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- W4378379858 endingPage "125009" @default.
- W4378379858 startingPage "125009" @default.
- W4378379858 abstract "Three isomeric nitrosylruthenium complexes [RuNO(Qn)(PZA)Cl] (P1, P2, and P3) with bioactive small molecules 8-hydroxyquinoline (Qn) and pyrazinamide (PZA) as co-ligands were synthesized, and their crystal structures were determined using X-ray diffraction technique. The cellular toxicity of the isomeric complexes was compared to understand the effects of the geometries on the biological activity of the complexes. Both the complexes and the human serum albumin (HSA) complex adducts affected the extent of proliferation of HeLa cells (IC50: 0.77–1.45 μM). P2 showed prominent activity-induced cell apoptosis and arrested cell cycles at the G1 phase. The binding constants (Kb) of the complex with calf thymus DNA (CT-DNA) and HSA were quantitatively evaluated using fluorescence spectroscopy in the range of 0.17–1.56 × 104 M−1 and 0.88–3.21 × 105 M−1, respectively. The average binding site (n) number was close to 1. Moreover, the structure of HSA and the P2 complex adduct solved at the resolution of 2.48 Å revealed that one PZA-coordinated nitrosylruthenium complex bound at the subdomain I of HSA via a noncoordinative bond. HSA could serve as a potential nano-delivery system. This study provides a framework for the rational design of metal-based drugs." @default.
- W4378379858 created "2023-05-27" @default.
- W4378379858 creator A5022432524 @default.
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- W4378379858 creator A5049608012 @default.
- W4378379858 creator A5055820540 @default.
- W4378379858 creator A5082013054 @default.
- W4378379858 date "2023-07-01" @default.
- W4378379858 modified "2023-09-25" @default.
- W4378379858 title "Synthesis, cytotoxicity, and biomacromolecule binding: Three isomers of nitrosylruthenium complexes with bidentate bioactive molecules as co-ligands" @default.
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