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- W4378226667 endingPage "9235" @default.
- W4378226667 startingPage "9235" @default.
- W4378226667 abstract "Cancer is the leading cause of death worldwide despite the variety of treatments that are currently used. This is due to an innate or acquired resistance to therapy that encourages the discovery of novel therapeutic strategies to overcome the resistance. This review will focus on the role of the purinergic receptor P2RX7 in the control of tumor growth, through its ability to modulate antitumor immunity by releasing IL-18. In particular, we describe how the ATP-induced receptor activities (cationic exchange, large pore opening and NLRP3 inflammasome activation) modulate immune cell functions. Furthermore, we recapitulate our current knowledge of the production of IL-18 downstream of P2RX7 activation and how IL-18 controls the fate of tumor growth. Finally, the potential of targeting the P2RX7/IL-18 pathway in combination with classical immunotherapies to fight cancer is discussed." @default.
- W4378226667 created "2023-05-26" @default.
- W4378226667 creator A5046085675 @default.
- W4378226667 creator A5076655031 @default.
- W4378226667 creator A5089171072 @default.
- W4378226667 date "2023-05-25" @default.
- W4378226667 modified "2023-10-15" @default.
- W4378226667 title "The Role of IL-18 in P2RX7-Mediated Antitumor Immunity" @default.
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