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• W4378221457 abstract "Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) are common neurodevelopmental disorders. Clinically, there is extensive overlap between the symptoms of both disorders, which poses a major diagnostic challenge. This study examined the heterogeneity of ASD and ADHD by selecting indicators derived from neuropsychological and/or neuroimaging tests, and using the Support Vector Machine (SVM) algorithm to conduct research on high-functioning ASD and ADHD, so as to further elucidate the significance of different indicators in the differentiation of these two disorders. From January 2018 to June 2019, 33 children with high-functioning ASD, 35 with high-functioning ADHD and 30 typically developing (TD) children were recruited in the community during the same period and enrolled in the study. All participants were required to avoid taking neuropsychiatric drugs for 1 week before functional magnetic resonance imaging was conducted, and to stay awake and to minimize head motion during scans. Then, the collected brain image data were preprocessed to ReHo index on the dparsfa (http://www.restfmri.net/forum/DPARSF) platform, and differences in the regional homogeneity (ReHo) value of the three groups of subjects were compared and analyzed using Statistical Parametric Matching software, which took into account ReHo classification characteristics. Spearman’s correlation analysis was carried out to analyze the voxel values of the extracted difference masses correlated with the category labels, and the support vector machine method was employed to respectively test the classification accuracy of the single ReHo index for the three groups of participants and the accuracy of constructing model discrimination type in joint behavioral indexes. A comparative analysis of differences in ReHo characteristics among the three groups showed differences in SupraMarginal_R, Parietal_Sup_L, Parietal_Inf_R and Cerebelum_Crus2_L (<I>P</I> < 0.05). The distribution of relative ReHo values in this mass region was TD>ASD>ADHD, and the difference was statistically significant (<I>P </I>< 0.05). Further extracting voxel values of the three groups, using the participants' differential masses as characteristics, it was found that the maximum classification Accuracy (ACC) and Area Under Curve (AUC) of the brain resting-state local consistency index (ReHo) were 60.74% and 0.6671, respectively. Compared with the classification using resting-state local consistency (ReHo) features alone, the maximum ACC and AUC in combination with ReHo index and specific scale features were 73.53% and 0.7943, respectively. Classification accuracy was improved when combining a specific scale with the ReHo index, and this may prove more helpful for clinical auxiliary diagnosis." @default.
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• W4378221457 date "2023-05-25" @default.
• W4378221457 modified "2023-10-01" @default.
• W4378221457 title "Research on Pattern Classification of Autism Spectrum Disorder Related to the Diagnosis of Attention Deficit Hyperactivity Disorder" @default.
• W4378221457 doi "https://doi.org/10.57237/j.mrf.2023.02.003" @default.
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