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- W4378348517 abstract "Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobe that infects the colon. C. difficile is estimated to cause nearly half a million cases in the United States annually, with about 29,000 associated deaths. Unfortunately, the current antibiotic treatment is not ideal. While antibiotics can treat the infections, they also disrupt the gut microbiota that mediates colonization resistance against enteric pathogens, including C. difficile; disrupted gut microbiota provides a window of opportunity for recurrent infections. Therefore, therapeutics that restore the gut microbiota and suppress C. difficile are being evaluated for safety and efficacy. This review will start with mechanisms by which gut bacteria affect C. difficile pathogenesis, followed by a discussion on biotherapeutics for recurrent C. difficile infections." @default.
- W4378348517 created "2023-05-27" @default.
- W4378348517 creator A5006858153 @default.
- W4378348517 date "2023-05-09" @default.
- W4378348517 modified "2023-09-30" @default.
- W4378348517 title "Clostridioides difficile infection: microbe-microbe interactions and live biotherapeutics" @default.
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- W4378348517 doi "https://doi.org/10.3389/fmicb.2023.1182612" @default.
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