FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378348439> ?p ?o ?g. }

• W4378348439 abstract "Pancreatic ductal adenocarcinoma remains one of the major causes of cancer-related mortality globally. Unfortunately, current prognostic biomarkers are limited, and no predictive biomarkers exist. This study examined promoter hypermethylation of secreted frizzled-related protein 1 (phSFRP1) in cfDNA as a prognostic biomarker and predictor of treatment effect in patients with metastatic FOLFIRINOX-treated PDAC and locally advanced PDAC. We performed methylation-specific PCR of the SFRP1 genes’ promoter region, based on bisulfite treatment. Survival was assessed as time-to-event data using the pseudo-observation method and analyzed with Kaplan-Meier curves and generalized linear regressions. The study included 52 patients with FOLFIRINOX-treated metastatic PDAC. Patients with unmethylated (um) SFRP1 (n = 29) had a longer median overall survival (15.7 months) than those with phSFRP1 (6.8 months). In crude regression, phSFRP1 was associated with an increased risk of death of 36.9% (95% CI 12.0%–61.7%) and 19.8% (95% CI 1.9–37.6) at 12 and 24-months, respectively. In supplementary regression analysis, interaction terms between SFRP1 methylation status and treatment were significant, indicating reduced benefit of chemotherapy. Forty-four patients with locally advanced PDAC were included. phSFRP1 was associated with an increased risk of death at 24-months This indicates that phSFRP1 is a clinically useful prognostic biomarker in metastatic PDAC and possibly in locally advanced PDAC. Together with existing literature, results could indicate the value of cfDNA-measured phSFRP1 as a predictive biomarker of standard palliative chemotherapy in patients with metastatic PDAC. This could facilitate personalized treatment of patients with metastatic PDAC." @default.
• W4378348439 created "2023-05-27" @default.
• W4378348439 creator A5017733773 @default.
• W4378348439 creator A5021015623 @default.
• W4378348439 creator A5027107917 @default.
• W4378348439 creator A5035783751 @default.
• W4378348439 creator A5053669248 @default.
• W4378348439 creator A5063670944 @default.
• W4378348439 creator A5065511737 @default.
• W4378348439 creator A5077266390 @default.
• W4378348439 creator A5082379448 @default.
• W4378348439 date "2023-05-01" @default.
• W4378348439 modified "2023-10-14" @default.
• W4378348439 title "Promoter hypermethylation of SFRP1 as a prognostic and potentially predictive blood-based biomarker in patients with stage III or IV pancreatic ductal adenocarcinoma" @default.
• W4378348439 cites W1477250673 @default.
• W4378348439 cites W1568187088 @default.
• W4378348439 cites W1758577516 @default.
• W4378348439 cites W1935378439 @default.
• W4378348439 cites W1937770528 @default.
• W4378348439 cites W1974652009 @default.
• W4378348439 cites W2048033270 @default.
• W4378348439 cites W2108557027 @default.
• W4378348439 cites W2117499849 @default.
• W4378348439 cites W2121419223 @default.
• W4378348439 cites W2139496687 @default.
• W4378348439 cites W2151253787 @default.
• W4378348439 cites W2154841427 @default.
• W4378348439 cites W2195297470 @default.
• W4378348439 cites W2403874820 @default.
• W4378348439 cites W2549339322 @default.
• W4378348439 cites W2563421353 @default.
• W4378348439 cites W2755243126 @default.
• W4378348439 cites W2760427416 @default.
• W4378348439 cites W2899311685 @default.
• W4378348439 cites W2971764330 @default.
• W4378348439 cites W3005741158 @default.
• W4378348439 cites W3006774878 @default.
• W4378348439 cites W3087564201 @default.
• W4378348439 cites W3162742754 @default.
• W4378348439 cites W3169516627 @default.
• W4378348439 cites W3174792946 @default.
• W4378348439 cites W3213238644 @default.
• W4378348439 cites W4206841660 @default.
• W4378348439 cites W4283024228 @default.
• W4378348439 cites W4295211195 @default.
• W4378348439 cites W4311162383 @default.
• W4378348439 cites W4317811232 @default.
• W4378348439 doi "https://doi.org/10.1016/j.pan.2023.05.003" @default.
• W4378348439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37230892" @default.
• W4378348439 hasPublicationYear "2023" @default.
• W4378348439 type Work @default.
• W4378348439 citedByCount "0" @default.
• W4378348439 crossrefType "journal-article" @default.
• W4378348439 hasAuthorship W4378348439A5017733773 @default.
• W4378348439 hasAuthorship W4378348439A5021015623 @default.
• W4378348439 hasAuthorship W4378348439A5027107917 @default.
• W4378348439 hasAuthorship W4378348439A5035783751 @default.
• W4378348439 hasAuthorship W4378348439A5053669248 @default.
• W4378348439 hasAuthorship W4378348439A5063670944 @default.
• W4378348439 hasAuthorship W4378348439A5065511737 @default.
• W4378348439 hasAuthorship W4378348439A5077266390 @default.
• W4378348439 hasAuthorship W4378348439A5082379448 @default.
• W4378348439 hasBestOaLocation W43783484391 @default.
• W4378348439 hasConcept C121608353 @default.
• W4378348439 hasConcept C126322002 @default.
• W4378348439 hasConcept C143998085 @default.
• W4378348439 hasConcept C146357865 @default.
• W4378348439 hasConcept C151730666 @default.
• W4378348439 hasConcept C185592680 @default.
• W4378348439 hasConcept C2777148230 @default.
• W4378348439 hasConcept C2780210213 @default.
• W4378348439 hasConcept C2780521871 @default.
• W4378348439 hasConcept C2780962732 @default.
• W4378348439 hasConcept C2781182431 @default.
• W4378348439 hasConcept C2781197716 @default.
• W4378348439 hasConcept C2992026798 @default.
• W4378348439 hasConcept C526805850 @default.
• W4378348439 hasConcept C55493867 @default.
• W4378348439 hasConcept C71924100 @default.
• W4378348439 hasConcept C86803240 @default.
• W4378348439 hasConceptScore W4378348439C121608353 @default.
• W4378348439 hasConceptScore W4378348439C126322002 @default.
• W4378348439 hasConceptScore W4378348439C143998085 @default.
• W4378348439 hasConceptScore W4378348439C146357865 @default.
• W4378348439 hasConceptScore W4378348439C151730666 @default.
• W4378348439 hasConceptScore W4378348439C185592680 @default.
• W4378348439 hasConceptScore W4378348439C2777148230 @default.
• W4378348439 hasConceptScore W4378348439C2780210213 @default.
• W4378348439 hasConceptScore W4378348439C2780521871 @default.
• W4378348439 hasConceptScore W4378348439C2780962732 @default.
• W4378348439 hasConceptScore W4378348439C2781182431 @default.
• W4378348439 hasConceptScore W4378348439C2781197716 @default.
• W4378348439 hasConceptScore W4378348439C2992026798 @default.
• W4378348439 hasConceptScore W4378348439C526805850 @default.
• W4378348439 hasConceptScore W4378348439C55493867 @default.
• W4378348439 hasConceptScore W4378348439C71924100 @default.
• W4378348439 hasConceptScore W4378348439C86803240 @default.
• W4378348439 hasFunder F4320324366 @default.
• W4378348439 hasLocation W43783484391 @default.
• W4378348439 hasLocation W43783484392 @default.

• next