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- W4378347617 abstract "Immune checkpoint blockade (ICB) therapy has shown remarkable outcomes along with multiple cases of complete regression in clinical practice. But unfortunately, most patients who have an immunosuppressive tumor immune microenvironment (TIME) respond poorly to these therapies. To improve the response rate of the patients, various treatment modalities that can boost cancer immunogenicity and remove immune tolerance have been combined with ICB therapies. However, the systemic administration of multiple immunotherapeutic agents can potentially cause severe off-target toxicities and immune-related adverse events, diminishing antitumor immunity and increasing the risk of additional complications. To address these problems, Immune Checkpoint-Targeted Drug Conjugates (IDCs) have been widely investigated for their ability to offer distinct advantages in remodeling the TIME for cancer immunotherapy. IDCs, consisting of immune checkpoint-targeting moieties, cleavable linkers, and payloads of immunotherapeutic agents, have a similar structure to conventional antibody-drug conjugates (ADCs) but target and block the immune checkpoint receptors, and then release the payloads conjugated through cleavable linkers. These unique mechanisms of IDCs prompt an immune-responsive TIME by modulating the multiple steps related to the cancer-immunity cycle, ultimately leading to tumor eradication. This review outlines the mode of action and advantages of IDCs. In addition, various IDCs for combinational immunotherapy are reviewed. Finally, the potential and challenges of IDCs for clinical translation are discussed." @default.
- W4378347617 created "2023-05-27" @default.
- W4378347617 creator A5026852861 @default.
- W4378347617 creator A5030603383 @default.
- W4378347617 creator A5031417330 @default.
- W4378347617 creator A5043658693 @default.
- W4378347617 creator A5056431102 @default.
- W4378347617 creator A5065066721 @default.
- W4378347617 creator A5073611697 @default.
- W4378347617 date "2023-07-01" @default.
- W4378347617 modified "2023-10-18" @default.
- W4378347617 title "Immune checkpoint-targeted drug conjugates: A promising tool for remodeling tumor immune microenvironment" @default.
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