FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378220990> ?p ?o ?g. }

• W4378220990 abstract "The current study aimed to examine the association between the number of medications, polypharmacy, and frailty in community-dwelling older adults. In addition, the cutoff score for the number of medications related with frailty in this sample was determined.A cross-sectional analysis was performed using data of 328 individual aged between 65 and 85 years from the Midlife in the United States (MIDUS 2): Biomarker Project, 2004-2009, a multisite longitudinal study, for 328 individuals aged between 65 and 85 years. All the participants were categorized into two groups based on the number of medications used: no polypharmacy (n = 206) and polypharmacy (n = 122). The polypharmacy was defined as having 5 or more medication per day. Frailty status was measured using a modified form of Fried frailty phenotype through the presences of the following indicators include low physical activity; exhaustion; weight loss; slow gait speed and muscle weakness. Participants were categorized into three different groups based on total score: 0 as robust, 1 to 2 as prefrail, 3 or more as frail. The relationship between no. of medications, polypharmacy, and frailty was examined using a multinomial logistic regression model. The model was adjusted for age, sex, BMI, and no. of chronic conditions. Receiver operator characteristics and area under the curve were used to determine the cutoff number of medications.Number of medications, and polypharmacy were associated with being frail (relative risk ratio [RRR]: 1.30; 95% confidence interval [CI]: [1.12, 1.50], p = 0.001), (RRR: 4.77; 95% CI [1.69, 13.4], p = 0.003), respectively. Number of medications with cutoff 6 medication or more was associated with being in frail category with sensitivity of 62% and specificity of 73%.Polypharmacy was shown to be significantly related to frailty. A cutoff score of 6 or more medications distinguished frail from non-frail. Addressing polypharmacy in the older population might ameliorate the impact of physical frailty." @default.
• W4378220990 created "2023-05-26" @default.
• W4378220990 creator A5010331137 @default.
• W4378220990 date "2023-05-25" @default.
• W4378220990 modified "2023-09-30" @default.
• W4378220990 title "Number of medications and polypharmacy are associated with frailty in older adults: results from the Midlife in the United States study" @default.
• W4378220990 cites W1958056332 @default.
• W4378220990 cites W1963245484 @default.
• W4378220990 cites W1963867953 @default.
• W4378220990 cites W1967392886 @default.
• W4378220990 cites W1992990069 @default.
• W4378220990 cites W1996161169 @default.
• W4378220990 cites W2138664855 @default.
• W4378220990 cites W2149485684 @default.
• W4378220990 cites W2164059021 @default.
• W4378220990 cites W2307587177 @default.
• W4378220990 cites W2563023099 @default.
• W4378220990 cites W2604965609 @default.
• W4378220990 cites W2794077735 @default.
• W4378220990 cites W2889219031 @default.
• W4378220990 cites W2979434443 @default.
• W4378220990 cites W3093385449 @default.
• W4378220990 cites W3136164744 @default.
• W4378220990 cites W4220969512 @default.
• W4378220990 doi "https://doi.org/10.3389/fpubh.2023.1148671" @default.
• W4378220990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37304087" @default.
• W4378220990 hasPublicationYear "2023" @default.
• W4378220990 type Work @default.
• W4378220990 citedByCount "0" @default.
• W4378220990 crossrefType "journal-article" @default.
• W4378220990 hasAuthorship W4378220990A5010331137 @default.
• W4378220990 hasBestOaLocation W43782209901 @default.
• W4378220990 hasConcept C117568660 @default.
• W4378220990 hasConcept C118552586 @default.
• W4378220990 hasConcept C119857082 @default.
• W4378220990 hasConcept C126322002 @default.
• W4378220990 hasConcept C144024400 @default.
• W4378220990 hasConcept C149923435 @default.
• W4378220990 hasConcept C151956035 @default.
• W4378220990 hasConcept C36434225 @default.
• W4378220990 hasConcept C41008148 @default.
• W4378220990 hasConcept C44249647 @default.
• W4378220990 hasConcept C54183767 @default.
• W4378220990 hasConcept C58471807 @default.
• W4378220990 hasConcept C71924100 @default.
• W4378220990 hasConcept C74909509 @default.
• W4378220990 hasConceptScore W4378220990C117568660 @default.
• W4378220990 hasConceptScore W4378220990C118552586 @default.
• W4378220990 hasConceptScore W4378220990C119857082 @default.
• W4378220990 hasConceptScore W4378220990C126322002 @default.
• W4378220990 hasConceptScore W4378220990C144024400 @default.
• W4378220990 hasConceptScore W4378220990C149923435 @default.
• W4378220990 hasConceptScore W4378220990C151956035 @default.
• W4378220990 hasConceptScore W4378220990C36434225 @default.
• W4378220990 hasConceptScore W4378220990C41008148 @default.
• W4378220990 hasConceptScore W4378220990C44249647 @default.
• W4378220990 hasConceptScore W4378220990C54183767 @default.
• W4378220990 hasConceptScore W4378220990C58471807 @default.
• W4378220990 hasConceptScore W4378220990C71924100 @default.
• W4378220990 hasConceptScore W4378220990C74909509 @default.
• W4378220990 hasLocation W43782209901 @default.
• W4378220990 hasLocation W43782209902 @default.
• W4378220990 hasLocation W43782209903 @default.
• W4378220990 hasOpenAccess W4378220990 @default.
• W4378220990 hasPrimaryLocation W43782209901 @default.
• W4378220990 hasRelatedWork W2318279345 @default.
• W4378220990 hasRelatedWork W2465911618 @default.
• W4378220990 hasRelatedWork W2611007169 @default.
• W4378220990 hasRelatedWork W3087605753 @default.
• W4378220990 hasRelatedWork W3087709819 @default.
• W4378220990 hasRelatedWork W3132856804 @default.
• W4378220990 hasRelatedWork W3191223673 @default.
• W4378220990 hasRelatedWork W3193894338 @default.
• W4378220990 hasRelatedWork W4237444705 @default.
• W4378220990 hasRelatedWork W4317659509 @default.
• W4378220990 hasVolume "11" @default.
• W4378220990 isParatext "false" @default.
• W4378220990 isRetracted "false" @default.
• W4378220990 workType "article" @default.