Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378374274> ?p ?o ?g. }
- W4378374274 endingPage "669" @default.
- W4378374274 startingPage "655" @default.
- W4378374274 abstract "Lung metastatic breast cancer is a leading cause of cancer-related death in women and difficult to treat due to non-specific drug delivery. Herein a sequential targeting dual-responsive magnetic nanoparticle was fabricated, where Fe3O4 nanoparticle was used as magnetic core, then sequentially coated with tetraethyl orthosilicate, bis[3-(triethoxy-silyl)propyl] tetrasulfide, and 3-(trimethoxysilyl) propylmethacrylate to afford -C = C- on the surface for further polymerisation with acrylic acid, acryloyl-6-ethylenediamine-6-deoxy-β-cyclodextrin using N, N-bisacryloylcy- stamine as cross-linker, obtaining pH/redox dual-responsive magnetic nanoparticle (MNPs-CD) to delivery doxorubicin (DOX) for suppressing lung metastatic breast cancer. Our results suggested DOX-loaded nanoparticle could target the lung metastases site by sequential targeting, in which they first be delivered to the lung and even the metastatic nodules through size-driven, electrical interaction, and magnetic field-guided mechanisms, then be effectively internalised into the cancer cells followed by intelligently triggering DOX release. MTT analysis demonstrated DOX-loaded nanoparticle exhibited high anti-tumour activity against 4T1 and A549 cells. 4T1 tumour-bearing mice were employed to confirm the higher specific accumulation in lung and improved anti-metastatic therapy efficiency of DOX by focussing an extracorporeal magnetic field on the biological target. Our findings suggested the as-proposed dual-responsive magnetic nanoparticle offered a prerequisite to inhibit lung metastasis of breast cancer tumours." @default.
- W4378374274 created "2023-05-27" @default.
- W4378374274 creator A5008768495 @default.
- W4378374274 creator A5018709776 @default.
- W4378374274 creator A5037692904 @default.
- W4378374274 creator A5038528725 @default.
- W4378374274 creator A5043523491 @default.
- W4378374274 creator A5044706990 @default.
- W4378374274 creator A5063071630 @default.
- W4378374274 creator A5078662652 @default.
- W4378374274 date "2023-06-07" @default.
- W4378374274 modified "2023-10-18" @default.
- W4378374274 title "Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer" @default.
- W4378374274 cites W1972609612 @default.
- W4378374274 cites W1973008689 @default.
- W4378374274 cites W1989495959 @default.
- W4378374274 cites W2003730644 @default.
- W4378374274 cites W2014260136 @default.
- W4378374274 cites W2014774262 @default.
- W4378374274 cites W2016525172 @default.
- W4378374274 cites W2021322124 @default.
- W4378374274 cites W2022204948 @default.
- W4378374274 cites W2033278321 @default.
- W4378374274 cites W2057910790 @default.
- W4378374274 cites W2069777400 @default.
- W4378374274 cites W2075592400 @default.
- W4378374274 cites W2077830231 @default.
- W4378374274 cites W2087041160 @default.
- W4378374274 cites W2088536552 @default.
- W4378374274 cites W2094154318 @default.
- W4378374274 cites W2096258216 @default.
- W4378374274 cites W2104086465 @default.
- W4378374274 cites W2130166533 @default.
- W4378374274 cites W2153962563 @default.
- W4378374274 cites W2160626915 @default.
- W4378374274 cites W2165031969 @default.
- W4378374274 cites W2215718728 @default.
- W4378374274 cites W2288119981 @default.
- W4378374274 cites W2314799819 @default.
- W4378374274 cites W2331882689 @default.
- W4378374274 cites W2335812415 @default.
- W4378374274 cites W2340985297 @default.
- W4378374274 cites W2406332780 @default.
- W4378374274 cites W2427645657 @default.
- W4378374274 cites W2469715701 @default.
- W4378374274 cites W2478711226 @default.
- W4378374274 cites W2594753103 @default.
- W4378374274 cites W2740408601 @default.
- W4378374274 cites W2784013833 @default.
- W4378374274 cites W2811347705 @default.
- W4378374274 cites W2896130004 @default.
- W4378374274 cites W2898658749 @default.
- W4378374274 cites W2906992534 @default.
- W4378374274 cites W2909844146 @default.
- W4378374274 cites W2914574872 @default.
- W4378374274 cites W2948997533 @default.
- W4378374274 cites W2951408205 @default.
- W4378374274 cites W2967901922 @default.
- W4378374274 cites W2991243793 @default.
- W4378374274 cites W2991922517 @default.
- W4378374274 cites W2994709081 @default.
- W4378374274 cites W2997731207 @default.
- W4378374274 cites W2998407485 @default.
- W4378374274 cites W3001493837 @default.
- W4378374274 cites W3004399392 @default.
- W4378374274 cites W3013813924 @default.
- W4378374274 cites W3016876865 @default.
- W4378374274 cites W3020990397 @default.
- W4378374274 cites W3044506787 @default.
- W4378374274 cites W3047280050 @default.
- W4378374274 cites W3085625554 @default.
- W4378374274 cites W3086567404 @default.
- W4378374274 cites W3087114884 @default.
- W4378374274 cites W3093127140 @default.
- W4378374274 cites W3097537426 @default.
- W4378374274 cites W3110635005 @default.
- W4378374274 cites W3119005666 @default.
- W4378374274 cites W3164963926 @default.
- W4378374274 cites W3167122021 @default.
- W4378374274 cites W4206118739 @default.
- W4378374274 cites W4211214747 @default.
- W4378374274 cites W4225371778 @default.
- W4378374274 cites W4283324594 @default.
- W4378374274 cites W4297896012 @default.
- W4378374274 cites W4312052188 @default.
- W4378374274 doi "https://doi.org/10.1080/1061186x.2023.2217699" @default.
- W4378374274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37235535" @default.
- W4378374274 hasPublicationYear "2023" @default.
- W4378374274 type Work @default.
- W4378374274 citedByCount "0" @default.
- W4378374274 crossrefType "journal-article" @default.
- W4378374274 hasAuthorship W4378374274A5008768495 @default.
- W4378374274 hasAuthorship W4378374274A5018709776 @default.
- W4378374274 hasAuthorship W4378374274A5037692904 @default.
- W4378374274 hasAuthorship W4378374274A5038528725 @default.
- W4378374274 hasAuthorship W4378374274A5043523491 @default.
- W4378374274 hasAuthorship W4378374274A5044706990 @default.
- W4378374274 hasAuthorship W4378374274A5063071630 @default.