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- W4378215574 abstract "Phlorotannins are natural polyphenolic compounds produced by brown marine algae and are currently found in nutritional supplements. Although they are known to cross the blood-brain barrier, their neuropharmacological actions remain unclear. Here we review the potential therapeutic benefits of phlorotannins in the treatment of neurodegenerative diseases. In mouse models of Alzheimer's disease, ethanol intoxication and fear stress, the phlorotannin monomer phloroglucinol and the compounds eckol, dieckol and phlorofucofuroeckol A have been shown to improve cognitive function. In a mouse model of Parkinson's disease, phloroglucinol treatment led to improved motor performance. Additional neurological benefits associated with phlorotannin intake have been demonstrated in stroke, sleep disorders, and pain response. These effects may stem from the inhibition of disease-inducing plaque synthesis and aggregation, suppression of microglial activation, modulation of pro-inflammatory signaling, reduction of glutamate-induced excitotoxicity, and scavenging of reactive oxygen species. Clinical trials of phlorotannins have not reported significant adverse effects, suggesting these compounds to be promising bioactive agents in the treatment of neurological diseases. We therefore propose a putative biophysical mechanism of phlorotannin action in addition to future directions for phlorotannin research." @default.
- W4378215574 created "2023-05-26" @default.
- W4378215574 creator A5012622147 @default.
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- W4378215574 creator A5049314220 @default.
- W4378215574 date "2023-05-18" @default.
- W4378215574 modified "2023-09-26" @default.
- W4378215574 title "Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders" @default.
- W4378215574 cites W1510439895 @default.
- W4378215574 cites W1534087190 @default.
- W4378215574 cites W1613451007 @default.
- W4378215574 cites W1613810133 @default.
- W4378215574 cites W1657989568 @default.
- W4378215574 cites W1697463694 @default.
- W4378215574 cites W1837384645 @default.
- W4378215574 cites W1865451986 @default.
- W4378215574 cites W1925423442 @default.
- W4378215574 cites W1964666059 @default.
- W4378215574 cites W1967973420 @default.
- W4378215574 cites W1968812021 @default.
- W4378215574 cites W1969074927 @default.
- W4378215574 cites W1969397544 @default.
- W4378215574 cites W1970908183 @default.
- W4378215574 cites W1973238388 @default.
- W4378215574 cites W1974966491 @default.
- W4378215574 cites W1977721565 @default.
- W4378215574 cites W1978751701 @default.
- W4378215574 cites W1982190221 @default.
- W4378215574 cites W1984547380 @default.
- W4378215574 cites W1984649584 @default.
- W4378215574 cites W1985005169 @default.
- W4378215574 cites W1988302458 @default.
- W4378215574 cites W1989411375 @default.
- W4378215574 cites W1991994462 @default.
- W4378215574 cites W2006200262 @default.
- W4378215574 cites W2006869862 @default.
- W4378215574 cites W2011982570 @default.
- W4378215574 cites W2013503732 @default.
- W4378215574 cites W2014017631 @default.
- W4378215574 cites W2016384690 @default.
- W4378215574 cites W2024318295 @default.
- W4378215574 cites W2026960642 @default.
- W4378215574 cites W2027958854 @default.
- W4378215574 cites W2029680043 @default.
- W4378215574 cites W2034504333 @default.
- W4378215574 cites W2035956505 @default.
- W4378215574 cites W2036177953 @default.
- W4378215574 cites W2038594716 @default.
- W4378215574 cites W2040479942 @default.
- W4378215574 cites W2040591631 @default.
- W4378215574 cites W2041207243 @default.
- W4378215574 cites W2044355904 @default.
- W4378215574 cites W2046762377 @default.
- W4378215574 cites W2047514208 @default.
- W4378215574 cites W2047546727 @default.
- W4378215574 cites W2049748068 @default.
- W4378215574 cites W2050386656 @default.
- W4378215574 cites W2050496541 @default.
- W4378215574 cites W2050844226 @default.
- W4378215574 cites W2052530454 @default.
- W4378215574 cites W2052652421 @default.
- W4378215574 cites W2052727812 @default.
- W4378215574 cites W2053770559 @default.
- W4378215574 cites W2055275688 @default.
- W4378215574 cites W2055557007 @default.
- W4378215574 cites W2056798863 @default.
- W4378215574 cites W2058151436 @default.
- W4378215574 cites W2062993540 @default.
- W4378215574 cites W2074274825 @default.
- W4378215574 cites W2075718968 @default.
- W4378215574 cites W2078117880 @default.
- W4378215574 cites W2079286959 @default.
- W4378215574 cites W2082429191 @default.
- W4378215574 cites W2084142451 @default.
- W4378215574 cites W2086162146 @default.
- W4378215574 cites W2090586279 @default.
- W4378215574 cites W2091774132 @default.
- W4378215574 cites W2092438659 @default.
- W4378215574 cites W209376154 @default.
- W4378215574 cites W2097506068 @default.
- W4378215574 cites W2097981235 @default.
- W4378215574 cites W2099410079 @default.
- W4378215574 cites W2102486094 @default.
- W4378215574 cites W2103409373 @default.
- W4378215574 cites W2105679283 @default.
- W4378215574 cites W2109036426 @default.
- W4378215574 cites W2111200377 @default.
- W4378215574 cites W2112455323 @default.
- W4378215574 cites W2117715759 @default.
- W4378215574 cites W2120973557 @default.
- W4378215574 cites W2121488008 @default.
- W4378215574 cites W2122367304 @default.
- W4378215574 cites W2126402425 @default.
- W4378215574 cites W2131909570 @default.
- W4378215574 cites W2135482947 @default.
- W4378215574 cites W2136001232 @default.
- W4378215574 cites W2146550933 @default.
- W4378215574 cites W2148882983 @default.