drosophila" @default.
• W4378213980 cites W1647075334 @default.
• W4378213980 cites W1788106766 @default.
• W4378213980 cites W1948084824 @default.
• W4378213980 cites W1977433867 @default.
• W4378213980 cites W1980641455 @default.
• W4378213980 cites W1984175894 @default.
• W4378213980 cites W1989621138 @default.
• W4378213980 cites W1991762922 @default.
• W4378213980 cites W1993569414 @default.
• W4378213980 cites W1998105194 @default.
• W4378213980 cites W2006067904 @default.
• W4378213980 cites W2018837082 @default.
• W4378213980 cites W2023874864 @default.
• W4378213980 cites W2024782085 @default.
• W4378213980 cites W2025654941 @default.
• W4378213980 cites W2033522594 @default.
• W4378213980 cites W2034262791 @default.
• W4378213980 cites W2041629876 @default.
• W4378213980 cites W2050121548 @default.
• W4378213980 cites W2058082904 @default.
• W4378213980 cites W2062074945 @default.
• W4378213980 cites W2070154123 @default.
• W4378213980 cites W2082705554 @default.
• W4378213980 cites W2092098765 @default.
• W4378213980 cites W2104228780 @default.
• W4378213980 cites W2122849962 @default.
• W4378213980 cites W2137413309 @default.
• W4378213980 cites W2150972545 @default.
• W4378213980 cites W2152434742 @default.
• W4378213980 cites W2159133821 @default.
• W4378213980 cites W2160032358 @default.
• W4378213980 cites W2174781702 @default.
• W4378213980 cites W2274876050 @default.
• W4378213980 cites W2302230753 @default.
• W4378213980 cites W2414343162 @default.
• W4378213980 cites W2486948773 @default.
• W4378213980 cites W2510794071 @default.
• W4378213980 cites W2597763782 @default.
• W4378213980 cites W2605475473 @default.
• W4378213980 cites W2765577635 @default.
• W4378213980 cites W2781555497 @default.
• W4378213980 cites W2808353537 @default.
• W4378213980 cites W2885496356 @default.
• W4378213980 cites W2910016083 @default.
• W4378213980 cites W2940988776 @default.
• W4378213980 cites W2949808130 @default.
• W4378213980 cites W2987022531 @default.
• W4378213980 cites W2988600856 @default.
• W4378213980 cites W2995517184 @default.
• W4378213980 cites W2999804811 @default.
• W4378213980 cites W3092750717 @default.
• W4378213980 cites W3174415204 @default.
• W4378213980 cites W3193875008 @default.
• W4378213980 cites W3205952889 @default.
• W4378213980 cites W4206755867 @default.
• W4378213980 cites W4212952892 @default.
• W4378213980 cites W4213435196 @default.
• W4378213980 doi "https://doi.org/10.1016/j.cub.2023.05.007" @default.
• W4378213980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37236181" @default.
• W4378213980 hasPublicationYear "2023" @default.
• W4378213980 type Work @default.
• W4378213980 citedByCount "2" @default.
• W4378213980 countsByYear W43782139802023 @default.
• W4378213980 crossrefType "journal-article" @default.
• W4378213980 hasAuthorship W4378213980A5001581142 @default.
• W4378213980 hasAuthorship W4378213980A5035037223 @default.
• W4378213980 hasAuthorship W4378213980A5064828114 @default.
• W4378213980 hasBestOaLocation W43782139801 @default.
• W4378213980 hasConcept C104317684 @default.
• W4378213980 hasConcept C112592302 @default.
• W4378213980 hasConcept C121332964 @default.
• W4378213980 hasConcept C169760540 @default.
• W4378213980 hasConcept C17077164 @default.
• W4378213980 hasConcept C191897082 @default.
• W4378213980 hasConcept C192562407 @default.
• W4378213980 hasConcept C2776032975 @default.
• W4378213980 hasConcept C2779177108 @default.
• W4378213980 hasConcept C2780104201 @default.
• W4378213980 hasConcept C50738837 @default.
• W4378213980 hasConcept C519063684 @default.
• W4378213980 hasConcept C54355233 @default.
• W4378213980 hasConcept C86803240 @default.
• W4378213980 hasConceptScore W4378213980C104317684 @default.
• W4378213980 hasConceptScore W4378213980C112592302 @default.
• W4378213980 hasConceptScore W4378213980C121332964 @default.
• W4378213980 hasConceptScore W4378213980C169760540 @default.
• W4378213980 hasConceptScore W4378213980C17077164 @default.
• W4378213980 hasConceptScore W4378213980C191897082 @default.
• W4378213980 hasConceptScore W4378213980C192562407 @default.
• W4378213980 hasConceptScore W4378213980C2776032975 @default.

• next