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- W4378468575 abstract "The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. In this paper, we investigate how phenotypic switching at the cancer cell level impacts on behaviour at the tissue level, specifically on the emergence of isolated foci of the invading solid tumour mass leading to a multifocal tumour. To this end, we propose a new mathematical model of cancer invasion that includes the influence of cancer cell phenotype on the rate of invasion and metastasis. The implications of model are explored through numerical simulations revealing that the plasticity of tumour cell phenotypes appears to be crucial for disease progression and local invasive spread. The computational simulations show the progression of the invasive spread of a primary cancer reminiscent of in vivo multifocal breast carcinomas, where multiple, synchronous, ipsilateral neoplastic foci are frequently observed and are associated with a poorer patient prognosis." @default.
- W4378468575 created "2023-05-27" @default.
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- W4378468575 date "2023-05-22" @default.
- W4378468575 modified "2023-09-25" @default.
- W4378468575 title "Mathematical modelling of cancer invasion: Phenotypic transitioning provides insight into multifocal foci formation" @default.
- W4378468575 doi "https://doi.org/10.48550/arxiv.2305.14388" @default.
- W4378468575 hasPublicationYear "2023" @default.
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