Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378214983> ?p ?o ?g. }
Showing items 1 to 35 of
35
with 100 items per page.
- W4378214983 abstract "Foxb1-expressing neurons occur in the dorsal premammillary nucleus (PMd) and further rostrally in the parvafox nucleus, a longitudinal cluster of neurons in the lateral hypothalamus of rodents. The descending projection of these Foxb1+ neurons end in the dorsolateral part of the periaqueductal gray (dlPAG). The functional role of the Foxb1+ neuronal subpopulation in the PMd and the parvafox nucleus remains elusive. In this study, the activity of the Foxb1+ neurons and of their terminal endings in the dlPAG was selectively altered by employing chemo- and optogenetic tools. Our results show that in whole-body barometric plethysmography, hM3Dq-mediated, global Foxb1+ neuron excitation activates respiration. Time-resolved optogenetic gain-of-function manipulation of the terminal endings of Foxb1+ neurons in the rostral third of the dlPAG leads to abrupt immobility and bradycardia. Chemogenetic activation of Foxb1+ cell bodies and ChR2-mediated excitation of their axonal endings in the dlPAG led to a phenotypical presentation congruent with a “freezing-like” situation during innate defensive behavior.Contact: Marco R. Celio, marco.celio@unifr.ch. The authors have no relevant financial or non-financial interests to disclose.Due to their storage in a university database, the datasets generated during the current study are not publicly available but are available from the corresponding author on reasonable request.This work was supported by the Swiss National Foundation grant 31003A_160325 to Marco R. Celio." @default.
- W4378214983 created "2023-05-26" @default.
- W4378214983 date "2023-05-25" @default.
- W4378214983 modified "2023-10-18" @default.
- W4378214983 title "Reviewer #2 (Public Review): Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility" @default.
- W4378214983 doi "https://doi.org/10.7554/elife.86737.1.sa2" @default.
- W4378214983 hasPublicationYear "2023" @default.
- W4378214983 type Work @default.
- W4378214983 citedByCount "0" @default.
- W4378214983 crossrefType "peer-review" @default.
- W4378214983 hasBestOaLocation W43782149831 @default.
- W4378214983 hasConcept C169760540 @default.
- W4378214983 hasConcept C2780723820 @default.
- W4378214983 hasConcept C50738837 @default.
- W4378214983 hasConcept C86803240 @default.
- W4378214983 hasConceptScore W4378214983C169760540 @default.
- W4378214983 hasConceptScore W4378214983C2780723820 @default.
- W4378214983 hasConceptScore W4378214983C50738837 @default.
- W4378214983 hasConceptScore W4378214983C86803240 @default.
- W4378214983 hasLocation W43782149831 @default.
- W4378214983 hasOpenAccess W4378214983 @default.
- W4378214983 hasPrimaryLocation W43782149831 @default.
- W4378214983 hasRelatedWork W1987269193 @default.
- W4378214983 hasRelatedWork W2021308189 @default.
- W4378214983 hasRelatedWork W2435758087 @default.
- W4378214983 hasRelatedWork W2802231275 @default.
- W4378214983 hasRelatedWork W2913368251 @default.
- W4378214983 hasRelatedWork W3087194547 @default.
- W4378214983 hasRelatedWork W3096957045 @default.
- W4378214983 hasRelatedWork W4206477879 @default.
- W4378214983 hasRelatedWork W4206570293 @default.
- W4378214983 hasRelatedWork W642420035 @default.
- W4378214983 isParatext "false" @default.
- W4378214983 isRetracted "false" @default.
- W4378214983 workType "peer-review" @default.