Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378437872> ?p ?o ?g. }
- W4378437872 endingPage "112525" @default.
- W4378437872 startingPage "112525" @default.
- W4378437872 abstract "Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification." @default.
- W4378437872 created "2023-05-27" @default.
- W4378437872 creator A5003349585 @default.
- W4378437872 creator A5003529606 @default.
- W4378437872 creator A5005631780 @default.
- W4378437872 creator A5007372940 @default.
- W4378437872 creator A5009041563 @default.
- W4378437872 creator A5009047365 @default.
- W4378437872 creator A5012089845 @default.
- W4378437872 creator A5013457292 @default.
- W4378437872 creator A5016225831 @default.
- W4378437872 creator A5019504046 @default.
- W4378437872 creator A5020245965 @default.
- W4378437872 creator A5020418899 @default.
- W4378437872 creator A5024463990 @default.
- W4378437872 creator A5027136704 @default.
- W4378437872 creator A5029255809 @default.
- W4378437872 creator A5029679296 @default.
- W4378437872 creator A5029722300 @default.
- W4378437872 creator A5030285007 @default.
- W4378437872 creator A5031735707 @default.
- W4378437872 creator A5032022666 @default.
- W4378437872 creator A5035426150 @default.
- W4378437872 creator A5037499701 @default.
- W4378437872 creator A5040040896 @default.
- W4378437872 creator A5040118446 @default.
- W4378437872 creator A5040218234 @default.
- W4378437872 creator A5044242375 @default.
- W4378437872 creator A5051149616 @default.
- W4378437872 creator A5051853913 @default.
- W4378437872 creator A5061273288 @default.
- W4378437872 creator A5063080199 @default.
- W4378437872 creator A5063254041 @default.
- W4378437872 creator A5065110382 @default.
- W4378437872 creator A5066955374 @default.
- W4378437872 creator A5070796928 @default.
- W4378437872 creator A5071574505 @default.
- W4378437872 creator A5073445890 @default.
- W4378437872 creator A5075987867 @default.
- W4378437872 creator A5076048446 @default.
- W4378437872 creator A5076251093 @default.
- W4378437872 creator A5079216195 @default.
- W4378437872 creator A5079295101 @default.
- W4378437872 creator A5080670860 @default.
- W4378437872 creator A5082416154 @default.
- W4378437872 creator A5083128670 @default.
- W4378437872 creator A5084474144 @default.
- W4378437872 creator A5085408217 @default.
- W4378437872 creator A5087983005 @default.
- W4378437872 creator A5088399987 @default.
- W4378437872 date "2023-06-01" @default.
- W4378437872 modified "2023-10-12" @default.
- W4378437872 title "Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease" @default.
- W4378437872 cites W1723532226 @default.
- W4378437872 cites W2019115048 @default.
- W4378437872 cites W2019552331 @default.
- W4378437872 cites W2035618305 @default.
- W4378437872 cites W2036897871 @default.
- W4378437872 cites W2043450272 @default.
- W4378437872 cites W2076532880 @default.
- W4378437872 cites W2082817623 @default.
- W4378437872 cites W2104168490 @default.
- W4378437872 cites W2109830821 @default.
- W4378437872 cites W2116514576 @default.
- W4378437872 cites W2125605790 @default.
- W4378437872 cites W2132270657 @default.
- W4378437872 cites W2145825942 @default.
- W4378437872 cites W2146512944 @default.
- W4378437872 cites W2158507525 @default.
- W4378437872 cites W2160585439 @default.
- W4378437872 cites W2161713331 @default.
- W4378437872 cites W2169456326 @default.
- W4378437872 cites W2178817582 @default.
- W4378437872 cites W2179438025 @default.
- W4378437872 cites W2190545194 @default.
- W4378437872 cites W2197124664 @default.
- W4378437872 cites W2230716962 @default.
- W4378437872 cites W2317865868 @default.
- W4378437872 cites W2323326409 @default.
- W4378437872 cites W2439973029 @default.
- W4378437872 cites W2517949416 @default.
- W4378437872 cites W2525566675 @default.
- W4378437872 cites W2531799775 @default.
- W4378437872 cites W2550451436 @default.
- W4378437872 cites W2609105246 @default.
- W4378437872 cites W2616922646 @default.
- W4378437872 cites W2624144799 @default.
- W4378437872 cites W2743344672 @default.
- W4378437872 cites W2761458735 @default.
- W4378437872 cites W2787894829 @default.
- W4378437872 cites W2793472682 @default.
- W4378437872 cites W2794480084 @default.
- W4378437872 cites W2800392236 @default.
- W4378437872 cites W2888894833 @default.
- W4378437872 cites W2905381998 @default.
- W4378437872 cites W2915717782 @default.
- W4378437872 cites W2916407275 @default.
- W4378437872 cites W2940108326 @default.