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- W4378220507 abstract "During tissue development, gradients of secreted signaling molecules known as morphogens provide cells with positional information. The mechanisms underlying morphogen spreading have been widely studied, however, it remains largely unexplored whether the shape of morphogen gradients is influenced by tissue morphology. Here, we developed an analysis pipeline to quantify the distribution of proteins within a curved tissue. We applied it to the Hedgehog morphogen gradient in the Drosophila wing and eye-antennal imaginal discs, which are flat and curved tissues, respectively. Despite a different expression profile, the slope of the Hedgehog gradient was comparable between the two tissues. Moreover, inducing ectopic folds in wing imaginal discs did not affect the slope of the Hedgehog gradient. Suppressing curvature in the eye-antennal imaginal disc also did not alter the Hedgehog gradient slope but led to ectopic Hedgehog expression. In conclusion, through the development of an analysis pipeline that allows quantifying protein distribution in curved tissues, we show that the Hedgehog gradient is robust towards variations in tissue morphology." @default.
- W4378220507 created "2023-05-26" @default.
- W4378220507 creator A5037466226 @default.
- W4378220507 creator A5062579072 @default.
- W4378220507 date "2023-05-25" @default.
- W4378220507 modified "2023-09-25" @default.
- W4378220507 title "Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila" @default.
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- W4378220507 doi "https://doi.org/10.1038/s41598-023-34632-8" @default.
- W4378220507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37231029" @default.
- W4378220507 hasPublicationYear "2023" @default.
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