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- W4378214982 abstract "Tendinopathies are debilitating diseases currently increasing in prevalence and associated costs. There is a need to deepen our understanding of the underlying cell signaling pathways to unlock effective treatments. In this work, we screen cell signaling pathways in human tendinopathies and find enriched IL-6/JAK/STAT signaling alongside signatures of cell populations typically activated by IL-6 in other tissues. To dissect the underlying causalities, we combine IL-6 knock-out mice with an explant-based assembloid model of tendon damage to successfully connect IL-6 signaling to fibroblast progenitor activation and recruitment. Vice versa, we show that these fibroblast progenitors promote the development of tendinopathy hallmarks in the damaged explant upon IL-6 activation. Finally, we present in vivo data confirming diminished migration of progenitors to acute Achilles tendon lesions in IL-6 knock-out mice. We conclude that IL-6 activates tendon tissues to initiate normal healing processes that can deteriorate into tendinopathy hallmarks." @default.
- W4378214982 created "2023-05-26" @default.
- W4378214982 date "2023-05-25" @default.
- W4378214982 modified "2023-09-24" @default.
- W4378214982 title "Reviewer #1 (Public Review): IL-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating progenitor proliferation & migration to damage" @default.
- W4378214982 doi "https://doi.org/10.7554/elife.87092.1.sa1" @default.
- W4378214982 hasPublicationYear "2023" @default.
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