Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378349092> ?p ?o ?g. }
- W4378349092 endingPage "1417" @default.
- W4378349092 startingPage "1409" @default.
- W4378349092 abstract "Abstract Background Autoimmune mechanisms represent a novel category for causes of seizures and epilepsies in humans, and LGI1‐antibody associated limbic encephalitis occurs in cats. Hypothesis/Objectives To investigate the presence of neural antibodies in dogs with epilepsy or dyskinesia of unknown cause using human and murine assays modified for use in dogs. Animals Fifty‐eight dogs with epilepsy of unknown cause or suspected dyskinesia and 57 control dogs. Methods Serum and CSF samples were collected prospectively as part of the diagnostic work‐up. Clinical data including onset and seizure/episode type were retrieved from the medical records. Screening for neural antibodies was done with cell‐based assays transfected with human genes for typical autoimmune encephalitis antigens and tissue‐based immunofluorescence assays on mouse hippocampus slices in serum and CSF samples from affected dogs and controls. The commercial human und murine assays were modified with canine‐specific secondary antibody. Positive controls were from human samples. Results The commercial assays used in this study did not provide unequivocal evidence for presence of neural antibodies in dogs including one dog with histopathologically proven limbic encephalitis. Low titer IgLON5 antibodies were present in serum from one dog from the epilepsy/dyskinesia group and in one dog from the control group. Conclusion and Clinical Importance Specific neural antibodies were not detected using mouse and human target antigens in dogs with epilepsy and dyskinesia of unknown origin. These findings emphasize the need for canine‐specific assays and the importance of control groups." @default.
- W4378349092 created "2023-05-27" @default.
- W4378349092 creator A5002196833 @default.
- W4378349092 creator A5004775967 @default.
- W4378349092 creator A5008014164 @default.
- W4378349092 creator A5018730679 @default.
- W4378349092 creator A5022047680 @default.
- W4378349092 creator A5023390854 @default.
- W4378349092 creator A5029200804 @default.
- W4378349092 creator A5057551635 @default.
- W4378349092 creator A5079069766 @default.
- W4378349092 creator A5081134757 @default.
- W4378349092 creator A5082977080 @default.
- W4378349092 creator A5083168999 @default.
- W4378349092 creator A5089952505 @default.
- W4378349092 date "2023-05-26" @default.
- W4378349092 modified "2023-09-27" @default.
- W4378349092 title "Investigation of the presence of specific neural antibodies in dogs with epilepsy or dyskinesia using murine and human assays" @default.
- W4378349092 cites W1179790887 @default.
- W4378349092 cites W1860822802 @default.
- W4378349092 cites W1941551863 @default.
- W4378349092 cites W1981040757 @default.
- W4378349092 cites W2000528744 @default.
- W4378349092 cites W2005575607 @default.
- W4378349092 cites W2013085398 @default.
- W4378349092 cites W2038825681 @default.
- W4378349092 cites W2053141371 @default.
- W4378349092 cites W2058767113 @default.
- W4378349092 cites W2082362498 @default.
- W4378349092 cites W2110026843 @default.
- W4378349092 cites W2114935132 @default.
- W4378349092 cites W2143952309 @default.
- W4378349092 cites W2154193521 @default.
- W4378349092 cites W2163022996 @default.
- W4378349092 cites W2280783985 @default.
- W4378349092 cites W2321381259 @default.
- W4378349092 cites W2333632972 @default.
- W4378349092 cites W2566244391 @default.
- W4378349092 cites W2581437833 @default.
- W4378349092 cites W2586972945 @default.
- W4378349092 cites W2591153005 @default.
- W4378349092 cites W2592509339 @default.
- W4378349092 cites W2594525144 @default.
- W4378349092 cites W2595114075 @default.
- W4378349092 cites W2605154961 @default.
- W4378349092 cites W2617258020 @default.
- W4378349092 cites W2736610570 @default.
- W4378349092 cites W2789677349 @default.
- W4378349092 cites W2790441480 @default.
- W4378349092 cites W2790682074 @default.
- W4378349092 cites W2800863330 @default.
- W4378349092 cites W2884103526 @default.
- W4378349092 cites W2891971692 @default.
- W4378349092 cites W2921041321 @default.
- W4378349092 cites W2930698479 @default.
- W4378349092 cites W2950995625 @default.
- W4378349092 cites W2972350199 @default.
- W4378349092 cites W3014265312 @default.
- W4378349092 cites W3034212049 @default.
- W4378349092 cites W3042031325 @default.
- W4378349092 cites W3046568973 @default.
- W4378349092 cites W3123332580 @default.
- W4378349092 cites W3128479886 @default.
- W4378349092 cites W3136529993 @default.
- W4378349092 cites W4226240843 @default.
- W4378349092 cites W4283313681 @default.
- W4378349092 cites W4283399574 @default.
- W4378349092 cites W4378349092 @default.
- W4378349092 doi "https://doi.org/10.1111/jvim.16744" @default.
- W4378349092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37232512" @default.
- W4378349092 hasPublicationYear "2023" @default.
- W4378349092 type Work @default.
- W4378349092 citedByCount "2" @default.
- W4378349092 countsByYear W43783490922023 @default.
- W4378349092 crossrefType "journal-article" @default.
- W4378349092 hasAuthorship W4378349092A5002196833 @default.
- W4378349092 hasAuthorship W4378349092A5004775967 @default.
- W4378349092 hasAuthorship W4378349092A5008014164 @default.
- W4378349092 hasAuthorship W4378349092A5018730679 @default.
- W4378349092 hasAuthorship W4378349092A5022047680 @default.
- W4378349092 hasAuthorship W4378349092A5023390854 @default.
- W4378349092 hasAuthorship W4378349092A5029200804 @default.
- W4378349092 hasAuthorship W4378349092A5057551635 @default.
- W4378349092 hasAuthorship W4378349092A5079069766 @default.
- W4378349092 hasAuthorship W4378349092A5081134757 @default.
- W4378349092 hasAuthorship W4378349092A5082977080 @default.
- W4378349092 hasAuthorship W4378349092A5083168999 @default.
- W4378349092 hasAuthorship W4378349092A5089952505 @default.
- W4378349092 hasBestOaLocation W43783490921 @default.
- W4378349092 hasConcept C118552586 @default.
- W4378349092 hasConcept C142724271 @default.
- W4378349092 hasConcept C159654299 @default.
- W4378349092 hasConcept C163764329 @default.
- W4378349092 hasConcept C203014093 @default.
- W4378349092 hasConcept C2522874641 @default.
- W4378349092 hasConcept C2777699746 @default.
- W4378349092 hasConcept C2778186239 @default.
- W4378349092 hasConcept C2779134260 @default.