FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378229850> ?p ?o ?g. }

• W4378229850 endingPage "1590" @default.
• W4378229850 startingPage "1590" @default.
• W4378229850 abstract "Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on the anticancer effect; therefore, the design of the nanocarrier and the mechanisms that govern drug release play a crucial role in optimizing efficacy. Here, we synthesized and characterized mesoporous silica nanoparticles with transferrin conjugated on their surface via a pH-sensitive imine bond (MSN-Tf) to assess camptothecin (CPT) loading and release. The results showed that CPT-loaded MSN-Tf (MSN-Tf@CPT) had a size of ca. 90 nm, a zeta potential of -18.9 mV, and a loaded content of 13.4%. The release kinetic data best fit a first-order model, and the predominant mechanism was Fickian diffusion. Additionally, a three-parameter model demonstrated the drug-matrix interaction and impact of transferrin in controlling the release of CPT from the nanocarrier. Taken together, these results provide new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem." @default.
• W4378229850 created "2023-05-26" @default.
• W4378229850 creator A5007673600 @default.
• W4378229850 creator A5029964563 @default.
• W4378229850 creator A5047332923 @default.
• W4378229850 creator A5064147386 @default.
• W4378229850 creator A5084243469 @default.
• W4378229850 date "2023-05-25" @default.
• W4378229850 modified "2023-09-27" @default.
• W4378229850 title "Kinetics and Mechanism of Camptothecin Release from Transferrin-Gated Mesoporous Silica Nanoparticles through a pH-Responsive Surface Linker" @default.
• W4378229850 cites W1968583232 @default.
• W4378229850 cites W1985724892 @default.
• W4378229850 cites W1993390114 @default.
• W4378229850 cites W1996897622 @default.
• W4378229850 cites W1997683856 @default.
• W4378229850 cites W2000070641 @default.
• W4378229850 cites W2000352722 @default.
• W4378229850 cites W2001872244 @default.
• W4378229850 cites W2005814056 @default.
• W4378229850 cites W2009841111 @default.
• W4378229850 cites W2027333133 @default.
• W4378229850 cites W2032838599 @default.
• W4378229850 cites W2040955353 @default.
• W4378229850 cites W2042805308 @default.
• W4378229850 cites W2043503083 @default.
• W4378229850 cites W2050656614 @default.
• W4378229850 cites W2059674127 @default.
• W4378229850 cites W2068050569 @default.
• W4378229850 cites W2070534090 @default.
• W4378229850 cites W2076614074 @default.
• W4378229850 cites W2078847302 @default.
• W4378229850 cites W2095194582 @default.
• W4378229850 cites W2099567846 @default.
• W4378229850 cites W2103244979 @default.
• W4378229850 cites W2115439624 @default.
• W4378229850 cites W2143725055 @default.
• W4378229850 cites W2315317351 @default.
• W4378229850 cites W2322439628 @default.
• W4378229850 cites W2346594379 @default.
• W4378229850 cites W2417111098 @default.
• W4378229850 cites W2476770291 @default.
• W4378229850 cites W2534211387 @default.
• W4378229850 cites W2547470703 @default.
• W4378229850 cites W2559014585 @default.
• W4378229850 cites W2564677988 @default.
• W4378229850 cites W2580540702 @default.
• W4378229850 cites W2605677864 @default.
• W4378229850 cites W2608200058 @default.
• W4378229850 cites W2624317658 @default.
• W4378229850 cites W2753899156 @default.
• W4378229850 cites W2755677304 @default.
• W4378229850 cites W2775157736 @default.
• W4378229850 cites W2777046800 @default.
• W4378229850 cites W2782051524 @default.
• W4378229850 cites W2784977455 @default.
• W4378229850 cites W2803669882 @default.
• W4378229850 cites W2803959761 @default.
• W4378229850 cites W2896130004 @default.
• W4378229850 cites W2899249829 @default.
• W4378229850 cites W2908861038 @default.
• W4378229850 cites W2939834596 @default.
• W4378229850 cites W2955521955 @default.
• W4378229850 cites W2981215046 @default.
• W4378229850 cites W2995924682 @default.
• W4378229850 cites W2999106070 @default.
• W4378229850 cites W3004649371 @default.
• W4378229850 cites W3008673236 @default.
• W4378229850 cites W3013322675 @default.
• W4378229850 cites W3015618796 @default.
• W4378229850 cites W3048544274 @default.
• W4378229850 cites W3082246294 @default.
• W4378229850 cites W3087187510 @default.
• W4378229850 cites W3093021614 @default.
• W4378229850 cites W3106940282 @default.
• W4378229850 cites W3119636523 @default.
• W4378229850 cites W3128167085 @default.
• W4378229850 cites W3133997346 @default.
• W4378229850 cites W3165750686 @default.
• W4378229850 cites W4221102811 @default.
• W4378229850 cites W4235476133 @default.
• W4378229850 cites W4281680654 @default.
• W4378229850 cites W4282960434 @default.
• W4378229850 cites W4293581515 @default.
• W4378229850 cites W4293752108 @default.
• W4378229850 cites W4296033705 @default.
• W4378229850 cites W4297069849 @default.
• W4378229850 cites W4297833203 @default.
• W4378229850 cites W4313703128 @default.
• W4378229850 cites W4315754639 @default.
• W4378229850 cites W4320038999 @default.
• W4378229850 cites W4320402006 @default.
• W4378229850 doi "https://doi.org/10.3390/pharmaceutics15061590" @default.
• W4378229850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37376039" @default.
• W4378229850 hasPublicationYear "2023" @default.
• W4378229850 type Work @default.
• W4378229850 citedByCount "0" @default.
• W4378229850 crossrefType "journal-article" @default.
• W4378229850 hasAuthorship W4378229850A5007673600 @default.

• next