Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378231504> ?p ?o ?g. }
- W4378231504 endingPage "124980" @default.
- W4378231504 startingPage "124980" @default.
- W4378231504 abstract "Mucoadhesive polymers and their nanoparticles have attracted a lot of attention in pharmaceutical applications, especially transmucosal drug delivery (TDD). Mucoadhesive polysaccharide-based nanoparticles, particularly chitosan, and its derivatives, are widely used for TDD owing to their outstanding features such as biocompatibility, mucoadhesive, and absorption-enhancing properties. Herein, this study aimed to design potential mucoadhesive nanoparticles for the delivery of ciprofloxacin based on methacrylated chitosan (MeCHI) using the ionic gelation method in the presence of sodium tripolyphosphate (TPP) and compared them with the unmodified chitosan nanoparticles. In this study, different experimental conditions including the polymer to TPP mass ratios, NaCl, and TPP concentration were changed to achieve unmodified and MeCHI nanoparticles with the smallest particle size and lowest polydispersity index. At 4:1 polymer /TPP mass ratio, both chitosan and MeCHI nanoparticles had the smallest size (133 ± 5 nm and 206 ± 9 nm, respectively). MeCHI nanoparticles were generally larger and slightly more polydisperse than the unmodified chitosan nanoparticles. Ciprofloxacin-loaded MeCHI nanoparticles had the highest encapsulation efficiency (69 ± 13 %) at 4:1 MeCHI /TPP mass ratio and 0.5 mg/mL TPP, but similar encapsulation efficiency to that of their chitosan counterpart at 1 mg/mL TPP. They also provided a more sustained and slower drug release compared to their chitosan counterpart. Additionally, the mucoadhesion (retention) study on sheep abomasum mucosa showed that ciprofloxacin-loaded MeCHI nanoparticles with optimized TPP concentration had better retention than the unmodified chitosan counterpart. The percentage of the remained ciprofloxacin-loaded MeCHI and chitosan nanoparticles on the mucosal surface was 96 % and 88 %, respectively. Therefore, MeCHI nanoparticles have an excellent potential for applications in drug delivery." @default.
- W4378231504 created "2023-05-26" @default.
- W4378231504 creator A5020852141 @default.
- W4378231504 creator A5035211736 @default.
- W4378231504 creator A5037839028 @default.
- W4378231504 creator A5042629168 @default.
- W4378231504 creator A5086472797 @default.
- W4378231504 date "2023-07-01" @default.
- W4378231504 modified "2023-10-17" @default.
- W4378231504 title "Preparation of mucoadhesive methacrylated chitosan nanoparticles for delivery of ciprofloxacin" @default.
- W4378231504 cites W160189274 @default.
- W4378231504 cites W1971645600 @default.
- W4378231504 cites W1975530828 @default.
- W4378231504 cites W1983198703 @default.
- W4378231504 cites W1992577489 @default.
- W4378231504 cites W1992865921 @default.
- W4378231504 cites W1994638195 @default.
- W4378231504 cites W1998624966 @default.
- W4378231504 cites W2006845797 @default.
- W4378231504 cites W2008814769 @default.
- W4378231504 cites W2012897009 @default.
- W4378231504 cites W2022359813 @default.
- W4378231504 cites W2053798531 @default.
- W4378231504 cites W2062246286 @default.
- W4378231504 cites W2063805677 @default.
- W4378231504 cites W2068554406 @default.
- W4378231504 cites W2068833428 @default.
- W4378231504 cites W2072532676 @default.
- W4378231504 cites W2073299869 @default.
- W4378231504 cites W2075111713 @default.
- W4378231504 cites W2085250824 @default.
- W4378231504 cites W2106169256 @default.
- W4378231504 cites W2143429479 @default.
- W4378231504 cites W2161315926 @default.
- W4378231504 cites W2165294982 @default.
- W4378231504 cites W2170919433 @default.
- W4378231504 cites W2305359499 @default.
- W4378231504 cites W2567619704 @default.
- W4378231504 cites W2617735808 @default.
- W4378231504 cites W2768654546 @default.
- W4378231504 cites W2788601587 @default.
- W4378231504 cites W2793485037 @default.
- W4378231504 cites W2795056256 @default.
- W4378231504 cites W2811157243 @default.
- W4378231504 cites W2887557054 @default.
- W4378231504 cites W2907115174 @default.
- W4378231504 cites W2943980311 @default.
- W4378231504 cites W2958545592 @default.
- W4378231504 cites W2959776995 @default.
- W4378231504 cites W2988168093 @default.
- W4378231504 cites W3010291755 @default.
- W4378231504 cites W3023307241 @default.
- W4378231504 cites W3024412529 @default.
- W4378231504 cites W3081130963 @default.
- W4378231504 cites W3085299524 @default.
- W4378231504 cites W3092455672 @default.
- W4378231504 cites W3105299294 @default.
- W4378231504 cites W3124989431 @default.
- W4378231504 cites W3136263514 @default.
- W4378231504 cites W3182680757 @default.
- W4378231504 cites W3185941188 @default.
- W4378231504 cites W4200170966 @default.
- W4378231504 cites W4214634712 @default.
- W4378231504 cites W4220853288 @default.
- W4378231504 cites W4223559047 @default.
- W4378231504 cites W4224438297 @default.
- W4378231504 cites W4281294706 @default.
- W4378231504 cites W4283589865 @default.
- W4378231504 cites W4290025315 @default.
- W4378231504 cites W4294922015 @default.
- W4378231504 cites W4297231530 @default.
- W4378231504 cites W4306412456 @default.
- W4378231504 cites W4306761588 @default.
- W4378231504 cites W4310128058 @default.
- W4378231504 cites W4311577550 @default.
- W4378231504 cites W4312060979 @default.
- W4378231504 cites W4312083730 @default.
- W4378231504 cites W4318069404 @default.
- W4378231504 cites W4318480745 @default.
- W4378231504 cites W4319083459 @default.
- W4378231504 cites W4321019838 @default.
- W4378231504 doi "https://doi.org/10.1016/j.ijbiomac.2023.124980" @default.
- W4378231504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37236558" @default.
- W4378231504 hasPublicationYear "2023" @default.
- W4378231504 type Work @default.
- W4378231504 citedByCount "1" @default.
- W4378231504 countsByYear W43782315042023 @default.
- W4378231504 crossrefType "journal-article" @default.
- W4378231504 hasAuthorship W4378231504A5020852141 @default.
- W4378231504 hasAuthorship W4378231504A5035211736 @default.
- W4378231504 hasAuthorship W4378231504A5037839028 @default.
- W4378231504 hasAuthorship W4378231504A5042629168 @default.
- W4378231504 hasAuthorship W4378231504A5086472797 @default.
- W4378231504 hasConcept C11432220 @default.
- W4378231504 hasConcept C127413603 @default.
- W4378231504 hasConcept C13245373 @default.
- W4378231504 hasConcept C13965031 @default.
- W4378231504 hasConcept C155672457 @default.